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Exam 2
Ch.7-13
206
Physiology
Undergraduate 2
10/25/2012

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Term
Membrane Potential
Definition
Difference in electrical potential btw. the interior and exterior of a cell
Term
RMP
Definition
Resting Membrane Potential (-70mVs)
Term
Name two excitable tissues
Definition
Muscle cells and Neuron cells
Term
Polarization
Definition
Separation of charges; RMP
Term
Depolarization
Definition
Membrane potential is reduced; moving to a more positive inside cell
Term
Repolarization
Definition
Membrane returns to the polarized state
Term
Hyperpolarization
Definition
Go below polarized state; more negative than RMP
Term
Permeability changes and ion movement during an AP at rest
Definition
Membrane potential: -70mVs
State of Na+ channels: closed, but able to open if stimulus comes
Ion permeability: K+ channels (1 set open) afflux
Term
Permeability changes and ion movement during an AP at the rising phase
Definition
Membrane potential: becomes more positive
State of Na+ channels: Na+ channels open (just a few)
Ion permeability: -50mVs-voltage gated channels open
Term
Permeability changes and ion movement during an AP at the peak
Definition
Membrane potential: +30mVs
State of Na+ channels: closed, unable to open
Ion permeability: Open second set of K+ channels (afflux)
Term
Permeability changes and ion movement during an AP at the falling phase
Definition
Membrane potential: moving toward -70mVs
State of Na+ channels: closed; unable to open
Voltage-gated K+channels: open, affluxing
Ion permeability: K+ moves out Na+ no movement
Term
Graded Potentials
Definition
Short lived local change in the membrane that can be either depolarization or hyperpolarization; decremental
Term
Action Potentials
Definition
Only happen on excitable membranes (Muscles/Neurons); brief, rapid reversals of membrane potential (become more + or -); non-decremental
Term
Cell body/soma
Definition
Nucleus, nucleoli
Term
Dendrites
Definition
collect info. from other cells
Term
Axon
Definition
Carry message away from soma to another cell
Term
Axon hillock
Definition
Reach threshold; determines if theres an AP
Term
Schwann cells
Definition
Glial cells, wrap around axon
Term
Nodes of Ranvier
Definition
Non-myelinated in btw. schwann cells
Term
All or None Law
Definition
Neuron either generates an AP or it does not
Term
Node of Ranvier-what is saltatory conduction
Definition
impulse jumps from Node to node
Term
2 factors which influence the conduction rate
Definition
Myelinated or not; Diameter of axon
Term
What factors would make the fastest speed of conduction?
Definition
Myelinated fat axon; Thicker the axon the faster the electrical message travels
Term
Multiple Sclerosis
Definition
Autoimmune disease, Destroys myelin
Term
First step of The Neural Synapse
Definition
Action potential arrives at the nerve terminal
Term
Second step of The Neural Synapse
Definition
Na+ enters and nerve bouton's membrane depolarizes
Term
Third step of The Neural Synapse
Definition
Voltage-gated calcium channels open and Ca+ enters (influx)
Term
Fourth step of The Neural Synapse
Definition
Ca^2+ entry causes release of neurotransmitter form terminal-exocytosis
Term
Fifth step of The Neural Synapse
Definition
NTs bind to receptors in the post-synaptic membrane
Term
Sixth step in The Neural Synapse
Definition
Binding of NT to receptor activates chemically gated ion channels
Term
Excitatory Synapse
Definition
produces depolarization: more (+) reading, open Na+ channels, Greater permeability, more (+) on inside
Term
Inhibitory Synapse
Definition
hyperoplarization, increase permeability, K+ moves out, more (-) on inside, Cl- moves in
Term
Excitatory Post-synaptic potentials (EPSPs)
Definition
more (+); Na+ in
Term
Inhibitory Post-synaptic potentials (IPSPs)
Definition
more (-); Cl- goes in or K+ goes out
Term
Temporal Summation
Definition
summation over time
Term
Spatial summation
Definition
Summation over space
Term
Convergence
Definition
input into 1 cell
Term
Divergence
Definition
1 cell influences many others
Term
Reflex arc
Definition
Receptor, Afferent Neuron, Integrating Neuron, Efferent Neuron, Effector
Term
Receptor
Definition
detect change in environment
Term
Afferent pathway
Definition
carry an AP; sensory; take info. into the CNS
Term
Integrating Center
Definition
processing; spinal cord or brain; make response
