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First Week 2
First Week of Humand Development 2
33
Science
Undergraduate 4
01/16/2009

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Term
Cleavage of Zygote
Definition
consists of repeated mitotic divisions of zygote, resulting in rapid increase in number of cells.
Term
Blastomeres
Definition
30 hrs. after fertilization. After 9-cell stage blastomeres change shape and tightly align themselves against each other to form compact ball. then forms internal(embroblast) of blastocyst.
Term
Morula
Definition
12 blastomeres form morula
Term
Blastogenesis
Definition
shortly after morula a fluid-filled space called blastocyst cavity and outer cell layer called trophoblast give rise to embryonic part of placenta.
Term
Trophoblast at implantation
Definition
At implantation the trophoblast starts to proliferate rapidly and differentiates into two layers: cytotrophoblast, and the syncytiotrophoblast
Term
Zona Pellucida Degeneration
Definition
occurs 4 days after conception and must do so for implantation to occur
Term
Hypoblast
Definition
7 days after implantation, this layer of cells appears on the surface of inner cell mass facing the blastocyst cavity. Future Endoderm
Term
Layers of Embryoblast
Definition
Epiblast, hypoblast
Term
Layers of trophoblast
Definition
cytotrophoblast (inner layer), Syncytiotrophoblast (outer layer)
Term
Pre-Testicular Causes of Infertility
Definition
Isolated gonadotropin deficiency(Kallmann's syndrome), pituiatry insufficiency(tumors, infiltrative processes, operation, radiation), hyperprolactinemia, hemochromatosis, exogenous hormones
Term
Testicular Causes of Infertility
Definition
chromosomal abnormalities(Klinefelter's syndrome, XXY syndrome), myotonic dystrophy, sertolil-cell-only syndrome(germinal cell aplasia), gonadotoxins(drugs, radiation), orchitis, trauma-systemic disease(renal failure), defective androgen synthesis or action, cryptorchidism-varicocele.
Term
Noonan's Syndrome
Definition
genetic condition can affect heart, growth, blood clotting, mental and physical development=> behavior problems, learning difficulties. most common condition associated with congenital heart abnormality.
Term
Cryptorchidism
Definition
one or both of testes is missing from scrotum. Failure of testis to descend during fetal development from abdominal position, thorugh inguinal canal, to ipsilateral scrotum.
Term
Ectopic Pregnance
Definition
uterine tubes are site of tubal ectopic pregnancies.
Term
Signs and Symptoms of Ectopic Pregnancy
Definition
missed periods, breast tenderness, nausea, vomitting, frequent urination, vaginal spotting or bleeding, dizziness or fainting, low blood pressure(both caused by blood loss), lower back pain.
Term
Cause of Ectopic Pregnancy
Definition
infection or inflammation of uterine tube may partially or entirely block it. PID (Pelvic Inflammatory Disease).
Term
Pelvic Inflammatory Disease
Definition
chlamydia if left untreated, can lead to Pelvic Inflammatory disease, an infection of the uterus, fallopian tubes, and other reproductive organs.
Term
Symptoms of Pelvic Inflammatory Disease
Definition
pelvic discomfort and vaginal discharge to incompacitating abdominal pain nausea and vomiting. Fever
Term
Pelvic Inflammatory Disease Treatment
Definition
Doxycycline 100mg orally or IV every 12 hours. 14 days.
Term
Ectopic Pregnancy Diagnosis
Definition
blood test measures hCG, produced by placenta. hCG appears in blood 10 days after conception, doubles every 2 days for first 10 weeks.
Term
High Risk of Ectopic Pregnancy
Definition
women between 35 and 44, PID, previous ectopic pregnancy, surgery on fallopian tube, infertility problems or medication to stimulate ovulation.
Term
Ectopic Pregnancy Treatment
Definition
methotrexate, laparoscopy
Term
Mittelschmerz
Definition
normal, and common symptom of painful ovulation or mid-cycle pain which affects 20% of women. rarely serious
Term
Mittelschmerz cause
Definition
Not sure but follicle growth stretches surface of ovary, causing pain. Also might be fluid released from follicle irritates lining of abdomen.
Term
Mittleschmerz signs and symptoms
Definition
one-sided abdominal pain. pain occurs on side ovulating. few minutes to few hours, sharp or dull. rarely sever pain. may be associated with some vaginal bleeding caused by rapid drop in estrogen
Term
Mittleschmerz treatment
Definition
pain reliever, acetaminophen (tylenol, others), aspirin, ibuprofen (advil, motrin, others) or naproxen (aleve).
Term
Anovulatory cycle
Definition
menstrual cycle in which ovulation fails to occur. caused by eating disorder, hpothalamic dysfunction, hyperprolactinemia, polycystic ovary syndrome, luteal phase defects, tumors of pituitary gland, adrenal gland or ovaries, resistant ovary syndrome, automimmune oophoritis, steroidal oral contraceptives
Term
Anovulatroy cycle diagnostic tests
Definition
serum assays, LH, FSH, progesterone, prolactin, testosterone and SHBG, CT scan or MRI scan of pituitary and hypothalamus, ovarian biopsy,
Term
In Vitro Fertilization
Definition
method of assisted reproduction. Sperm & egg combined in lab dish for fertilizatioon. embryo then transferred to woman's uterus to implant and develop. usually 2-4 placed in at a time. each attempt called a cycle.
Term
Miscarriage or sponataneous abortion
Definition
natural or accidental termination of a pregnancy where embryo or fetus is incapable of surviving.
Term
Miscarriage/spontaneous abortion symptoms
Definition
is inevitable with following symptoms: obious rupture of membranes, tissue in cervix, absence of fetal heart at a BHCG level consisten with fetal heart activity.
Term
Miscarriage/Spontaneous Abortion Cause
Definition
abnormal sperm/ovum or combination. physical trauma, exposure to chemicals, infectin, obesity, high caffeine intake >300mg/day, alcohol consumption, use of NSAIDs.
Term
Miscarriage/Spontaneous Abortion Treatment
Definition
dilation and curettage is commonly used and generally fastest way to remuve tissue from the uterus.
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