Term
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Definition
-Stabilizing scaffold
-influences survival, development, proliferation, migration, function |
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Term
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Definition
fibroblasts
osteoblasts
chondrocytes |
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Term
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Definition
Gly-X-Y
X: proline
Y: hydroxyproline/hydroxylysine
left handed helix, 3 AAs/turn
Glycine in interior |
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Term
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Definition
-Fibril forming, interstitial (I, II, III, V, XI)
-FACIT (IX, XII, XIV)
-Network forming (IV)
-Anchoring filaments (VII) |
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Term
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Definition
Type I: bone, tendon, dermis, cornea, dentin. Osteogenesis imperfecta
Type II: cartilage, vitreous humor. Stickler syndrome
Type III: reticular fibers of most tissues (lung, liver, dermis, vessel walls). Vascular E-D Syndrome
Type V: dermis, interstitial tissues. Classical E-D syndrome |
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Term
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Definition
1. pro-alpha chain synthesis
2. hydroxylation of prolines and lysines (prolyl hydroxylase requires vitamin C)
3. glycosylation of hydroxylysines
4. self-assembly of pro-alpha chains
5. procollagen triple-helix formation
6. secretion
7. cleavage of propeptides (procollagen --> tropocollagen) (procollagen N-proteinase and procollagen C-proteinase)
8. self-assembly into fibril (driven by insolubility of tropocollagen)
9. aggregation of collagen fibrils to form a collagen fiber |
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Term
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Definition
1. lysyl oxidase (Cu requiring enzyme): acts on lysines and hydroxylysines, forms covalent bonds
2. most form in non-helical segments
3. can be intramolecular/intermolecular |
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Term
| FACIT Collagens IX, XII, XIV |
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Definition
Fibril associated collagens with interrupted triple helices
-link fibrils to one another and other ECM macromolecules
-globular N-terminus of IX binds to proteoglycans in ECM
-helical domains interact w collagen type II (esp. important in cartilage) |
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Term
| Network Forming Collagen (IV) |
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Definition
-Major type in basal lamina
-flexible structure: interrupted triple helix, flexible sheet-like multilayered network |
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