Term
Efferent pathway
Definition
motor; effector organ; carry info. away from the CNS
Term
Effector
Definition
muscle/gland that carries out the required response
Term
ACh
Definition
Acetylcholine; for somatic motor neurons; ANS
Term
Muscarinic receptors
Definition
bind muscarin; found in plasma membrane of cardiac and smooth muscle cells and some glands
Term
G-protein operated channel
Definition
protein that's a receptor; ABG complex binds ACh, activates a different protein and either the Beta or Alpha complex migrates
Term
Nicotinic Receptor
Definition
binds nicotine; found on skeletal muscle, brain and ganglia
Term
Ligand-operated channel
Definition
5 polypeptide subunits that enclose an ion channel
Term
AChE
Definition
Acetylcholinesterase; enzyme protein that binds ACh and inactivates it by chopping ACh in half; located in post-synaptic membrane
Term
Serotinin
Definition
NT in brainstem; regulates mood, behavior, appetite, and cerebral circulation; insufficient amount=depressed
Term
Dopamine
Definition
regulates movement and emotion
Term
Epinephrine
Definition
secreted by adrenal medulla upon stimulation of CNS in response to stress, anger, fear, and increases HR, BP, cardiac output
Term
Norepinephrine
Definition
has such effects as constricting blood vessels, raising blood pressure, and dilating bronchi.
Term
Schwann Cells
Definition
located in the PNS; wrap around axon; increase conduction rate
Term
Satellite cells
Definition
located in the PNS; support cells for neurons in part of Afferent neuron
Term
Oligodendrocytes
Definition
located in the CNS; form myelin sheath in the CNS; wrap around axon; increase electrical conduction
Term
Microglia
Definition
located in the CNS; small; many processes; phagocytosis-find debris and get rid of it
Term
Ependymal
Definition
located in the CNS; sitting on top of tissues w/a lot of capillaries; get nutrients from capillaries, process it, and make CFS, and circulate it by cilia
Term
Astrocytes
Definition
located in the CNS; nurse cells; take up NTs, put back in neuron and recycle it; need for formation of synapses in the CNS; close capillary cells to form tight junctions (BBB), no filtration; control extracellular fluid-ion concentration
Term
Organization of the Nervous System
Definition
One fully integrated system w/divisions based on differences in structure, location, and function
Term
CNS
Definition
Brain and Spinal Cord
Term
PNS
Definition
Afferent (Sensory) Division, Efferent (Motor) Division-splits into the Autonomic (Involuntary) which splits into Sympathetic and Parasympathetic. Efferent (Motor) Division also splits into Somatic (Muscle motor)
Term
Brain Protection
Definition
Bone (skull), Glial Cells, Meninges, CSF, BBB, Plasticity
Term
Meninges-membranes
Definition
bound w/in CNS; form compartments; Dura Mater, Arachnoid Mater, Subarachnoid space (contains CFS), Pia Mater
Term
CSF-circulatory system
Definition
Cushion circulator system-getting rid of waste, bring in nutrients; Produce 500mL-800mL/day, constantly producing and draining into venus blood; Buoyancy-floating
Term
BBB
Definition
Blood Brain Barrier; no pores btw. cells; no filtration; ependymal (surface cells) controls what moves in/out (nutrients/wastes); good protection
Term
Plasticity
Definition
functionally remodel; ability to form new neural pathways
Term
Brain Stem-Functions
Definition
Medulla Oblongata; Descending/Ascending nerve tracts (communication btw. brain/spinal cord); Cranial nerves; DIRECT control of cardiovascular system; Autonomic reflexes (some); Sleep centers; Respiratory-works w/pons
Term
RAS
Definition
Reticular Activating System; Projection fibers, you control what moves through
Term
EEG-3 major uses
Definition
Electroencephalogram; Clinical tool-diagnois different cerebral functions; Distinguish different levels of sleep; Legal tool-determine if somebody is dead
Term
Sleep in an active process
Definition
Level of brain activity is not reduced
Term
NREM
Definition
Non rapid eye movement; slow wave sleep; makes up 80% of sleep time
Term
REM
Definition
Rapid Eye Movement; 20% of sleep time; gets longer w/each cycle
Term
NREM traits
Definition
Muscle tone; HR + BP + RR =minor reductions; No dreaming; Easily awakened by external stimuli
Term
REM traits
Definition
No muscle tone; Irregular HR + BP; Dreaming; Not awaken by external stimuli-can wake self
Term
Why do we need sleep?
