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FOM
Nerve and Mediastinum
49
Medical
Graduate
06/09/2011

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Term
Afferent
Efferent
Definition
Afferent - towards the brain
Efferent - away from the brain
Term
PAD for the meninges
Definition
P - pia mater
A - arachnoid mater
D - dura mater
Term
what do the meninges provide
Definition
support and protection to the nervous sytem
Term
somites
Definition
mesoderm that will become dermis, muscle and vertebrae
Term
Notochord
Definition
involved in neurulation and induction of the neural form
Term
Anencephaly
Definition
Failure of anterior neuropore closure
(maternal folate deficiency is associated with neural tube defects)
Term
Spina Bifida
Definition
Failure of posterior neuropore closure (maternal folate deficiency is associated with neural tube defects)
Term
Neural crest cells
Definition
derived from ectoderm can differentiate into connective tissues and bones, glial and schwann cells, and melanocytes
Term
pseudo-unipolar neurons
Definition
found in PNS (sensory neurons) also part of the DRG
Term
Neuron cell body
Definition
very large nucleus, Increased levels of ER to produce and secrete proteins, an elaborate Golgi
Term
Intermediate filaments found in neurons
Definition
neurofilament - stabilize and maintain neuron morphology
Term
Microtubules
Definition
run the length of the axon
Kinesin transport towards plus end of microtubule
Term
Shingles (Herpis Zoster)
Definition
same virus that causes chickenpox. After chickenpos, the virus remains dormand in DRG but can become active
Term
Dendritic Spines
Definition
increase the surface are of dendritesand can increase connections between cells (neural plasticity)
Term
Action Potential
Definition
generated at the Axon Hillock, VGNaC open and depolarize the membrane moving the action potential along the axon
Term
Saltatory Conduction
Definition
Action potential jumping from node to node
Term
Synapse
Definition
AaP causes depolarization and opening of Ca2+ channels. Calcium induces vesicle release
Term
Neuroglia
Definition
non-neuronal cells in the CNS and PNS - function is support and structure
Term
Astrocytes
Definition
prominent in CNS, support (skeletal), electrolyte balance (K+), communicate with capillary BBB, and interaction with the immune system along with sequestration of NT
Term
2 types of Astrocytes
Definition
Fibrous - in white matter, fine long processes
Protoplasmic - gray matter, shorter processes
Term
Oligodendrocyte
vs
Schwann
Definition
Oligodendrocyte - CNS form myelin up to fifty enternodes
Schwann cell - PNS myelinate only one internode
Term
Myelin
Definition
increased conduction
Term
Multiple Sclerosis
Definition
autoimmune or viral (women>men) areas of demyelination and T-cell predominant inflammation in white matter
Sudden blindness in one eye
Term
Microglia
Definition
(macrophage) first to respond to brain injury, phagocytosis of debri and immune responses
Term
Ependyma cells
Definition
specialized epithelial cell,, cuboidal (ciliated for CSF movement)
Term
Choroid Plexus
Definition
secrete cerebraspinal fluid
Term
CSF
Definition
70% secretions from the choroid plexus, volume is about 140 ml (CSF is acellular)and drains into the venous system
Term
Peripheral ganglia
Definition
Sensory (DRG) and autonomic
satellite cells support the cell bodies in the PNS
Term
Sympathetic
Definition
thoracolumbar
short-preganglionic, long post-ganglionic
"fight or flight" response
Term
Parasympathetic
Definition
craniosacral
long pre-ganglionic neurons and short post-ganglionic neurons
Term
Parasympathetic
Definition
craniosacral
long pre-ganglionic neurons and short post-ganglionic neurons
Term
Blood supply to the Thymus
Definition
Inferior thyroid and anterior intercostals off the internal thoracic arteries
Term
Thymus
Definition
located in the anterior part of the superior mediastinum, derived from the third pharyngeal pouch
Important role in development of T lymphocytes "production"
venous drainage into the left brachiocephalic vein, internal thoracic veins, and inferior thyroid vein
Term
Thymoma
Definition
tumors of the thymus, can grow and affect the trachea, and SVC
Term
Great veins
Definition
Internal jugular vein (blood from haen & neck)
subclavian vein ( blood from arm)
Brachiocephalic vein (arm and head)
Term
Phrenic Nerve
Definition
Arise from ventral rami C3.4, 5; the only motor innervation for the diaphragm
runs within the fibrous pericardium on its way to innervating the diaphragm
Both L and R phrenic nerves remain anterior to the root of the lungs in the thorax to reach the diaphragm
Term
Vagus Nerve (X)
Definition
originates from the medullar of the vrain and escends through the neck to trach the superior mediastinum where it enters the thorax
Preganglionic parasympathetic motor neurons are located in the medulla (brain stem) while postganglionic nerve cell bodies are located in the terminal organs
Term
Right Vagus
Definition
enters the superior mediastinum on the right side of the trachea and then passes posterior to the right brachiocephalic vein and IVC, stays posterior to the root of the lungs and descends along the esophagus to enter the abdominal cavity.
Term
Left Vagus
Definition
enters the superior mediastinum by descending along the left surface of the arch of the aorta. The left vaus stays well posterior to the root of the lung as it also descends along the esophagus to reach the abdominal cavity
Term
Left vagus nerve
Definition
Term
Recurrent Laryngeal Nerves
Definition
-control the voice box in neck; both from right and left vagus
the right recurrent laryngeal nerve runs under the right subclavian artery
the left recurrent laryngeal nerve runs under the arch of the aorta lateral to the ligamentum arteriosus, which connects the pulmonary trunk to the underside of the aorta.
Term
Recurrent Laryngeal Nerves
Definition
Term
Autonomic Plexuses of the Thorax
Definition
Cardiac, Pulmonary, Esophageal plexus
-mixed plexuses that contain both sympathetic and parasympathetic ribers. the parasympathetic fibers arise from the right and left vagus
T1-T5 contribute sympathetic preganglionic nerves that synapse in the paravertebral sympathetic chain ganglia
pain from the heart, lungs and esophagus can refer pain back to T1-5 dermatomes.
Term
Thoracic Splanchnic Nerves
Definition
Greater (thoracic) splanchnic nerves from T5-t9
Lesser splanchnic nerves from T10-T11
Least splanchnic nerves from T12
some of the splanchnic nerves from T5-12 will skip the paravertebral sympathetic chain ganglia and synapse instead in prevertebral ganglia on their way to innervate abdominal organs
Term
Thoracic duct
Definition
begins in abdomen as cisterna chyli
receives lymph from both sides of thoracic cavity and abdomen
emption intot the junction of the left subclavian and left internal jugular veins
runs anterior tot he vertebral bodies
Term
Chylothorax (lymph in a pleural cavity)
Definition
due to a torn thoracic duct
Term
Azygos system of veins
Definition
-runs cranially/caudally along the right side of the vertebral bodies
connetcs to both the SVC (over the roof of the right lung at the sternal angle) and IVC
Hemizygos - vein on the inferior aspects along the left side of the thoracic vertebrae
Term
Azygos system of Veins (pic)
Definition
Term
Pancoast Syndrome
Definition
apical bronchogenic carcinoma that can impinge on adjacent anatomical structures. Sometimes causing Horner's syndrome (an interruption of sympathetic innervation to the head and neck resulting in ptosis (drooping of the upper eye lid), myosis (constriction of the pupil), and anhydrosis (reduce sweating) unilateral. The patient also may present with neurovascular compromise for the arm with wasting, pain, or paraesthesia (tingling, numbness of skin) most often of the ulnar nerve.
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