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Drug Reactions
First Aid 2012 pp271-272
47
Medical
Graduate
01/16/2013

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Term
coronary vasospasm
Definition
cocaine, sumariptan
Term
cutaneous flushing
Definition
vancomycin, adenosine, niacin, calcium channel blockers (VANC)
Term
dilated cardiomyopathy
Definition
doxorubicin (Adriamycin), daunorubicin
Term
torsades de pointes
Definition
Class III (sotalol), class IA (quinidine) antiarrhythmics
Term
agranulocytosis
Definition
clozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone (Agranulocytosis Could Certainly Cause Pretty Major Damage)
Term
aplastic anemia
Definition
chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole, carbamazepine
Term
direct Coombs-positive hemolytic anemia
Definition
methyldopa
Term
grey baby syndrome
Definition
chloramphenicol
Term
hemolysis in G6PD-deficient patients
Definition
isoniazid, sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin (hemolysis IS PAIN)
Term
megaloblastic anemia
Definition
phenytoin, methotrexate, sulfa drugs (having a blast with PMS)
Term
thrombotic complications
Definition
OCPs
Term
cough
Definition
ACE inhibitors
Term
pulmonary fibrosis
Definition
bleomycin, amiodarone, busulfan (it's hard to BLAB when you have pulmonary fibrosis)
Term
acute cholestatic hepatitis
Definition
macrolides
Term
focal to massive hepatic necrosis
Definition
halothane, acetaminophen, valproic acid, Amanita phalloides (liver HAVAc)
Term
valproic acid
Definition
focal to massive hepatic necrosis
Term
Amanita phalloides
Definition
focal to massive hepatic necrosis
Term
hepatitis
Definition
isoniazid
Term
pseudomembranous colitis
Definition
clindamycin, ampicillin
Term
adrenocortical insufficiency
Definition
glucocorticoid withdrawal (HPA suppression)
Term
gynceomastia
Definition
spironolactone, digoxin, cimetidine, chronic alcohol use, estrogens, ketoconazole (some drugs create awesome knockers)
Term
hot flashes
Definition
tamoxifen, clomiphene
Term
hypothyroidism
Definition
lithium, amiodarone, sulfonamides
Term
hyperglycemia
Definition
niacin, tacrolimus, protease inhibitors
Term
fat redistribution
Definition
flucocorticoids, protease inhibitors
Term
gingival hyperplasia
Definition
phenytoin, verapamil

** high PDGF!! **
Term
gout
Definition
furosemide, thiazides, niacin, cyclosporine, pyrazinamide
Term
myopathies
Definition
fibrates, niacin, colchicine, hydroxychlorquine, interferon alpha, penicillamine, statins, glucocorticoids (Fish N CHIPS Give you myopathies)
Term
osteoporosis
Definition
heparin, corticosteroids
Term
photosensitivity
Definition
sulfonamides, amiodarone, tetracycline (SAT for a photo)
Term
rash (Stevens-Johnson syndrome)
Definition
penicillin, ethosuximide, carbamazepine, sulfa drugs, lamotrigine, allopurinol, phenytoin, phenobarbital (bad rash after a PEC SLAPP)
Term
SLE-like syndrome
Definition
hydralazine, isoniazid, procainamide, phenytoin (it's not HIPP to have lupus)
** slow acetylator!! **
Term
tendonitis/tendon rupture
Definition
fluoroquinolones
Term
cartilage damage
Definition
fluoroquinolones
Term
diabetes insipidus
Definition
lithium, demeclocycline
Term
Fanconi's syndrome
Definition
expired tetracycline
Term
interstitial nephritis
Definition
methicillin, NSAIDs, furosemide, sulfonamides, rifampin
Term
hemorrhagic cystitis
Definition
cyclophosphamide, ifosfamide (prevent by co-administering with mesna)
Term
SIADH
Definition
carbamazepine, cyclophosphamide
Term
cinchonism
Definition
quinidine, quinine
Term
Parkinson-like syndrome
Definition
antipsychotics, reserpine, metoclopramide
Term
seizures
Definition
bupropion, imipenem/cilastatin, isoniazid
Term
tardive dyskinesia
Definition
antipsychotics
Term
antimuscarinic
Definition
atropine, TCAs, H1 blockers, neuroleptics
Term
disulfiram-like reaction
Definition
Make Certain Sailors Puke!!
Metronidazole
certain Cephalosporins
1st-gen Sulfonylureas
Procarbazine
Term
nephrotoxicity/ototoxicity
Definition
aminoglycosides, vancomycin, loop diuretics (i.e. furosemide), cisplatin
Term
cholinergic
Definition
digoxin
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