Definition
Time for brain to recharge/restore energy level
Term
Narcolepsy
Definition
Somebody who falls asleep randomly, then wakes up and have no clue they fell asleep
Term
Insomnia
Definition
decrease quantity and decrease quality; not getting enough REM
Term
Occipital Lobe
Definition
back (posterior); processing visual info.
Term
Temporal Lobe
Definition
lateral sides; hearing; some memory storage of visual and auditory
Term
Parietal Lobe
Definition
Somatosensory sensation from skin, muscles, tendons, and joints
Term
Frontal Lobe
Definition
voluntary motor; speaking ability; elaborate thought-being able to reason; personality
Term
Insula
Definition
not seen from surface; store long term memory
Term
Broca's area
Definition
speaking ability; can comprehend speech, can't speak (difficulty speaking)
Term
Wernicke's area
Definition
deal w/language; spoken and written; not working-speak, nobody can understand what you say or you think you know what you're saying, but others don't know what you say
Term
Precentral gyrus
Definition
map of motor areas of cerebral cortex (fine motor)
Term
Postcentral gyrus
Definition
behind central sulcus
Term
Thalamus
Definition
Integrating center for all senses, but smell
Term
Hypothalamus
Definition
Link btw. the ANS and the endocrine system
Term
7 functions of the Hypothalamus
Definition
Control body temp. (thermoreceptors); Controls your thirst/urine output; Controls your food intake; controls anterior pituitary hormone secretion; produces ADH & oxytocin; INDIRECT control of cardiovascular system-heart, blood pressure in vesicles; role in emotional and behavioral patterns
Term
Limbic System
Definition
a ring of forebrain structures that surround the brain stem and these structures are interconnected by intricate neuronal pathways; center for basic emotional drives-little conscious control over our emotions
Term
Limbic Systems-basic characteristics
Definition
anger, fear, anxiety, discouragement, happiness, food center, goal orientated behavior-reward/punishment, basic survival, survival of species-sexual behavior
Term
Learning
Definition
acquiring knowledge/skills
Term
Short term memory
Definition
Rapid retrieval; Limited amount of storage; No permanent structural changes at neural synapses; Memory fades, goes away, and is forgotten
Term
Long term memory
Definition
Slower retrieval; Unlimited storage; Making permanent changes at synapses; Last long time
Term
Pons
Definition
"swelling"; respiratory control center-rate and depth
Term
Cerebellum-3 basic functions
Definition
Enhances muscle tone-posture; Contributes to maintenance of balance; Coordinated skills-voluntary movements
Term
Spinal Cord-functions
Definition
Integration of basic reflexes; Link for transmission of information (body to brain, brain to body)
Term
Dorsal root
Definition
afferent neurons-sensory info. into CNS
Term
Ventral root
Definition
efferent neuron-motor info. out of CNS
Term
Spinal nerve
Definition
both sensory and motor neurons mixed
Term
Dorsal root ganglion
Definition
(swelling of nervous tissue; posterior) soma of many unipolar sensory neurons
Term
Reflexes
Definition
Unconscious motor response to a sensory stimulus-happens automatically
Term
Name 2 basic types of reflexes
Definition
Simple and Acquired
Term
Simple reflex
Definition
unlearned
Term
Acquired reflex
Definition
learned; conditioned
Term
Tonic receptors
Definition
adapt slowly or not at all to a constant stimulus; Ex) Nocireceptors, BP receptors, Muscle/stretch receptors, Joint proprio receptors
Term
Phasic receptors
Definition
adapt rapidly to a constant stimulus
Term
What is the relationship of receptor field size in relation to receptor density?
Definition
More receptors in a region -> smaller field size per receptor -> greater discrimination in region
Ex) Fingers/Lips have more receptors, Back has less receptors
Term
Afferent Input- Unconscious
Definition
info. not always aware of
Term
Afferent Input-Conscious
Definition
Somatic sensation-regards to muscle
Somesthetic sensation-body feelings
Proprioception-stretch receptors in tendons, ligaments, joints, skeletal muscle
Term
Perception
Definition
Conscious interpretation of the external world as created by the brain from a pattern of nerve impulses
Term
What does perception not equal reality?
