Term
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Definition
Difference in electrical potential btw. the interior and exterior of a cell |
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Term
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Definition
Resting Membrane Potential (-70mVs) |
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Term
Name two excitable tissues |
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Definition
Muscle cells and Neuron cells |
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Term
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Definition
Separation of charges; RMP |
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Term
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Definition
Membrane potential is reduced; moving to a more positive inside cell |
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Term
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Definition
Membrane returns to the polarized state |
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Term
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Definition
Go below polarized state; more negative than RMP |
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Term
Permeability changes and ion movement during an AP at rest |
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Definition
Membrane potential: -70mVs State of Na+ channels: closed, but able to open if stimulus comes Ion permeability: K+ channels (1 set open) afflux |
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Term
Permeability changes and ion movement during an AP at the rising phase |
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Definition
Membrane potential: becomes more positive State of Na+ channels: Na+ channels open (just a few) Ion permeability: -50mVs-voltage gated channels open |
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Term
Permeability changes and ion movement during an AP at the peak |
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Definition
Membrane potential: +30mVs State of Na+ channels: closed, unable to open Ion permeability: Open second set of K+ channels (afflux) |
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Term
Permeability changes and ion movement during an AP at the falling phase |
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Definition
Membrane potential: moving toward -70mVs State of Na+ channels: closed; unable to open Voltage-gated K+channels: open, affluxing Ion permeability: K+ moves out Na+ no movement |
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Term
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Definition
Short lived local change in the membrane that can be either depolarization or hyperpolarization; decremental |
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Term
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Definition
Only happen on excitable membranes (Muscles/Neurons); brief, rapid reversals of membrane potential (become more + or -); non-decremental |
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Term
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Definition
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Term
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Definition
collect info. from other cells |
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Term
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Definition
Carry message away from soma to another cell |
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Term
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Definition
Reach threshold; determines if theres an AP |
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Term
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Definition
Glial cells, wrap around axon |
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Term
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Definition
Non-myelinated in btw. schwann cells |
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Term
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Definition
Neuron either generates an AP or it does not |
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Term
Node of Ranvier-what is saltatory conduction |
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Definition
impulse jumps from Node to node |
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Term
2 factors which influence the conduction rate |
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Definition
Myelinated or not; Diameter of axon |
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Term
What factors would make the fastest speed of conduction? |
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Definition
Myelinated fat axon; Thicker the axon the faster the electrical message travels |
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Term
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Definition
Autoimmune disease, Destroys myelin |
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Term
First step of The Neural Synapse |
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Definition
Action potential arrives at the nerve terminal |
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Term
Second step of The Neural Synapse |
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Definition
Na+ enters and nerve bouton's membrane depolarizes |
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Term
Third step of The Neural Synapse |
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Definition
Voltage-gated calcium channels open and Ca+ enters (influx) |
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Term
Fourth step of The Neural Synapse |
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Definition
Ca^2+ entry causes release of neurotransmitter form terminal-exocytosis |
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Term
Fifth step of The Neural Synapse |
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Definition
NTs bind to receptors in the post-synaptic membrane |
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Term
Sixth step in The Neural Synapse |
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Definition
Binding of NT to receptor activates chemically gated ion channels |
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Term
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Definition
produces depolarization: more (+) reading, open Na+ channels, Greater permeability, more (+) on inside |
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Term
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Definition
hyperoplarization, increase permeability, K+ moves out, more (-) on inside, Cl- moves in |
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Term
Excitatory Post-synaptic potentials (EPSPs) |
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Definition
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Term
Inhibitory Post-synaptic potentials (IPSPs) |
