Term
| what causes exocytosis of NE or Epi? |
|
Definition
|
|
Term
| what does Ca cause contraciotn of-3 |
|
Definition
| skeletal, cardiac, smooth muscle |
|
|
Term
at rest what is the level of intracellular Ca?
what about extracellular? |
|
Definition
low- <.1 micrometer
higherr- 1 mM |
|
|
Term
| what are the two mechanisms of Ca concentraiton? -2 |
|
Definition
efflux pumps
reuptake by sarcoplastic reticulum |
|
|
Term
| 3 types of ways to increase intracell Ca? |
|
Definition
-volotage gated channel
-recptor mediated channels
-agonist mediated release |
|
|
Term
| Voltage gated L-type channels are located where? |
|
Definition
| cardiac and smooth muscle cells, SA, AV |
|
|
Term
| in smooth muscle cells what does Calcium bind to in the cytopalsmic reticulum? |
|
Definition
|
|
Term
| what does calmodulin activate? |
|
Definition
| kinase myosin light chain kinase |
|
|
Term
| whcih type of cell has more calcium release from the sarcoplasmic reticulum? |
|
Definition
|
|
Term
| calcium in cardiac myoctes binds to what in cytoplasmic reticulum? |
|
Definition
|
|
Term
| what is the CCB only available as IV |
|
Definition
|
|
Term
non-DHP CCBs affect what area more?
why? |
|
Definition
heart
more open Ca channels |
|
|
Term
DHP- CCBs affect what area more?
why? |
|
Definition
arterial muscle cells->dilation
more closed Ca channels |
|
|
Term
| DHPs have what effects? -3 |
|
Definition
decreased tone
increased flow
increased dilation |
|
|
Term
| what are the Non- DHPs effects -3 |
|
Definition
decrease tone
increase flow
decrease conductance, contraction, rate of heart |
|
|
Term
2 main uses of ?
2 others? |
|
Definition
-HTN, angina pectoris
superventirclular arrythmia, migraine |
|
|
Term
| what CCBs interact with CYP3A4 |
|
Definition
|
|
Term
|
Definition
cardiodepression
hypotension, liver enzyme elevatin, dizziness, constipation |
|
|
Term
| most common ADEs of amlodipine -4 |
|
Definition
gingivial hyperplasia
dizzy, flush, edema |
|
|
Term
| what is the suffix for Alpha 1 blockers |
|
Definition
|
|
Term
| what alpha 1 receptors are involved in alpah blockers? |
|
Definition
| arteries and veins - maybe central |
|
|
Term
| what emd calss decreases LDL and TGs and increases HDL? |
|
Definition
|
|
Term
| what are the main theraputic effects of alpha 1 blockers |
|
Definition
-decrease PR->decrease venous return
-suppression of SNS |
|
|
Term
| why does alpha 1 blockers not cause reflex tachycardia? |
|
Definition
| it decreases sympthetic outflow from CNS |
|
|
Term
| what is med that you need ot watch for orthostatic hypotension on first dose? |
|
Definition
|
|
Term
| what are the alpha 2 agonists? -4 |
|
Definition
clonidine
methyldopa
gunaebenz
guanfacine |
|
|
Term
what is the effec tof aplha 2 agonsts?
what is another proposed effect? |
|
Definition
activate central recpt->decrease SNS outflow;
activate presynaptic recpt- decrease NE secretion |
|
|
Term
| hat med can interact with imidazoline recpotrs? |
|
Definition
|
|
Term
| whcih alpha 2 agonsit do you caution use in renal failure? |
|
Definition
|
|
Term
alpha 2 agonists
-central affect?
-sympathetic/ increased vagal tone effect? |
|
Definition
decreases BP
decreases heart rate |
|
|
Term
| what alternative med can be used to reduce intraocular pressure |
|
Definition
|
|
Term
|
Definition
dry mouth
sedation
sex dysfunction
bradychardia |
|
|
Term
| what medicaiotn is a prodrug? -2 |
|
Definition
|
|
Term
| what is the MOA of methyldopa |
|
Definition
substitutes NE in vesicles
released instead of NE |
|
|
Term
| whcih med has a peak effect delayed fr 6-8 hours? |
|
Definition
|
|
Term
| which medicaiton can cause hemolytic anemia and haptatoxicity? |
|
Definition
|
|
Term
| what meddicaiton is beneficial in preeclampsia? |
|
Definition
|
|
Term
| what is the sympatholytic drug? |
|
Definition
|
|
Term
| what drug should be discontinued at the first sign of depression? |
|
Definition
|
|
Term
|
Definition
retains Na and water
sedation
depression |
|
|
Term
| hydralazine's direct vasodilation main have to do with? |
|
Definition
|
|
Term
| main therpeutic effect of hydralazine |
|
Definition
| decrease PR->powerful stimulation of SNS |
|
|
Term
|
Definition
|
|
Term
| hydralazine can cause what ADES?-4 |
|
Definition
Na and water retenion
headache, flushing, tachycardia |
|
|
Term
what medication steals blood from ischemia region
(dilates coronary arterioles) |
|
Definition
|
|
Term
| hydralazine can increase risk of |
|
Definition
|
|
Term
|
Definition
| activate ATP-k channels->hyperpolarize->relaxation |
|
|
Term
|
Definition
retention of Na and waterr
tachycardia, angina pectoris, MI |
|
|
Term
| which med causes hypertrichosis? |
|
Definition
|
|