Definition
Limited # of receptor types; Limited range on receptors; Cerebral cortex manipulates/suppresses/ignores/excentuates data
Term
Receptors-types
Definition
Heat-thermoreceptors; skin, muscle
Light-photoreceptors; retina
Sound-mechaical; organ of corgi
Pressure-mechanical; arteries, brain, skin, joints
Chemical-chemoreceptors; taste, smell, kidneys
Pain-nocireceptors
Osmolarity-read concentration of solutes
Term
Adequate stimulus
Definition
Stimulus of specific form of energy to which a given receptor is sensitive
Term
Alternative stimulus
Definition
stimulation another way; some sensations are based on 2 or more stimuli
Term
Effector organs
Definition
Cardiac/Smooth Muscle; Endocrine/Exocrine Glands
Term
Sympathetic dominates under what conditions?
Definition
"Fight-or-Flight"; located in the Thoracolumbar division
Term
Parasympathetic dominates under what conditions?
Definition
"Good House Keeping"; located in the Crainalsacral division
Term
Structure of the ANS
Definition
2 neuron chain from CNS to the effector organ, neuron 1 has cell body in CNS and neuron 2 has cell body in peripheral ganglia
Term
Effects of the ANS on the Iris
Definition
Sympathetic-dilate; Parasympathetic-normal
Term
Effects of the ANS on HR
Definition
Sympathetic-increases; Parasympathetic-decreases
Term
Effects of the ANS on the Respiratory rate
Definition
Sympathetic-increases; Parasympathetic-decreases
Term
Effects of the ANS on Rate of digestion
Definition
Sympathetic-decreases; Parasympathetic-increases
Term
Effects of the ANS on Urinary Filtration
Definition
Sympathetic-decreases; Parasympathetic-increases
Term
Effects of the ANS on Energy deposition
Definition
Sympathetic-decreases; Parasympathetic-increases
Term
Effects of the ANS on Energy Mobilization
Definition
Sympathetic-increases; Parasympathetic-decreases
Term
Dual innervation
Definition
sympathetic and parasympathetic
Term
Antagonistic effects
Definition
Parasympathetic and Sympathetic work together; Ex) HR: Para.-decreases, Sym.-increases
Term
Complimentary effects
Definition
same effects; Ex) salivary glands
Term
Cooperative
Definition
both work together for 1 given reaction
Term
Regions of CNS control over Autonomic activities
Definition
Autonomic reflexes-internal (automatic)
Medulla- most direct control
Hypothalamus- integrator
Limbic system- emotions
Prefrontal association- personality
Term
Types of muscle cells
Definition
Skeletal Muscle; Smooth Muscle; Cardiac Muscle
Term
Skeletal muscle
Definition
tied to bones; makes lever system; voluntary; long, thick, cylindrical fibers that relax relatively rapidly; striated-multinucleated
Term
Smooth muscle
Definition
Found in walls of hollow organs/tubes; involuntary; short, thin, spindle shaped, 1 nucleus, contract/relax relatively slowly; non-striated
Term
Cardiac muscle
Definition
Heart; striated; involuntary; branched; 1 nucleus/cell; inoculated discs
Term
Motor unit
Definition
one motor neuron plus all the muscle fibers it innervates; size varies depending on the use of the muscle
Term
Motor unit recruitment
Definition
spatial summation; increase recruitment of motor unit by increasing strength; increase strength of contraction by a greater # of units activated/change size of motor units
Term
Temporal summation
Definition
time (increased frequency); build up tension; contraction w/no relaxation
Term
Energy sources for muscle activity
Definition
ATP
Creatine phosphate
Glycolysis-2ATP/glucose
Oxidative phosphorylation-chemiosmosis, Kreb cycle and ETC make large amounts of ATP
Term
ATP is required for
Definition
to power cross bridge; break myosin/actin bond for attachment; pump Ca^2+ back into SR
Term
Muscle adaptation in response to use: Regular aerobic exercise
Definition
Increase #/size of mitochondria; Increase ATP production from oxidative phosphorlation; Increase myoglobin content-stores O_2; decrease lactic acid production; increase fuel burning fats; increase the # of circulatory pathways
Term
Muscle adaptation in response to use: short duration, high intensity exercise
Definition
hypertrophy-muscle cell increase, because cell size increases; increases strength which increases # of myofibrils
Term
