Term
| what is the class II drug? |
|
Definition
|
|
Term
| what are the effects of esmolol- 3 |
|
Definition
decrease heart rate
decrease action potenial in the SA
decrase conduction in the AV node |
|
|
Term
| which drug has a recovery time of 15 min once terminated |
|
Definition
|
|
Term
| what type of elmination does esmolol have |
|
Definition
|
|
Term
| what patients should you caution the use of esmolol in? -3 |
|
Definition
diabetes
HF
bronchospasm disease |
|
|
Term
| contrainidcaiton for the use of esmolol-3 |
|
Definition
AV block 2n3 3rd degree
severe HF
cardio shock |
|
|
Term
| what are the class three drugs |
|
Definition
amiodarone
dronedarone
dofetilide
Sotalol
Ibutilidie |
|
|
Term
what is main target for amiodarone?
what else does it block?-3 |
|
Definition
K channel
Na, Ca, and adrenergic |
|
|
Term
| what drug prolongs PR, QT, and QRS |
|
Definition
|
|
Term
| what are the 4 effects of amiodarone |
|
Definition
prolong action potential
prolong refractory
inhibit cell coupling
inhibit abnormal automaticity |
|
|
Term
| which drug has a structure like thyroid hormone |
|
Definition
|
|
Term
amiodarone is highly lipophobic/philic?
what does this do- |
|
Definition
philic
eliminated very slowly! |
|
|
Term
| how is amiodarone elminated |
|
Definition
|
|
Term
| what are some severe ADEs of amiodarone-3 |
|
Definition
pulmonary fibrosis
deposits on cornea
QT prolongation |
|
|
Term
| caution the use of amiodarone in what patients-3 |
|
Definition
prexisitng QT prolong
respiratory distress
optic neuropathy |
|
|
Term
| contrinidcations for amiodarone -3 |
|
Definition
SA dysfunction
2nd-3rd degree AV block
syncope |
|
|
Term
| how does dronedarone differ from amiodarone-2 |
|
Definition
less lipophillic
less thyroid like |
|
|
Term
| main ADEs of dronedarone-3 |
|
Definition
QT prolongation
asthenic (loss of energy)
skin(dermiitis) |
|
|
Term
| caution use of dronedarone in-4 |
|
Definition
HF
hepatic impariment
electrolyte imabalnce
igh digoxin |
|
|
Term
| which drug increase mortality in ppl with permanent atrial fibrilation |
|
Definition
|
|
Term
| which drug is the pure blocker of K channels? |
|
Definition
|
|
Term
| what are the effects of dofetilide-2 |
|
Definition
| prolonged refractory and action potentialo in atria and ventricles |
|
|
Term
| which class III drug prolongs QT, but not PR or QRS |
|
Definition
|
|
Term
which class III drugs are proarrythmic?-3
-what are they espeically prone to? |
|
Definition
dofetilide & sotolol & ibutilide
torsaeds de pointes |
|
|
Term
| what is the normal range for potassium |
|
Definition
|
|
Term
what drugs do you caution the use with dofetilide-2
what drugs are contraindicated- 5 |
|
Definition
k depleting diuretics
drugs that prolong QT;
verapamil, cimetadine, trimethorpim, ketoconazole, HCTZ |
|
|
Term
| which drugs must be started under close ECG monitoring-3 |
|
Definition
dofetilide
sotalol
ibutilide |
|
|
Term
which Class III agent also blocks B1 and B2 receptors?t
at what dose does it start doing it at?
what dose does it start doing the K at |
|
Definition
|
|
Term
| caution use of sotalol in what patients-4 |
|
Definition
renal impaired
HF
hypokalemia
hypomagnesium |
|
|
Term
| sotalol is contraindicated if potassium concentration is below what? |
|
Definition
|
|
Term
| which class III drug inhibits potassium and also maybe Na |
|
Definition
|
|
Term
| what is the only contraindication for ibutilide |
|
Definition
|
|
Term
| what are the class 4 agents-2 |
|
Definition
|
|
Term
| what factors do warfarin inhibit |
|
Definition
| 2 (prothrombin),7a, 9, 10 |
|
|
Term
| what does rivaroxaban inhibit |
|
Definition
|
|
Term
| what does dabigatran inhibit |
|
Definition
| direct inhibitor of thrombin (IIa) |
|
|
Term
rivaroxiban vs dabigatran:
elimination:
dose adjustments on Cr CL:
drug interactions: |
|
Definition
R= liver, D- renal
if less than 50 for R, <30 for D
R= 3A4; D= PgP |
|
|
Term
| what is the antidote for bleeding for rivaroxiban and dabigatran? |
|
Definition
|
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