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Definition
more (-); Cl- goes in or K+ goes out |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
1 cell influences many others |
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Term
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Definition
Receptor, Afferent Neuron, Integrating Neuron, Efferent Neuron, Effector |
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Term
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Definition
detect change in environment |
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Term
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Definition
carry an AP; sensory; take info. into the CNS |
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Term
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Definition
processing; spinal cord or brain; make response |
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Term
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Definition
motor; effector organ; carry info. away from the CNS |
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Term
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Definition
muscle/gland that carries out the required response |
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Term
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Definition
Acetylcholine; for somatic motor neurons; ANS |
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Term
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Definition
bind muscarin; found in plasma membrane of cardiac and smooth muscle cells and some glands |
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Term
G-protein operated channel |
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Definition
protein that's a receptor; ABG complex binds ACh, activates a different protein and either the Beta or Alpha complex migrates |
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Term
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Definition
binds nicotine; found on skeletal muscle, brain and ganglia |
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Term
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Definition
5 polypeptide subunits that enclose an ion channel |
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Term
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Definition
Acetylcholinesterase; enzyme protein that binds ACh and inactivates it by chopping ACh in half; located in post-synaptic membrane |
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Term
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Definition
NT in brainstem; regulates mood, behavior, appetite, and cerebral circulation; insufficient amount=depressed |
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Term
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Definition
regulates movement and emotion |
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Term
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Definition
secreted by adrenal medulla upon stimulation of CNS in response to stress, anger, fear, and increases HR, BP, cardiac output |
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Term
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Definition
has such effects as constricting blood vessels, raising blood pressure, and dilating bronchi. |
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Term
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Definition
located in the PNS; wrap around axon; increase conduction rate |
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Term
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Definition
located in the PNS; support cells for neurons in part of Afferent neuron |
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Term
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Definition
located in the CNS; form myelin sheath in the CNS; wrap around axon; increase electrical conduction |
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Term
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Definition
located in the CNS; small; many processes; phagocytosis-find debris and get rid of it |
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Term
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Definition
located in the CNS; sitting on top of tissues w/a lot of capillaries; get nutrients from capillaries, process it, and make CFS, and circulate it by cilia |
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Term
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Definition
located in the CNS; nurse cells; take up NTs, put back in neuron and recycle it; need for formation of synapses in the CNS; close capillary cells to form tight junctions (BBB), no filtration; control extracellular fluid-ion concentration |
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Term
Organization of the Nervous System |
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Definition
One fully integrated system w/divisions based on differences in structure, location, and function |
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Term
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Definition
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Term
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Definition
Afferent (Sensory) Division, Efferent (Motor) Division-splits into the Autonomic (Involuntary) which splits into Sympathetic and Parasympathetic. Efferent (Motor) Division also splits into Somatic (Muscle motor) |
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Term
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Definition
Bone (skull), Glial Cells, Meninges, CSF, BBB, Plasticity |
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Term
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Definition
bound w/in CNS; form compartments; Dura Mater, Arachnoid Mater, Subarachnoid space (contains CFS), Pia Mater |
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Term
|
Definition
Cushion circulator system-getting rid of waste, bring in nutrients; Produce 500mL-800mL/day, constantly producing and draining into venus blood; Buoyancy-floating |
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Term
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Definition
Blood Brain Barrier; no pores btw. cells; no filtration; ependymal (surface cells) controls what moves in/out (nutrients/wastes); good protection |
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Term
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Definition
functionally remodel; ability to form new neural pathways |
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Term
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Definition
Medulla Oblongata; Descending/Ascending nerve tracts (communication btw. brain/spinal cord); Cranial nerves; DIRECT control of cardiovascular system; Autonomic reflexes (some); Sleep centers; Respiratory-works w/pons |
