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Final Test Key Terms
Module VI, Unit A &B; Module V, Unit A, B, & C
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Undergraduate 1
05/05/2009

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Term
anabolism
Definition
the set of metabolic pathways that construct molecules from smaller units
Term
bile
Definition
a digestive juice secreted by the liver and stored in the gallbladder
Term
bilirubin
Definition
bile pigment that is product of the breakdown of the heme portion of hemoglobin
Term
calculi
Definition
abnormal stones formed in body tissues by an accumulation of mineral salts
Term
catabolism
Definition
set of metabolic pathways which break down molecules into smaller units and release energy
Term
cholecystitis
Definition
inflammation of the gallbladder
Term
cholelithiasis
Definition
stone in the gallbladder
Term
conjugated bilirubin
Definition
bilirubin attached to another molecule
Term
diabetes mellitus
Definition

multisystem disease related to abnormal insulin production, impaired insulin utilization, or both

Term
diabetic ketoacidosis
Definition
an acute metabolic complication of diabetes occurring when fats are metabolized in the absence of insulin resulting in the formation of acid byproducts, such as ketones
Term
endocrine
Definition
gland which secretes hormones directly into the blood stream
Term
exocrine
Definition
a gland that secretes externally through a duct
Term
glycogen
Definition
form in which carbohydrates are stored in the body
Term
glycogenesis
Definition
the formation of glycogen from glucose
Term
glycogenolysis
Definition
metabolic process by which glycogen is broken down
Term
glycosuria
Definition
sugar in the urine
Term
hyperglycemia
Definition
high blood glucose levels
Term
hyperglycemic hypersmolar nonketonic syndrome
Definition

a life threatening syndrome that can occur in the patient with diabetes who is able to produce enough insulin to prevent diabetic ketoaacidosis but not enough to prevent sever hyperglycemia, osmotic diuresis, and extracellular fluid depletion

Term
hypoglycemia
Definition
low blood glucose levels
Term
Addison’s Disease
Definition
endocrine disorder where there is adrenocortical insuffiency (hypofunction of the adrenal cortex) usually caused by an autoimmune response
Term

