Term
Duloxetine HCl
Drug Interactions |
|
Definition
1. MAO-Is
2. Inhibitors of CYP1A2 - Fluvoxamine, Quniolone
3. Inhibitors of CYP2D6 - Paroxetine, Fluoxetine, Quinidine
4. Drugs metabolized by 2D6 will be increased - TCAs, Phenothiazines, Propafenone, & Flecainide |
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Term
Venlafaxine HCl
Drug Interactions |
|
Definition
1. MAO-Is
2. Antihistamines
3. ASA or NSAID increase risk of upper GI bleeding |
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Term
Sertraline HCl
Drug Interactions |
|
Definition
1. MAO-Is
2. Increase Pimozide levels
3. Displaced by or displace other - Warfarin, Digitoxin
4. Decrease clearance of Diazepam & Tolbutamide
5. Variable effects may occur w/ CYP3A3/4
6. ASA & NSAID increase risk of upper GI bleeding |
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Term
Trazodone HCl
Drug Interactions |
|
Definition
1. OH and CNS depressants increase drowsiness
2. Increase effects of Phenytoin
3. Grapefruit juice may increase plasma levels
4. CYP3A4 inhibitors (ketoconazole, ritonavir, indinavir) may decrease metabolism of trazodone |
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Term
Citalopram HBr
Drug Interactions |
|
Definition
1. MAO-Is
2. Cimetidine may increase plasma levels
3. ASA and NSAID increase risk of upper GI bleeding |
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Term
Amitriptyline HCl
Drug Interactions |
|
Definition
1. Increase action of dicumarol
2. Decrease effectiveness of clonidine & guanethidine
3. MAO-Is
4. OH and CNS depressants increase drowsiness
5. Cimetidine increases plasma level |
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Term
Bupropion HCl
Drug Interactions |
|
Definition
1. Toxicity is increased by MAO-I & L-Dopa
2. Caution in hepatic drug metabolizing systems
3. OH lowers the seizure threshold |
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Term
Escitalopram Oxalate
Drug Interactions |
|
Definition
1. MAO-Is
2. Cimetidine may increase plasma levels
3. ASA and NSAID increase risk of upper GI bleeding |
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Term
Fluoxetine HCl
Drug Interactions |
|
Definition
1. MAO-Is
2. Increase thioridazine
3. Increase plasma levels of TCAs, Benzodiazepines, Phenytoin,, Carbamazepine, and drugs metabolized by P450IID6
4. ADE occur w/ Tryptophan or Sumatriptan
5. ASA or NSAID may increase risk of upper GI bleeding |
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Term
Donepezil HCl
Drug Interactions |
|
Definition
1. Phenytoin, carbamazepine, [henobarbital, rifampin, or dexamethasone increase the metabolism
2. Ketoconazole or quinidine decreases metabolism |
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Term
Quetiapine Fumerate
Drug Interactions |
|
Definition
1. CNS depressants
2. Oral clearance is increased by phenytoin & thioridazine |
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Term
Aripiprazole
Drug Interactions |
|
Definition
1. CYP3A4 inducers (carbamazepine) may decrease plasma levels
2. CYP3A4 inhibitors (quinidine, fluoxetine, and paroxetine) may increase plasma |
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Term
Risperidone
Drug Interactions |
|
Definition
1. Decrease the effects of levodopa
2. Carbamazepine increase the clearance
3. Fluoxetine may double or triple the plasma [ ]s
4. Clozapine may decrease the clearance |
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|
Term
Pregabalin
Drug Interactions |
|
Definition
1. CNS depressants
2. Peripheral edema may occur when given with thiazolidinedione antidiabetic agents |
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Term
Lamotrigine
Drug Interactions |
|
Definition
1. Phenytoin, carbamazepine, phenobarbital, & rifampin increase the metabolism
2. Valproic acid increases plasma [] while lamotrigine decreases []of valproic acid
3. It is a potent inhibitor of dihydrofolate reductase
4. OC - decrease the progestin component while decrease the serum [] of lamotrigine |
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Term
Divalproex Na
Drug Interactions |
|
Definition
1. ASA, carbamazepine, & dicumarol - alter serum levels thru ptn binding
2. Impair the renal clearance of phenobarbital
3. alter the levels on phenytoin
4. use w/ clonazepam may cause absence seizures |
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Term
Gababpentin
Drug Interactions |
|
Definition
| Antacids decrease bioavailability |
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|
Term
Clonazepam
Drug Interactions |
|
Definition
|
|
Term
Topiramate
Drug Interactions |
|