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Term
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Definition
Reticular Activating System; Projection fibers, you control what moves through |
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Term
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Definition
Electroencephalogram; Clinical tool-diagnois different cerebral functions; Distinguish different levels of sleep; Legal tool-determine if somebody is dead |
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Term
Sleep in an active process |
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Definition
Level of brain activity is not reduced |
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Term
|
Definition
Non rapid eye movement; slow wave sleep; makes up 80% of sleep time |
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Term
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Definition
Rapid Eye Movement; 20% of sleep time; gets longer w/each cycle |
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Term
|
Definition
Muscle tone; HR + BP + RR =minor reductions; No dreaming; Easily awakened by external stimuli |
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Term
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Definition
No muscle tone; Irregular HR + BP; Dreaming; Not awaken by external stimuli-can wake self |
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Term
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Definition
Time for brain to recharge/restore energy level |
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Term
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Definition
Somebody who falls asleep randomly, then wakes up and have no clue they fell asleep |
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Term
|
Definition
decrease quantity and decrease quality; not getting enough REM |
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Term
|
Definition
back (posterior); processing visual info. |
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Term
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Definition
lateral sides; hearing; some memory storage of visual and auditory |
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Term
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Definition
Somatosensory sensation from skin, muscles, tendons, and joints |
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Term
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Definition
voluntary motor; speaking ability; elaborate thought-being able to reason; personality |
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Term
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Definition
not seen from surface; store long term memory |
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Term
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Definition
speaking ability; can comprehend speech, can't speak (difficulty speaking) |
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Term
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Definition
deal w/language; spoken and written; not working-speak, nobody can understand what you say or you think you know what you're saying, but others don't know what you say |
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Term
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Definition
map of motor areas of cerebral cortex (fine motor) |
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Term
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Definition
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Term
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Definition
Integrating center for all senses, but smell |
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Term
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Definition
Link btw. the ANS and the endocrine system |
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Term
7 functions of the Hypothalamus |
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Definition
Control body temp. (thermoreceptors); Controls your thirst/urine output; Controls your food intake; controls anterior pituitary hormone secretion; produces ADH & oxytocin; INDIRECT control of cardiovascular system-heart, blood pressure in vesicles; role in emotional and behavioral patterns |
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Term
|
Definition
a ring of forebrain structures that surround the brain stem and these structures are interconnected by intricate neuronal pathways; center for basic emotional drives-little conscious control over our emotions |
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Term
Limbic Systems-basic characteristics |
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Definition
anger, fear, anxiety, discouragement, happiness, food center, goal orientated behavior-reward/punishment, basic survival, survival of species-sexual behavior |
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Term
|
Definition
acquiring knowledge/skills |
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Term
|
Definition
Rapid retrieval; Limited amount of storage; No permanent structural changes at neural synapses; Memory fades, goes away, and is forgotten |
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Term
|
Definition
Slower retrieval; Unlimited storage; Making permanent changes at synapses; Last long time |
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Term
|
Definition
"swelling"; respiratory control center-rate and depth |
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Term
Cerebellum-3 basic functions |
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Definition
Enhances muscle tone-posture; Contributes to maintenance of balance; Coordinated skills-voluntary movements |
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Term
|
Definition
Integration of basic reflexes; Link for transmission of information (body to brain, brain to body) |
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Term
|
Definition
afferent neurons-sensory info. into CNS |
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Term
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Definition
efferent neuron-motor info. out of CNS |
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Term
|
Definition
both sensory and motor neurons mixed |
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Term
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Definition
(swelling of nervous tissue; posterior) soma of many unipolar sensory neurons |
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Term
|
Definition
Unconscious motor response to a sensory stimulus-happens automatically |
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Term
Name 2 basic types of reflexes |
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Definition
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Term