Addisonian Crisis

Definition
symptoms of Addison’s disease usually first appear during an Addisonian crisis which is a life threatening emergency caused by acute or sudden adrenal insufficiency. It is triggered by stress, or sudden withdrawal of corticosteroid replacement therapy. Symptoms include hypotension, tachycardia, dehydration, hyponatremia, hyperkalemia, hypoglycemia, fever, weakness and confusion
Term
Adrenal insufficiency
Definition
hypofunction of the adrenal cortex, ie. the adrenal gland stops making all or some of the adrenal corticosteroids (glucocorticosteroids, mineralcorticosteroids and androgens)
Term
Androgens
Definition
class of steroids synthesized by the adrenal gland which stimulate pubic and axillary hair growth and sex drive in females. Androgens are converted into estrogen in women
Term
Chvostek’s sign
Definition
When the facial nerve is tapped at the angle of the jaw (i.e. masseter muscle), the facial muscles on the same side of the face will contract momentarily (typically a twitch of the nose or lips) because of hypocalcaemia (ie from hypothyroidism) with resultant hyperexcitability of nerves
Term
Cretinism
Definition
severely stunted physical and mental growth due to untreated congenitaldeficiency of thyroid hormones (hypothyroidism) or from prolonged nutritional deficiency of iodine
Term
Cushing’s syndrome
Definition
(also called hyperadrenocorticism or hypercorticism) is a hormone (endocrine) disorder caused by high levels of cortisol (hypercortisolism) in the blood.  Signs and symptoms include rapid weight gain of the abdomen and face, fat pads along the collar bone, excessive sweating, thinning of the skin, stretch marks, insomnia, depression and anxiety
Term
Euthyroid
Definition
the state of having normal thyroid gland function
Term
Exophthalmos
Definition
marked protrusion of the eyeballs which is a symptom of Grave’s disease (hypothyroidism)
Term
Glucocortcoids
Definition
steroid hormone secreted by the adrenal gland and increases gluconeogenesis. They promote release of amino acids in the muscles and exert an anti-inflammatory effect of the body
Term
Goiter
Definition
generalized enlargement of the thyroid gland indicating hyper or hypo thyroidism
Term
Hyperaldosteronism
Definition
excessive aldosterone secretion which effects sodium retention and potassium secretion causing hypertension and hypokalemic acidosis
Term
Hyperplasia
Definition
an increased number of cells of a body part that results from an increased rate of cell division
Term
Arthritis
Definition
inflammation of a joint; most prevalent types are osteoarthritis, rheumatoid arthritis, and gout
Term
Arthrogram
Definition
a radiographic record after introduction of opaque contrast material into a joint
Term
Arthroplasty
Definition
surgical reconstruction or replacement of a joint
Term
Arthrotomy
Definition
incision into a joint
Term
Crepitus
Definition
a clicking sound often heard in movement of joints, for example, in temporomandibular joint resulting from joint irregularities
Term
Cutaneous nodules
Definition
small, pendulous outgrowth of the skin
Term
Gout
Definition
recurrent attacks of acute arthritis associated with increased levels of serum uric acid
Term
Hyperuricemia
Definition
abnormally high levels of uric acid in the blood
Term
Osteoarthritis
Definition
a slowly progressive non-inflammatory disorder of the diarthrodial (synovial) joints
Term
Pannus formation
Definition
formation of excessive folds of inflamed tissue on a joint affected by rheumatoid arthritis
Term
Rheumatoid arthritis
Definition
a chronic, systemic autoimmune disease characterized by inflammation of connective tissue in the diarthrodial (synovial) joints, typically with periods of remission and exacerbation
Term
Subluxation
Definition
a partial or incomplete displacement of the joint surface
Term
Synovitis
Definition
inflammatory condition of the synovial membrane of a joint as a result of an aseptic wound or a traumatic injury such as a sprain or severe strain
Term
Synovectomy
Definition
surgical removal of synovial membrane
Term
Tophi
Definition
visible deposits of sodium urate crystals; seen in chronic gout
Term
Vasculitis
Definition
inflammation of the blood vessels; it may be caused by a systemic disease or an allergic reaction
Term
AKA
Definition
 Above the Knee Amputation
Term
BKA
Definition
Below the Knee Amputation
Term
Barlow maneuver
Definition
A physical examination performed on infants to
screen for developmental dysplasia of the hip
Term
Calcaneus
Definition
The calcaneus is the bone in the back of the foot,
commonly referred to as the heel bone.  This bone helps support the foot and is important in normal walking motions.
Term
Dislocation
Definition
Or luxation occurs when bones in a joint become
displaced or misaligned.  Often caused by sudden impact to the joint
Term
Dorsal kyphosis
Definition
Abnormal condition of the vertebral column,
characterized by increased convexity in the curvature of the thoracic
spine as viewed from the side.  Also called humpback, roundback.
Term
Equino Varus
Definition
Also known as clubfoot…a foot deformity in which the
heel is turned inward and the foot is plantar flexed
Term
Gangrene
Definition
A complication of necrosis characterized by the decay of body tissues, which become black (and/or green) and malodorous.  It is caused by infection or ischemia.
Term
Lordosis
Definition
“swayback”, a medical term used to described an inward curvature of a portion of the vertebral column.
Term

Ortolani Maneuver
Definition
A physical examination for developmental dysplasia
of the hip.  It is performed by gently abducting the infants leg using the examiners thumb while placing anterior pressure on the greater trochanter using the examiners index and forefinger.
Term
Pavlik harness
Definition
Used in the treatment of hip dysplasia in infants.
The pavlik harness is fit to the baby and holds the baby hips in proper position
Term
Prosthesis
Definition
Artificial substitute for a missing part of the body.
Term
Scoliosis
Definition
Medical condition in which a person’s spine is curved from side to side, shaped like an “s”, and may also be rotated.  Can be very painful.
Term
Spica Cast
Definition
Also called body cast, immobilizes the hips and thighs so that bones or tendons can heal properly. It’s usually put on in surgery while the child is sleeping. Put on child to keep their hips and legs from moving.
Term
Talipes
Definition
A congenital deformity that develops in the womb during the
first trimester (btwn 8 to 12 weeks)  and causes an abnormal twisting of the ankles, heels, toes and feet.  Talipes is present in one of ever 1,000 childbirths in the US, and 95% of these incidences are known as congenital talipes equinovarus or CLUBFOOT.
Term
Valgus
Definition
Abnormal outward turning of a bone, especially of the hip, knee, or foot. “knock-kneed"
Term
Varus
Definition
Abnormal inward turning of a bone, especially of the hip, knee or foot
Term
Hyperthyroidism
Definition
a clinical syndrome where there is a sustained increase in synthesis and release of thyroid hormones by the thyroid gland
Term
Hypothyroidism
Definition
insufficient circulation of thyroid hormones resulting in a hypometabolic state
Term
Isotope
Definition
one of two or more forms of a chemical element having the same number of protons in the atomic nucleus but different number of neutrons and thus a different atomic mass; many isotopes are used in diagnostic and therapeutic procedures
Term
Metabolic rate
Definition
the amount of energy liberated or expended in a given unit of time
Term
Mineralocorticoids
Definition
a hormone secreted by the adrenal cortex that maintains normal blood volume, promotes sodium and water retention and increases urinary excretion of potassium and hydrogen ions; aldosterone is the most potent; trauma and stress increase secretion
Term
Myxedema
Definition
the progression of the mental sluggishness, drowsiness and lethargy of hypothyroidism to a notable impairment of consciousness or coma that is a medical emergency
Term
Pheochromocytoma
Definition
a rare condition characterized by a tumor of the adrenal medulla that produces excessive catecholamines causing persistent or intermittent hypertension
Term
Striae
Definition
a streak or linear scar that often results from rapidly developing tension in the skin; purplish striae are among the classic findings in hyperadrenocorticism
Term
Tetany
Definition
increased nerve excitability and sustained muscle contraction that results from low calcium levels that allow sodium to move into excitable cells, increasing depolarization
Term
Thyrotoxic crisis
Definition
an acute, rare condition in which all hyperthyroid manifestations are heightened
Term
Thyrotoxicosis
Definition
a hypermetabolic state caused by excessive circulating levels of T4, T3 or both
Term
Trousseau’s sign
Definition
a test for latent tetany in which carpal spasm is induced by inflating a BP cuff on the upper arm to a pressure exceeding systolic BP for 3 minutes; a positive test may be seen in hypocalcemia and hypomagnesemia
Term

