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Fat Soluble Vitamins
Fat Soluble Vitamins
16
Medical
Undergraduate 2
04/12/2012

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Cards

Term
Synthesis & storage of vitamin A
Definition
β-carotene is ingested and absorbed in the intestine & converted to Vit. A in the mucosa. 90% is stored in the liver as retinal palmitate & carotenoids are stored in adipose.
Term
Food sources vitamin A
Definition
Liver, milk, alfalfa & green leafy vegetables.
Term
RDI Vitamin A
Definition
0.7mg (expressed in retinol equivalents: 1RE= 1mcg retinol = 6mcg β-carotene = 12mcg other carotenes)
Term
Function of vitamin A
Definition
+ Part of opsin in rod cells that function for photo reception
+ Synthesis of some glycoproteins in mucous
+ Controls cell growth in cell differentiation
+ Carotenoids are antioxidants
Term
Vitamin A deficiency
Definition
+ Night blindness + Xerophthalmia (dry eyes)
+ Skin disorders
+ Lack of growth
Term
Vitamin A toxicity
Definition
+ Occurs over 200mg in adults (from eating polar bear, seal liver or too many multivitamins)
+ Causes headache, nausea, vomiting, increased cerebrospinal fluid pressure, blurred vision
Term
Functions of vitamin D
Definition
+ Calcium homeostasis: regulates calcium absorption (bone growth)
+ Cellular differentiation
Term
Sources of vitamin D
Definition
+ Body can synthesise from 7-OH Cholesterol in skin if there's sufficient sunlight
+ Also found in oily fish, egg yolk, butter and liver
Term
RDI vitamin D
Definition
20ug in adults
Term
Vitamin D deficiency
Definition
+ In kids: Rickets or osteomalacia (bowed bones)
+ In adults: Osteoporosis
Term
Vitamin D toxicity
Definition
+ Hypervitaminosis D
+ Toxic dose is only 10x higher than normal dose
+ Causes hypercalcaemia: Anorexia, nausea, vomiting, renal failure
Term
Functions of vitamin E
Definition
+ Antioxidant (protects cells, lungs and DNA from damage)
+ Blood clotting: required as cofactor for clotting factors 2, 7, 9 and 10
+ Bone formation
Term
Food sources of vitamin E
Definition
+ Green leafy vegetables, plant oils, meat, eggs
+ Bacteria in large intestine
Term
RDI vitamin E
Definition
5mg/day
Term
Vitamin E deficiency
Definition
Very rare unless one has difficulty absorbing fats
+ Haemolytic anaemia/ generalised bleeding
+ spinocerebellar signs
Term
Function of vitamin K
Definition
+ Blood coagulation
+ Bone metabolism
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