Definition
1. OH & CNS depressants
2. increase metabolism of estrogens
3. increase metformin blood levels
4. It is a weak carbnic anhydrase inhibitor
5. Phyenytoin & carbamazepine may decrease the drug
6. HCTZ may raise the blood level
7. Use w/ valproic acid may cause hyperammonemia |
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Term
Diazepam
Drug Interactions |
|
Definition
1. CNS depressants
2. Cimetidine may delay clearance
3. Grapefruit juice may increase plasma |
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|
Term
Alprazolam
Drug Interactions |
|
Definition
|
|
Term
Lorazepam
Drug Interactions |
|
Definition
1. CNS depressants
2. Probenecid or valproate decrease the excretion |
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|
Term
Zolpidem Tartrate
Drug Interactions |
|
Definition
|
|
Term
Tramadol HCl
Drug Interactions |
|
Definition
1. MAOIs & TCAs
2. Risk of seizures - 5HT reuptake inhibitors, TCAs, & opiods
3. Quinidine increased []s of tramadol & reduced []s of M1
4. Carbamazepine increases metabolism |
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|
Term
Propoxyphene Napsylate with Acetaminophen
Drug Interactions |
|
Definition
1. OH & CNS depressants
2. increase Carbamazepine
3. Hydantoin or sulfinpyrazone - hepatotoxicity |
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|
Term
Oxycodone with Acetaminophen
Drug Interactions |
|
Definition
1. OH & CNS depressants
2. Hydantoin or sulfinpyrazone - hepatotoxicity |
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Term
Oxycodone HCl (controlled-release)
Drug Interactions |
|
Definition
| Enhance the actions of phenothiazines, general anesthetics, sedatives, hypnotics, OH, skeletal muscle relaxants, & agonist/antagonist analgesics |
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Term
Hydrocodone Bitartrate with Acetaminophen
Drug Interactions |
|
Definition
1. OH & CNS depressants
2. MAOI or TCAs
3. Anticholinergics may produce paralytic ileus
4. Hydantoin or sulfinpyrazone - |
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|
Term
Ibuprofen
Drug Interactions |
|
Definition
1. ASA increases plasma clearance
2. Probenecid decreases plasma clearance
3. Increase toxicity of Li
4. Decrease the effects of B-adrenergic blockers
5. decrease the actions of LOOPs |
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|
Term
Meloxicam
Drug Interactions |
|
Definition
1. Increase Li
2. Decrease effects of ACEI
3. Cholestyramine increases the clearance
4. increase NSAID & ASA
5. Use in caution w/ Warfarin |
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|
Term
Naproxen
Drug Interactions |
|
Definition
1. Increase the effects of oral anticoagulants, Li,& methotrexate
2. Do not use w/ other NSAIDs |
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|
Term
Cyclobenzaprine
Drug Interactions |
|
Definition
1. OH & CNS depressants
2. Decrease the effects of guanethidine |
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|
Term
Carisoprodol
Drug Interactions |
|
Definition
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|
Term
Rosuvastatin Ca
Drug Interactions |
|
Definition
1. Cyclosporine increases plasma
2. Warfarin increases INR
3. Gemfibrozil increases plasma
4. Antacids decreases plasma |
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|
Term
Atorvastatin Ca
Drug Interactions |
|
Definition
1. increase digoxin
2. Gemfibrozil, grapfruit, nicotinic acid, itraconazole, erthyromycin, clarithromycin, azole antifungals, protease inhibitor combos, and cyclosporine increase plasma levels |
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|
Term
Lovastatin
Drug Interactions |
|
Definition
1. Gemfibrozil may cause severe myopathy or rhabdo
2. Grapefruit juice increases plasma (avoid) |
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|
Term
Simvastatin
Drug Interactions |
|
Definition
1. Increase warfarin or digoxin
2. Gemfribrozil, nicotinic acid, danazol, amiodarone, verapamil, immunosupppressive agents and potent CYP3A4 inhibitors (itra, keto, erythro, clarithro, telithro, HIV protease inhibitors, nefazodone, & grapefruit juice) may cause myopathy or rhabdo |
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Term
Glipizide
Drug Interactions |
|
Definition
1. Dicumarol, chloramphenicol, OH, MAOI, phenylbutazones, salicylates, sulfinpyrazone, & sulfonamides may increase the effects
2. Diazoxide, rifampin, & thiazide diuretics may decrease effects |
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Term
Glyburide
Drug Interactions |
|
Definition
1. Dicumarol, chloramphenicol, OH, MAOI, phenylbutazones, salicylates, sulfinpyrazone, & sulfonamides may increase the effects