 

Truncal Obesity

Definition
obesity that preferentially affects or is located in the trunk of the body as opposed to the extremities
Term
Aseptic necrosis
Definition
Condition in which poor blood supply to an area of bone leads to bone death. Also called avascular necrosis and osteonecrosis
Term
Atony
Definition
lacking normal tone, as in the case of a muscle that is flaccid
Term
Avascular necrosis
Definition
the consequence of temporary or permanent cessation of blood flow to the bones. The absence of blood causes the bone tissue to die, resulting in fracture or collapse of the entire bone
Term
Callus
Definition
The hard bony tissue that develops around the ends of a fractured bone during healing
Term
Cast Syndrome
Definition
Condition occurs if the body cast is applied too tightly and the cast compresses the superior mesenteric artery against the duodenum.  The patient generally complains of abdominal pain, abdominal pressure, nausea and vomiting.
Term
Catabolism
Definition
a metabolic process in which complex molecules are broken down into simple ones with the release of energy
Term
Compartment syndrome
Definition
a pathologic condition caused by progressive development of arterial compression and consequent reduction of blood supply.  The compression may result from an overly restrictive dressing or cast or from nonexpansive muscle fascia.  Clinical manifestations include swelling, restriction of movement, brown urine, myoglobinuria, vascular compromise, and severe pain or lack of sensation.  It can result in a permanent contracture deformity of the hand or foot, with or without a fracture.  In severe cases, it can lead to necrosis and necessitate the amputation of an extremity.  Treatment includes elevation, removal of restrictive dressings or casts, and potentially a surgical decompression
Term
Contracture
Definition
an abnormal, usually permanent condition of a joint, characterized by flexion and fixation.  It may be caused by atrophy and shortening of muscle fibers resulting from immobilization or by loss of the normal elasticity of connective tissues or the skin, such as from the formation of extensive scar tissue over a joint.
Term
external fixation
Definition
metallic device composed of metal pins that are inserted into the bone & attached to external rods to stabilize the fracture while it heals
Term
fascia
Definition
layers of connective tissue w/ intermeshed fibers that can withstand limited stretching
Term
fatigue/stress fracture
Definition
fracture that occurs in normal or abnormal bone that is subject to repeated stress, such as from jogging or running
Term
internal fixation
Definition
devices including pins, plates, intramedullary rods & metal & bioabsorbable screws are surgically inserted at the time of realignment
Term
intertrochanteric fracture
Definition
a crack in the proximal femur between the greater & the lesser trochanters that usually requires surgical intervention
Term
osteoblasts
Definition
synthesized organic bone matrix (collagen) & are the basic bone-forming cells
Term
osteomyelitis
Definition
severe infection of the bone, bone marrow & surrounding soft tissue
Term
osteoporosis
Definition
chronic, progressive metabolic bone disease characterized by low bone mass & structural deterioration of bone tissue, leading to increased bone fragility
Term
paresthesias
Definition
numbness & tingling, often described as “pins & needles” sensation
Term
petechiae
Definition
pinpoint-sized red dots under the surface of the skin
Term
sprain
Definition
an injury to tendinoligamentous structures surrounding a joint, usually caused by a wrenching or twisting motion
Term
strain
Definition
excessive stretching of a muscle & its fascial sheath (often involves tendon)
Term
tonus
Definition
the elastic tension of living muscles, arteries, etc. that facilitate response to stimuli
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