Muscle adaptation in response to use: no use or denervation
Definition
atrophy-decrease muscle size-proteins are breaking down
Term
Muscle adaptation in response to use: Muscular dystrophy
Definition
hereditary, pathological disease progressive degeneration of contractile tissue-muscle disappearing (muscle is replaced by fat)
Term
Three types of muscle fibers
Definition
Red-slow-twitch; White-fast-twitch; Red-fast-twitch
Term
Red-slow-twitch
Definition
Oxidative; small; myoglobin; increase # of mitochondria; slow rate of contraction; resistant to fatigue; aerobic respiration; found in lower back
Term
White-fast-twitch
Definition
glycolytic; double the diameter; no myoglobin; decrease # of mitochondria; anaerobic; increase storage of glycogen; fast contraction; fatigue easily; found in arms
Term
Red-fast-twitch
Definition
intermediate; inbtw. size; myoglobin; increase # of mitochondria; aerobic; contract rapidly; fatigue-but don't tire to fast; found in legs
Term
Smooth muscle
Definition
no sarcomere units; no troponin and no tropomyosin; Ca^2+ doesn't cause a physical change, causes a chemical reaction that cause phosphorylation of myosin, so myosin can bind to actin and work
Term
Multi-unit smooth muscle
Definition
neurogenic; functions like skeletal muscle, but innervated by autonomic neurons; Ex) eye muscles, large airways in lungs, large blood vessels, arrestor pili
Term
Single-unit smooth muscle
Definition
functional syncytium-cells which work as a unit mechanically and electrically; Ex) uterus during labor, digestive, reproductive, and urinary tracts, small blood vessels; heart has two
Term
Heart-general anatomy
Definition
Left and Right atria; Left and Right ventricles (left has thicker myocardium); Interatrial septum; Interventricular septum; Tricuspid valve; Bicuspid valve
Term
The heart has two separate pumps
Definition
which pump equal amounts of blood simultaneously
Term
Pulmonary system
Definition
low pressure system; receives and pumps blood low in oxygen
Term
Systemic system
Definition
high pressure system; left heart-receives and pumps blood high in oxygen
Term
Functional syncytium
Definition
cells electrically/mechanically connected; work as a unit
Term
Two functional syncytium
Definition
Atrial unit and Ventricular unit
Term
Be able to follow a drop of blood through one full circuit through the body.
Definition
Superior/Inferior Vena Cava, Right atrium, Tricuspid Valve, Right ventricle, Pulmonary Semilunar Valves, Pulmonary Arteries, Lungs, Pulmonary Veins, Left Atrium, Bicuspid Valve, Left Ventricle, Aortic Semilunar Valves, Aorta, Arteries, Arterioles, Capillaries, Venules, Veins
Term
Special adaptation for cardiac tissue
Definition
Intercalated discs-Desmosomes (rives cells together, makes them strong and stretchy) Gap Junctions (allow rapid movement of ions through the cardiac tissue)
Term
What is the purpose of the fibrous skeleton on the heart?
Definition
Stops the conduction of electricity from the atrial tissue directly into the ventricular tissue.
Term
Myocardium
Definition
muscular layer of the heart wall; 99% contractile; 1% auto rhythmic-generate AP all on their own
Term
SA Node
Definition
In the upper wall of the right atrium, close to the superior vena cava; 70-80 times per minute
Term
AV Node
Definition
In the lower interatrial septum; 40-60 times per minute
Term
Bundle of His
Definition
In the upper inter ventricular septum; 15-40 times per minute
Term
Bundle branches
Definition
Extend through the inter ventricular septum
Term
Purkinje fibers
Definition
Extends into the walls of the myocardium of the ventricles
Term
Ectopic foci
Definition
abnormal rate set-purkinje fibers firing 120x's/min.
Term
Why does there have to be an AV nodal delay?
Definition
Atrial chambers need to contract, emptying into the ventricles
Term
Which site is in control in a normal healthy heart?
Definition
SA node
Term
AP in contractile cardiac muscle cells
Definition
RMP, Rapid depolarization-rapid v.gated Na+ channels open, influx, Long Plateau at Peak Potential-v.gated Na+channels close, Ca^2+ influx, Repolarization-Ca^2+ colse, K+ open/afflux
Term
What causes the plateau during an AP in contractile cardiac muscle?
