Term
|
Definition
conj equine
conj synthetic
estradiol
ethinyl estradiol |
|
|
Term
|
Definition
|
|
Term
|
Definition
menopausal hormone replacement
prevention of post-menopausal osteoporosis |
|
|
Term
|
Definition
endometrial hyperplasia -> CA's
CV events
promote growth of CA w/ estrogen receptors |
|
|
Term
|
Definition
medroxyprogesterone acetate
norethindrone acetate
megesterol acetate
Microionized form |
|
|
Term
|
Definition
medroxyprogesterone acetate
progesterone |
|
|
Term
|
Definition
|
|
Term
|
Definition
norethindrone (+ estradiol)
lebonorgestrel (+ estradiol) |
|
|
Term
|
Definition
post-menopausal hormone tx
dysfunctinoal uterine bleeding
amenorrhea |
|
|
Term
| how does progestin help dysfunctional uterine bleeding |
|
Definition
| balancing influence of estrogen on the endometrium |
|
|
Term
|
Definition
| conjugated estrogens/medroxyprogesterone acetate |
|
|
Term
Selective Estrogen Receptor Modulators
(SERMS) |
|
Definition
Tamoxifen
Raloxifene
Toremifene
Fulvestsrant |
|
|
Term
| which SERM shows no increased risk of endometrial CA |
|
Definition
|
|
Term
| which SERM shows fewer cases of blood clotting |
|
Definition
|
|
Term
| which SERM shows NO risk of endometrial CA |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| activate estrogen receptors in SOME tissues and BLOCK them in others |
|
|
Term
|
Definition
benefits estrogen w/o risks
inhibit breast tissue growth
incr bone mineral density
decr LDL and incr HDL |
|
|
Term
|
Definition
hot flashes
fluid retention
vag discharge
N/V
menstrual irregularities
endometrial CA |
|
|
Term
| SERMS ___ LDL and ___ HDL |
|
Definition
| DECREASE LDL, INCREASE HDL |
|
|
Term
| SERMS are used in the tx and prevention of |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| what 2 estrogens are used in OCP's |
|
Definition
ethinyl estradiol
mestranol (converts to ethinyl estradiol in body) |
|
|
Term
| what is the most common progestin used in OCP's |
|
Definition
|
|
Term
| OCP's w/ constant doses throughout cycle |
|
Definition
|
|
Term
| OCP where estrogen is constant and progestin incr over 2nd half of cylce |
|
Definition
|
|
Term
| OCP where doses are divided into 3 phases where progestin levels change. also estrogen may vary too |
|
Definition
|
|
Term
|
Definition
inhibit ovulation
thicken cervical mucous
modify endometrium (less favorable implant) |
|
|
Term
| non-contraceptive tx uses of OCP's |
|
Definition
decr risk endometrial, ovarian CA/ cysts
PID, PMS, TSS, anemia, acne
decr cramps
lighter shorter period (more predictable) |
|
|
Term
|
Definition
thromboembolic d/o
HTN
CA (protect some, incr risk others)
abn. uterine bleeding
benign hepatic adenoma
mult births
glucose intolerance
gallballder dz
melanoderma
acne, hirsuitism, hair loss |
|
|
Term
|
Definition
N
breast tenderness
edema |
|
|
Term
|
Definition
increased appetite
fatigue
depression |
|
|
Term
|
Definition
|
|
Term
| what drugs reduce OCP effectiveness |
|
Definition
rifampin
carbamazepine
phenobarb
phenytoin
st. johns wort
(P450 inducers)
antibiotics that decr enterohep cycling |
|
|
Term
|
Definition
warfarin
hypoglycemic agents
|
|
|
Term
|
Definition
theophylline
imipramine
(impairs hepatic met) |
|
|
Term
|
Definition
EE and drospirenone
*reduce fluid retention |
|
|
Term
| what is the major concern of yasmin |
|
Definition
|
|
Term
|
Definition
EE and norelgestromin
levels plateau day 2
> E than OCPs |
|
|
Term
|
Definition
HA
skin irritation
N
cramping |
|
|
Term
|
Definition
|
|
Term
|
Definition
vaginitis
HA
wt. gain
N
thrombosis
HTN
embolism |
|
|
Term
|
Definition
alter cervical excretions
endometrium less favorable for implant |
|
|
Term
|
Definition
irregularity/spotting
amenorrhea
inconsistent cycles |
|
|
Term
| do progestin only meds cause thromboembolic d/o? |
|
Definition
|
|
Term
| what to do w/ missed dose of progestin only |
|
Definition
1 x: take ASAP
2 x: asap, discard other
3 x: d/x until menstruations -> r/o prego |
|
|
Term
| long-acting contraceptives |
|
Definition
implant
depo medroxyprogesterone acetate |
|
|
Term
|
Definition
inhibit ovulations by preventing mid-cycle lutenizing homrone peak
changes in cervical mucous |
|
|
Term
| most effective form contraceptive |
|
Definition
|
|
Term
|
Definition
w/i 8 hrs
peaks 4 days-> steady |
|
|
Term
|
Definition
menstrual irregularities
prolonged bleeding
spotting
breast d/c
cervicitis/vaginitis |
|
|
Term
|
Definition
|
|
Term
| what dose for estrogen to start out |
|
Definition
|
|