2. Diazoxide, rifampin, & thiazide diuretics may decrease effects |
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|
Term
Pioglitazone HCl
Drug Interactions |
|
Definition
1. Keto, itra, & gemfibrozil may inhibit metaboism
2. Rifampin decreases plasma |
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|
Term
Insulin Glargine, rDNA origin
Drug Interactions |
|
Definition
1. Corticosteroids, diltiazem, dobutamine, E, OC, thiazide, thyroid, & tobacco smoke decrease hypoglycemic effect
2. OH, anabolic steroids, nonselective BB, clofibrate, fenfluamine, guanethidine, MAOIs, phenylbutazone, salicylates, sulfinypyrazone, & TET increase the hypoglycemic |
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|
Term
Metformin HCl
Drug Interactions |
|
Definition
| Furosemide, cimetidine, & nefedipine may increase plasma level |
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|
Term
Fenofibrate
Drug interactions |
|
Definition
1. increase actions of warfarin
2. No HMG-CoA reductase inhibitors
3. Cholestryamine decrease the absorption |
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Term
Lisinopril w/ HCTZ
Drug Interactions |
|
Definition
1. Indomethacin decreases effect
2. Allopurinol increases hypersensitivity
3. K supplements cause hyperkalemia
4. Digitalis induced arrhythmias
5. Diazoxide cause hyperglycemia
6. Increase Li |
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|
Term
Diltiazem HCl
Drug Interactions |
|
Definition
1. enhance actions of cyclosporine
2. Cimetidine may increase plasma
3. increase levels of carbamazepine |
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|
Term
Clonidine HCl
Drug Interactions |
|
Definition
1. Decreases BP w/ TCA
2. Increases BP w/ BB |
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|
Term
Atenolol
Drug Interactions |
|
Definition
1. Decrease effects of Clonidine
2. NSAIDs may decrease the effects
3. Verapamil may increase toxic effects
4. Increase toxic effects of lidocaine
5. increase postural hypotension w/ prazosin
6. AMP decrease effects |
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Term
Metoprolol succinate
Drug Interactions |
|
Definition
1. Decrease theophyllines
2. Barbiturates & rifampin decrease
3. Hydralazine, propafenone, or thioamines increase
4. NSAIDs decrease
5. Toxic effects w/ verapamil
6. increases toxic effects of lidocaine
7. Prazosin increase postural hypotension |
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Term
Metoprolol Tartrate
Drug Interactions |
|
Definition
1. Decrease theophyllines
2. Barbiturates & rifampin decrease
3. Hydralazine, propafenone, or thioamines increase
4. NSAIDs decrease
5. Toxic effects w/ verapamil
6. increases toxic effects of lidocaine
7. Prazosin increase postural hypotension
8. Digitalis - additive bradycardia |
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Term
Carvediolol
Drug Interactions |
|
Definition
1. rifampin decreases
2. Cimetidine increases AUC but not Cmax
3. Quinidine, fluoxetine, paroxetine, & propafenone increase
4. reserpine, clonidine, digoxin, or MAO produce hypotension or bradycardia
5. Diltiazem or verapamil cause conduction disturbances
6. increase digoxin
7. inhibitors CYP2C9 (amiodarone or fluconazole may exacerbate bradycardia |
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|
Term
Amlodipine Besylate
Drug Interactions |
|
Definition
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|
Term
Lisinopril
Drug interactions |
|
Definition
1. Indomethacin decreases effect
2. Capsaicin increase the coughing
3. Allopurinol - hypersenstivity
4. decreases Li elimination
5. K - hyperkalemia
6. Potentate - oral antidiabetics and/or insulin |
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|
Term
|
Definition
1. decrease sulfonylurea hypoglycemia
2. digitalis induced arrhythmias
3. diazoxide - hyperglycemia
4. increase Li |
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|
Term
Spironolactone
Drug interactions |
|
Definition
1. Hyperkalemia w/ captopril & K sparing
2. variable effects w/ digitalis glycosides |
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|
Term
Furosemide
Drug interactions |
|
Definition
1. Auditory toxicity - cisplatin or AGs
2. Phenytoin & NSAIDs reduced effects
3. Hypokalemia - digitalis induced arrhythmias
4. Hypokalemic - K-depleting drugs |
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|
Term
Tiotropium Br
Drug interactions |
|
Definition
|
|
Term
Levalbuterol HCl
Drug interactions |
|
Definition
1. sympathomimetics, TCAS, & MAOIs increase the toxicity