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Definition
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Term
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Definition
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Term
|
Definition
adapt slowly or not at all to a constant stimulus; Ex) Nocireceptors, BP receptors, Muscle/stretch receptors, Joint proprio receptors |
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Term
|
Definition
adapt rapidly to a constant stimulus |
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|
Term
What is the relationship of receptor field size in relation to receptor density? |
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Definition
More receptors in a region -> smaller field size per receptor -> greater discrimination in region Ex) Fingers/Lips have more receptors, Back has less receptors |
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Term
Afferent Input- Unconscious |
|
Definition
info. not always aware of |
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Term
|
Definition
Somatic sensation-regards to muscle Somesthetic sensation-body feelings Proprioception-stretch receptors in tendons, ligaments, joints, skeletal muscle |
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Term
|
Definition
Conscious interpretation of the external world as created by the brain from a pattern of nerve impulses |
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Term
What does perception not equal reality? |
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Definition
Limited # of receptor types; Limited range on receptors; Cerebral cortex manipulates/suppresses/ignores/excentuates data |
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Term
|
Definition
Heat-thermoreceptors; skin, muscle Light-photoreceptors; retina Sound-mechaical; organ of corgi Pressure-mechanical; arteries, brain, skin, joints Chemical-chemoreceptors; taste, smell, kidneys Pain-nocireceptors Osmolarity-read concentration of solutes |
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Term
|
Definition
Stimulus of specific form of energy to which a given receptor is sensitive |
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Term
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Definition
stimulation another way; some sensations are based on 2 or more stimuli |
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Term
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Definition
Cardiac/Smooth Muscle; Endocrine/Exocrine Glands |
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|
Term
Sympathetic dominates under what conditions? |
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Definition
"Fight-or-Flight"; located in the Thoracolumbar division |
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|
Term
Parasympathetic dominates under what conditions? |
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Definition
"Good House Keeping"; located in the Crainalsacral division |
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Term
|
Definition
2 neuron chain from CNS to the effector organ, neuron 1 has cell body in CNS and neuron 2 has cell body in peripheral ganglia |
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Term
Effects of the ANS on the Iris |
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Definition
Sympathetic-dilate; Parasympathetic-normal |
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Term
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Definition
Sympathetic-increases; Parasympathetic-decreases |
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|
Term
Effects of the ANS on the Respiratory rate |
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Definition
Sympathetic-increases; Parasympathetic-decreases |
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|
Term
Effects of the ANS on Rate of digestion |
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Definition
Sympathetic-decreases; Parasympathetic-increases |
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|
Term
Effects of the ANS on Urinary Filtration |
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Definition
Sympathetic-decreases; Parasympathetic-increases |
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|
Term
Effects of the ANS on Energy deposition |
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Definition
Sympathetic-decreases; Parasympathetic-increases |
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|
Term
Effects of the ANS on Energy Mobilization |
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Definition
Sympathetic-increases; Parasympathetic-decreases |
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Term
|
Definition
sympathetic and parasympathetic |
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Term
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Definition
Parasympathetic and Sympathetic work together; Ex) HR: Para.-decreases, Sym.-increases |
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Term
|
Definition
same effects; Ex) salivary glands |
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Term
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Definition
both work together for 1 given reaction |
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Term
Regions of CNS control over Autonomic activities |
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Definition
Autonomic reflexes-internal (automatic) Medulla- most direct control Hypothalamus- integrator Limbic system- emotions Prefrontal association- personality |
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Term
|
Definition
Skeletal Muscle; Smooth Muscle; Cardiac Muscle |
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Term
|
Definition
tied to bones; makes lever system; voluntary; long, thick, cylindrical fibers that relax relatively rapidly; striated-multinucleated |
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Term
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Definition
Found in walls of hollow organs/tubes; involuntary; short, thin, spindle shaped, 1 nucleus, contract/relax relatively slowly; non-striated |
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Term
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Definition
Heart; striated; involuntary; branched; 1 nucleus/cell; inoculated discs |
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Term
|
Definition
one motor neuron plus all the muscle fibers it innervates; size varies depending on the use of the muscle |
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Term
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Definition
spatial summation; increase recruitment of motor unit by increasing strength; increase strength of contraction by a greater # of units activated/change size of motor units |
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Term
|
Definition
time (increased frequency); build up tension; contraction w/no relaxation |
