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antifolates are what kind of class |
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Definition
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specificity for cell phases means max effect on _ phase and none on- |
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Definition
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advtg of cell cycle specific drugs-3 |
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Definition
inhibiton of DNA/RNA at clincal dose plateua cell sruvial wiht increase dose minimal leukogeneisis/carincogenesis |
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Term
disadvtg of cell pahse specific drugs-2 |
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Definition
fewer targets little effect on slow grow/stem cells |
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Term
what are the antimetabolits of the CCS group-3 |
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Definition
antifolates purines pyrimidines |
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Definition
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antimetabolites work bc they are struct similar to- |
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Definition
DNA/RNA synth intermediates |
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antimetabolites affect _ synth, and tumor cells are more suscpetible bc |
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Definition
nucleic acid they are dividing more |
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folic acid is which vitamin |
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Definition
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Term
folic acid is used in what base conversion |
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Definition
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Term
folic acid is struct similar to |
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Definition
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Term
MTX and aminopterin inhibit |
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Definition
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Term
what does methotrexate inhibit-3 |
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Definition
purine synth (RNA/DNA) thymidine (tMP) synth methionine, serine, f-met (proteins_ |
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Term
MTX binds to- so it inhibits synth of |
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Definition
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Term
cancers not sensitive to MTX-3 |
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Definition
acute myelo leukemia colon renal |
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Term
cancers sensitive to MTX-4 |
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Definition
acute lymph leukemia nurkitts choriocarcin diffuse lympohma |
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Term
cytotoxic effect of MTX is mediated by- |
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Definition
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Term
what metab MTX into cytotoxic form |
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Definition
folypolygutamyl synthetase |
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Term
polyglutamation is _ depenednet (2) it occurs in tumor and less in nromal cells |
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Definition
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Term
the MTX ->plyglut probbaly account for selective activity of the drug as this is 80% in tumors |
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Definition
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Term
MTX eliminated primary in |
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Definition
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Term
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Definition
IM, oral, IV, intrathecal |
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Definition
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when giving dose of MTX >1000, pt needs to:3 |
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Definition
hydrate void with specific grav <1.01 alkaline urin Ph> 7.5 |
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Term
nephortox of MTX increases with UO<100 and pH<6.5* |
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Definition
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Term
counseling for MTX and NSAID within 36 hrs: -3 |
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Definition
will cause renal, meylo suppres, mucositis |
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Term
what drug slow MTX elmin and prolongs leucovorin-3 |
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Definition
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Term
ADEs of MTX-4 what is a reversible on? |
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Definition
stomatitis nepho, headache, meylo hepatox |
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Term
MTX plasma levels monitored until <0.05 and kidney funct why? |
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Definition
bc PK have high variability |
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Term
systemic tox of MTX correlates with |
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Definition
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Term
Leucovorin rescue dose adjusted to- when is it stoppedd? |
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Definition
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Term
time after dose MTX: 24 hrs, desired level? 48? 72? |
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Definition
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Term
resistance methods for MTX-4 |
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Definition
transport DHFR expression altered DHFR polyglut sythn |
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Term
DHFR amplificaiton is common tumor resistance * |
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Definition
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Term
toxicity of MTX can be reversed by admin- how? |
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Definition
reduced folate doesnt need DHFR activation |
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Term
leuvocorin is converted to _ which bypasses the inhibited MTX reductase |
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Definition
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Term
Leuvocorin is used when- how mnay hrs afterr MTX dose? |
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Definition
MTX dose exceed 10-100 x conventional dose 24-36 hr |
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Term
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Definition
able to use high MTX dose reduced toxic effects folate cofactors |
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Term
what is the multi target antifolate drug? what are its 3 enzymes it inhibits? |
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Definition
pemetrexed thymidylate synthase dihydrofolate reductase GARFT (glycin ribo formyltransferase) |
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Term
pemetrexed prevents formaiton of |
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Definition
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Term
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Definition
mesothelioma non small cell lung cancer |
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toxicity most common wiht antimetab-3 |
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Definition
nausea, mucositis, myelosupp |
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Term
toxicty with chronic methotrexate tox with high dose methotex |
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Definition
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