2. Hypokalemia - non-K sparing diuretics
3. Decrease digoxin levels |
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|
Term
Ipratropium Br w/ Albuterol Sulfate
Drug interactions |
|
Definition
1. sympathomimetics, TCAS, & MAOIs increase the toxicity
2. Hypokalemia - non-K sparing diuretics |
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|
Term
Fluticasone Propionate w/ Salmeterol Xinafoate
Drug interactions |
|
Definition
1. Additives effect w/ systemic corticosteroids
2. sympathomimetics, TCAS, & MAOIs increase the toxicity
3. BBs decrease the salmeterol effect |
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|
Term
Albuterol Sulfate
Drug interactions |
|
Definition
1. sympathomimetics, TCAS, & MAOIs increase the toxicity
2. Hypokalemia - non-K sparing diuretics
3. Decrease digoxin levels |
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|
Term
Montelukast Na
Drug interactions |
|
Definition
1. Phenobarbital increase metabolism
2. Decrease metabolism of Paclitxel, rosiglitazone, & repaglinide |
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|
Term
Fluticasone Propionate
Drug interactions |
|
Definition
| Systemic corticosteroids - synergistic effects |
|
|
Term
Fexofenadine HCl
Drug interactions |
|
Definition
|
|
Term
Sulfamethoxazole w/ Trimethoprim
Drug interactions |
|
Definition
1. Decrease the effects of cyclosporine
2. increase procainamide & hydantoins
3. increase oral anticoagulatns & sulfonylureas |
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|
Term
Amoxicillin Trihydrate
Drug interactions |
|
Definition
1. OC
2. Bacteriostatic antibiotics
3. Renal excretion will be decreased w/ probenecid |
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|
Term
Azithromycin Dihydrate
Drug interactions |
|
Definition
1. Antacids slow absorption
2. Food decreases absorption
3. Nelfinavir increases [] |
|
|
Term
Pantoprazole Na
Drug interactions |
|
Definition
| Raises the pH of the stomach, drugs which require a low pH for absorption (keto, amp esters, Fe salts) |
|
|
Term
Ranitidine HCl
Drug interactions |
|
Definition
1. Decrease warfarin & lidocaine clearance
2. increase absorption of triazolam
3. decrease metabolism of nifedipine & TCAs |
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|
Term
Omeprazole
Drug interactions |
|
Definition
1. Increases plasma of diazepam, phenytoin, & warfarin
2. May interact w/ CYP450 (cyclosporine, disulfiram, benzo)
3. Gastric pH: keto, digoxin, cyanocobalamin, amp esters, & Fe salts
4. Voriconazole increases plasma |
|
|
Term
Esomeprazole Mg
Drug interactions |
|
Definition
1. increases plasma of diazepam
2. Gastric pH: keto, digoxin, cyanocobalamin, amp esters, & Fe salts
3. decrease the plasma level of atazanavir
4. Voriconazole increases plasma |
|
|
Term
|
Definition
| K-sparing diuretics, aldosterone antagonists, ACEI, K-containing meds, or salt substitutes |
|
|
Term
Metoclopramide HCl
Drug interactions |
|
Definition
1. OH & CNS depressants
2. increase cyclosporine
3. decrease digoxin
4. increase succinylcholine |
|
|
Term
|
Definition
1. inhibits the effects of probenecid & sulfinpyrazone
2. anticoagulants - additive effects
2. anti-inflammatory drugs - decreases effectiveness & increase ulcerogenic effects of both |
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|
Term
Clopidogrel Bisulfate
Drug interactions |
|
Definition
1. Predispose occult blood w/ NSAIDs
2. interfere w/ metabolism of phenytoin, tamoxifen, tobutamide, warfarin, torsemide, fluvastatin, & NSAIDs |
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|
Term
Warfarin Na
Drug interactions |
|
Definition
|
|
Term
Prednisone
Drug interactions |
|
Definition
1. antagonize the effects of anticholinesterases
2. Barbiturates, rifampin, & hydantoins increase metabolism
3. Estrogens decrease metabolism
4. Keto may increase effects
5. Decrease salicylate effects |
|
|
Term
Tamsulosin
Drug interactions |
|
Definition
1. Additive effects w/ other aa-blocking agents
2. Cimetidine dcreases clearance & raises plasma levels |
|
|
Term
Tolterodine Tartrate
Drug interactions |
|
Definition
| Inhibitors of CYP3A4 (keto, itra, micon, erythro, clarithro, cyclosporine, & vinblastine) may increase plasma |
|
|
Term
Alendronate Na
Drug interactions |
|
Definition
1. Ca & antacids may decrease absorption if taken w/in 30 min
2. ASA increase GI effects |
|
|
Term
Levothyroxine Na
Drug interactions |
|
Definition
1. increase effects of oral anticoagulant
2. cholestyramine may decrease the absorption
3. decrease effects of digitalis glycosides |
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