Definition
Refractory Period-prevents initiation of a second AP until resting potential is resored
Term
Why is tetanus impossible in the heart?
Definition
No temporal summation
Term
First sequence in the Cardiac Cycle
Definition
Blood continuously flows into both atria
Term
Second sequence in the Cardiac Cycle
Definition
The pressure of incoming blood opens the right and left AV valves
Term
Third sequence in the CC
Definition
Two thirds of the atrial blood flows passively into the ventricles
Term
Fourth sequence in the CC
Definition
The atria contract to pump the remaining blood into the ventricles
Term
Fifth sequence in the CC
Definition
The atria relax, and the ventricles begin to contract
Term
Sixth sequence in the CC
Definition
The right and left AV valve are closed, and the aortic and pulmonary semilunar valves are opened
Term
Seventh sequence in the CC
Definition
Ventricular contraction pumps blood into the arteries
Term
Eighth sequence in the CC
Definition
The ventricles relax, and the semilunar valves are closed
Term
Electrocardiogram (ECG/EKG)
Definition
records spread of electrical activity through the heart as it is depolarized and repolarized
Term
P wave
Definition
atrial depolarization
Term
PR interval
Definition
internodal delay; atria emptying
Term
QRS complex
Definition
ventricular depolarization; atrial repolarization
Term
ST segment
Definition
ventricles emptying
Term
T wave
Definition
ventricular repolarization
Term
TP interval
Definition
atrials/ventricles filling
Term
Tachycardia
Definition
rate over 100 beats/min. in resting state
Term
Bradycardia
Definition
less than 60 beats/min. in resting state
Term
Heart murmurs
Definition
turbulent flow at abnormal times in the cardiac cycle
Term
Build a muscle fiber
Definition
Myofibril, Mitochondria, Cytosol, Triad, T-tubule (cont. of sarcolemma deep into the cell), Terminal Cisternae, Sarcoplasmic reticulum (organelle wraps around myofibrils), Nucleus, Sarcolemma (cell membrane), Muscle cell (fibers)
Term
Steps required to make a muscle contraction-sliding filament theory
Definition
1) Na+ enters the muscle fiber causing depolarization
2) Wave of depolarization is transmitted into the interior of the fiber by T-tubules
3) Results in the release of calcium ions from the SR
4) Ca^2+ binds to troponin in thin filament
5) Causes tropomyosin to shift and expose active sites on the actin
6) Exposed active sites can now bind w/ myosin heads
7) ATP binds to the myosin head causing head to cock
8) Cross bridge forms btw. actin and myosin
9) Myosin head pushed the actin toward the center of the sarcomere
10) Thin filament slides over the thick filament
11) Another ATP molecule binds to the myosin head and results in the release of the cross bridge
*Cont. as long as there is Nervous stimulation*
Term
Classes of neurons
Definition
Sensory neurons, Interneurons, Motor neurons
Term
Interneurons
Definition
Neurons w/in the CNS that do not extend into the peripheral nervous system. Interposed btw. sensory (afferent) and motor (efferent) neurons
Term
Motor neuron
Definition
efferent neuron that conducts action potentials away from the CNS to effector organs (muscles/glands). Forms the ventral roots of spinal nerves
Term
Sensory neuron
Definition
afferent neuron that conducts impulses from peripheral sensory organs into the CNS
Term
Phantom Pain
Definition
itching, tingling, numbness, pain
Term
Efferent output
Definition
response; autonomic (sympathetic/parasympathetic)
Term
Cholinergic fibers
Definition
receptor/neuron that binds/secrets ACh
Term
Adrenergic fibers
Definition
binds/secretes Epinephrin or Norepinephrine; act via G-proteins
Term
Alpha
Definition
excitatory; vasoconstriction of blood cells
Term
Beta 1
Definition
only found on the heart/kidney; excitatory; increase rate/force of contraction of heart
Term
Beta 2
Definition
inhibitory; Bronchioles, Intestines; dilates airways of lungs
Term
Role of the adrenal gland (medulla) in the sympathetic division
Definition
control of the cardiovascular, respiratory, digestive, urinary, reproductive systems, etc.
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