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|
Term
Energy sources for muscle activity |
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Definition
ATP Creatine phosphate Glycolysis-2ATP/glucose Oxidative phosphorylation-chemiosmosis, Kreb cycle and ETC make large amounts of ATP |
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Term
|
Definition
to power cross bridge; break myosin/actin bond for attachment; pump Ca^2+ back into SR |
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Term
Muscle adaptation in response to use: Regular aerobic exercise |
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Definition
Increase #/size of mitochondria; Increase ATP production from oxidative phosphorlation; Increase myoglobin content-stores O_2; decrease lactic acid production; increase fuel burning fats; increase the # of circulatory pathways |
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|
Term
Muscle adaptation in response to use: short duration, high intensity exercise |
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Definition
hypertrophy-muscle cell increase, because cell size increases; increases strength which increases # of myofibrils |
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|
Term
Muscle adaptation in response to use: no use or denervation |
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Definition
atrophy-decrease muscle size-proteins are breaking down |
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|
Term
Muscle adaptation in response to use: Muscular dystrophy |
|
Definition
hereditary, pathological disease progressive degeneration of contractile tissue-muscle disappearing (muscle is replaced by fat) |
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|
Term
Three types of muscle fibers |
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Definition
Red-slow-twitch; White-fast-twitch; Red-fast-twitch |
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Term
|
Definition
Oxidative; small; myoglobin; increase # of mitochondria; slow rate of contraction; resistant to fatigue; aerobic respiration; found in lower back |
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Term
|
Definition
glycolytic; double the diameter; no myoglobin; decrease # of mitochondria; anaerobic; increase storage of glycogen; fast contraction; fatigue easily; found in arms |
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Term
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Definition
intermediate; inbtw. size; myoglobin; increase # of mitochondria; aerobic; contract rapidly; fatigue-but don't tire to fast; found in legs |
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Term
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Definition
no sarcomere units; no troponin and no tropomyosin; Ca^2+ doesn't cause a physical change, causes a chemical reaction that cause phosphorylation of myosin, so myosin can bind to actin and work |
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Term
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Definition
neurogenic; functions like skeletal muscle, but innervated by autonomic neurons; Ex) eye muscles, large airways in lungs, large blood vessels, arrestor pili |
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|
Term
Single-unit smooth muscle |
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Definition
functional syncytium-cells which work as a unit mechanically and electrically; Ex) uterus during labor, digestive, reproductive, and urinary tracts, small blood vessels; heart has two |
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Term
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Definition
Left and Right atria; Left and Right ventricles (left has thicker myocardium); Interatrial septum; Interventricular septum; Tricuspid valve; Bicuspid valve |
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|
Term
The heart has two separate pumps |
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Definition
which pump equal amounts of blood simultaneously |
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Term
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Definition
low pressure system; receives and pumps blood low in oxygen |
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Term
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Definition
high pressure system; left heart-receives and pumps blood high in oxygen |
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Term
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Definition
cells electrically/mechanically connected; work as a unit |
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Term
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Definition
Atrial unit and Ventricular unit |
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Term
Be able to follow a drop of blood through one full circuit through the body. |
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Definition
Superior/Inferior Vena Cava, Right atrium, Tricuspid Valve, Right ventricle, Pulmonary Semilunar Valves, Pulmonary Arteries, Lungs, Pulmonary Veins, Left Atrium, Bicuspid Valve, Left Ventricle, Aortic Semilunar Valves, Aorta, Arteries, Arterioles, Capillaries, Venules, Veins |
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|
Term
Special adaptation for cardiac tissue |
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Definition
Intercalated discs-Desmosomes (rives cells together, makes them strong and stretchy) Gap Junctions (allow rapid movement of ions through the cardiac tissue) |
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|
Term
What is the purpose of the fibrous skeleton on the heart? |
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Definition
Stops the conduction of electricity from the atrial tissue directly into the ventricular tissue. |
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Term
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Definition
muscular layer of the heart wall; 99% contractile; 1% auto rhythmic-generate AP all on their own |
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Term
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Definition
In the upper wall of the right atrium, close to the superior vena cava; 70-80 times per minute |
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Term
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Definition
In the lower interatrial septum; 40-60 times per minute |
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Term
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Definition
In the upper inter ventricular septum; 15-40 times per minute |
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Term
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Definition
Extend through the inter ventricular septum |
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Term
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Definition
