Term
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Definition
| Rifampin, Red secretions, Revs up p450, Rifampin |
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Term
| rRNA syn & mRNA, tRNA syn |
|
Definition
rRNA- Nucleolous
tRNA & mRNA - nucleoplasm |
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Term
|
Definition
|
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Term
| a-Amantinin (mushroom poison) affects Eukaryotic DNA syn? |
|
Definition
| inhibits RNA-polymerase 2 in eukaryotes --> liver damage |
|
|
Term
| Amino-acyl tRNA synthetase |
|
Definition
| adds an AA to tRNA at 3' end |
|
|
Term
| translocation of tRNA requires what EF? |
|
Definition
Prokaryote: EF-G
Eukaryote: EF-2 |
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Term
| What antibiotics attack 50S ribosome |
|
Definition
| Streptogramin, Clindamycin, Chloramphenicol, Macrolides, Linezolid |
|
|
Term
| What antibiotics attack 30S? |
|
Definition
Tetracycline & Aminoglycosides
*aminoglycosides do not work on anaerobes, bc aminoglycosides require O2 in order to work |
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Term
|
Definition
|
|
Term
| What AA are modified by Golgi? |
|
Definition
Golgi Sat on THREe ASPs
Serine, Threonine, Asparagine |
|
|
Term
| Glycolysis Rate limiting enzyme |
|
Definition
Phosphofructokinase1
Fructose-6-P --> Fructose-1,6-biphosphate |
|
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Term
| rxn that connects glycolysis & gluconeogenesis |
|
Definition
enzyme: pyruvate kinase
PEP (phosphoenol pyruvate) --> pyruvate |
|
|
Term
| Gluconeogenesis rate limiting enzyme |
|
Definition
Fructose-1,6-biphosphatase
Fructose-1,6-biphosphate --> Fructose-6-P |
|
|
Term
What enzynes are responsible for increasing intracellular levels of Fructos-2,6-bisphosphate
|
|
Definition
| Phosphofructokiase-2 (PFK-2) increases levels of fru-2,6-bisphosphate |
|
|
Term
|
Definition
MOA: inhibts ribonucleotide reductase
Not able to syn pyrimidines
use for sickle cell and cancer |
|
|
Term
|
Definition
| inhibits bacterial dihydrofolate |
|
|
Term
| Adenosine deaminase deficiency |
|
Definition
Execss ATP & dATP --> neg feedback --> prevents DNA syn --> Dec lymphocyte ct
Major cause of Severe combined immunodeficiency disease (SCID)
(bubble boy) |
|
|
Term
|
Definition
defective PURINE salvage bc no HGPRT; excess uric acid & excess purine production
Sx: Gout, mental retardation, lipbiting (self-mutilation)
tx: allopurinol |
|
|
Term
|
Definition
| Sx: severe recurrent infections; chronic diarrhea; failure to thrive; absence of thymic shadow on CXR |
|
|
Term
|
Definition
topoisomerase Ab
Diffuse scleroderma |
|
|
Term
|
Definition
|
|
Term
|
Definition
bind 30S subunit- prevent attachment of aminoacyl-tRNA
so not able to charge with tRNA with an AA |
|
|
Term
|
Definition
Phosphotransferase deficiency
cannot put Mannose-6-P on proteins; so these proteins are sent out of the cell instead of going to lysosomes |
|
|
Term
|
Definition
Type 1 collagen defect
blue sclera
many fractures with minor trauma |
|
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Term
|
Definition
Type 3 collagen defect
aneurysms |
|
|
Term
|
Definition
type 4 collagen defect; X-liked recessive
Alport cant see, cant pee, cant hear |
|
|
Term
|
Definition
defect in elastin fibrillin
medial cystic artery aneuyrsm |
|
|
Term
| a1-anti-trypsin deficiency |
|
Definition
Emphysema & cirrhosis
a1-antitrypsin inhibits elastase. so if you don't have a1, then you will have unopposed elastase activity
Young ppl, non-smoker --> Panacinar Emphysema |
|
|
Term
| X-linked recessive disorders |
|
Definition
Be Wise Fools GOLD Heeds Silly Hope
Bruton's agammaglobulinemia, Wiskott-Aldrich syndrome, FAbry's disease, G6PD deficiency, Ocular albinism, Lesch Nyhan syndrome Duchene's (Beckers) MD, Hunter's syndrome, Hemophilia A & B |
|
|
Term
ATP + Methionine --> SAM
S-adenosyl methionine
SAM transfers METHYL units |
|
Definition
| Vitamins B12 & Folate are necessary to regenerate SAM & Methionine |
|
|
Term
Malnutrition
Kwashiorkor & Marasmus |
|
Definition
Kwashiorkor- total protein deficiency- skin lesions, skin & hair depigmentation, edema, fatty liver
No ApoB100
Marasmus- TOTAL calorie deficiency - tissue & muscle wasting |
|
|
Term
| Rate Limiting Enzyme: Glycolysis |
|
Definition
| Phosphofructokinase-1 (PFK-1) |
|
|
Term
| Rate Limiting Enzyme: Gluconeogenesis |
|
Definition
| Fructose-1,6-bisphosphatase |
|
|
Term
| Rate Limiting Enzyme: TCA cycle |
|
Definition
|
|
Term
| Rate Limiting Enzyme: Glycogen synthesis |
|
Definition
|
|
Term
| Rate Limiting Enzyme: GLycogenolysis |
|
Definition
|
|
Term
| Rate Limiting Enzyme: HMP shunt |
|
Definition
| GLucose-6-phosphate dehydrogenase (g6pd) |
|
|
Term
| Rate Limiting Enzyme: De novo pyrimidine synthesis |
|
Definition
| Carbamoyl phosphate synthetase 2 |
|
|
Term
| Rate Limiting Enzyme: De novo purine synthesis |
|
Definition
| GLutamine-PRPP amidotransferase |
|
|
Term
| Rate Limiting Enzyme: Urea cycle |
|
Definition
| Carbamoyl phosphate synthetase 1 |
|
|
Term
|
Definition
| Acetyl-CoA carboxylase (ACC) |
|
|
Term
| Rate Limiting Enzyme: Fatty Acid Oxidation |
|
Definition
| Carnithine acyltransferase 1 |
|
|
Term
| Rate Limiting Enzyme: Ketogenesis |
|
Definition
|
|
Term
| Rate Limiting Enzyme: Cholesterol synthesis |
|
Definition
|
|
Term
Niacin deficiency = Pellagra
Tryptophan is used to syn --> Niacin |
|
Definition
B3 = Niacin
D3 = Niacin deficiency = Pellagra
Dementia, Diarrhea, Dermatitis |
|
|
Term
| Pantothenic Acid = Coenzyme A |
|
Definition
| TCA cycle: CoA+Oxaloacetate --> Citrate+CoA --> Succinyl-CoA |
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