Extends into the walls of the myocardium of the ventricles |
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Term
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Definition
abnormal rate set-purkinje fibers firing 120x's/min. |
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|
Term
Why does there have to be an AV nodal delay? |
|
Definition
Atrial chambers need to contract, emptying into the ventricles |
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|
Term
Which site is in control in a normal healthy heart? |
|
Definition
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|
Term
AP in contractile cardiac muscle cells |
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Definition
RMP, Rapid depolarization-rapid v.gated Na+ channels open, influx, Long Plateau at Peak Potential-v.gated Na+channels close, Ca^2+ influx, Repolarization-Ca^2+ colse, K+ open/afflux |
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|
Term
What causes the plateau during an AP in contractile cardiac muscle? |
|
Definition
Refractory Period-prevents initiation of a second AP until resting potential is resored |
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|
Term
Why is tetanus impossible in the heart? |
|
Definition
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|
Term
First sequence in the Cardiac Cycle |
|
Definition
Blood continuously flows into both atria |
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|
Term
Second sequence in the Cardiac Cycle |
|
Definition
The pressure of incoming blood opens the right and left AV valves |
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|
Term
|
Definition
Two thirds of the atrial blood flows passively into the ventricles |
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|
Term
Fourth sequence in the CC |
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Definition
The atria contract to pump the remaining blood into the ventricles |
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Term
|
Definition
The atria relax, and the ventricles begin to contract |
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|
Term
|
Definition
The right and left AV valve are closed, and the aortic and pulmonary semilunar valves are opened |
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|
Term
Seventh sequence in the CC |
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Definition
Ventricular contraction pumps blood into the arteries |
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|
Term
Eighth sequence in the CC |
|
Definition
The ventricles relax, and the semilunar valves are closed |
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|
Term
Electrocardiogram (ECG/EKG) |
|
Definition
records spread of electrical activity through the heart as it is depolarized and repolarized |
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Term
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Definition
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Term
|
Definition
internodal delay; atria emptying |
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Term
|
Definition
ventricular depolarization; atrial repolarization |
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Term
|
Definition
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Term
|
Definition
ventricular repolarization |
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Term
|
Definition
atrials/ventricles filling |
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Term
|
Definition
rate over 100 beats/min. in resting state |
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|
Term
|
Definition
less than 60 beats/min. in resting state |
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|
Term
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Definition
turbulent flow at abnormal times in the cardiac cycle |
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Term
|
Definition
Myofibril, Mitochondria, Cytosol, Triad, T-tubule (cont. of sarcolemma deep into the cell), Terminal Cisternae, Sarcoplasmic reticulum (organelle wraps around myofibrils), Nucleus, Sarcolemma (cell membrane), Muscle cell (fibers) |
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|
Term
Steps required to make a muscle contraction-sliding filament theory |
|
Definition
1) Na+ enters the muscle fiber causing depolarization 2) Wave of depolarization is transmitted into the interior of the fiber by T-tubules 3) Results in the release of calcium ions from the SR 4) Ca^2+ binds to troponin in thin filament 5) Causes tropomyosin to shift and expose active sites on the actin 6) Exposed active sites can now bind w/ myosin heads 7) ATP binds to the myosin head causing head to cock 8) Cross bridge forms btw. actin and myosin 9) Myosin head pushed the actin toward the center of the sarcomere 10) Thin filament slides over the thick filament 11) Another ATP molecule binds to the myosin head and results in the release of the cross bridge *Cont. as long as there is Nervous stimulation* |
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Term
|
Definition
Sensory neurons, Interneurons, Motor neurons |
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Term
|
Definition
Neurons w/in the CNS that do not extend into the peripheral nervous system. Interposed btw. sensory (afferent) and motor (efferent) neurons |
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Term
|
Definition
efferent neuron that conducts action potentials away from the CNS to effector organs (muscles/glands). Forms the ventral roots of spinal nerves |
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Term
|
Definition
afferent neuron that conducts impulses from peripheral sensory organs into the CNS |
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Term
|
Definition
itching, tingling, numbness, pain |
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Term
|
Definition
response; autonomic (sympathetic/parasympathetic) |
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Term
|
Definition
receptor/neuron that binds/secrets ACh |
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Term
|
Definition
binds/secretes Epinephrin or Norepinephrine; act via G-proteins |
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Term
|
Definition
excitatory; vasoconstriction of blood cells |
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Term
|
Definition
only found on the heart/kidney; excitatory; increase rate/force of contraction of heart |
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Term
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Definition
inhibitory; Bronchioles, Intestines; dilates airways of lungs |
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Term
Role of the adrenal gland (medulla) in the sympathetic division |
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Definition
control of the cardiovascular, respiratory, digestive, urinary, reproductive systems, etc. |
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