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Functions of the Brain
Neuroanatomy Functions of the Brain
254
Anatomy
Graduate
03/12/2012

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Term
what do selective staining procedures teach us about the nervous system
Definition
nissle and golgi methods of staining are useful to reveal cellular organization and diversity within the CNS
Term
purpose of immunohistochemical and molecular biology techniques of studying the nervous system
Definition
identify functional proteins
Term
what is anterograde transport
Definition
transport of substances from the cell body down the axon of the neuron.
Term
what is retrograde transport
Definition
transport of substances from the synapse up the axon to the cell body of the neuron
Term
how is axonal transport studied?
Definition
we can put radioactive amino acids in the cell body. We can follow where the radioactive amino acid goes. We might find it in a synapse in the brainstem or in a synapse all the way down the lumbar spine. Axonal transport of radioactive amino acids helps us follow where the axon goes.
Term
what can radiological techniques teach us about the nervous system
Definition
useful to study 3-d images of brain and brain functions
Term
what does CT stans for
Definition
computerized tomography
Term
when was CT developed
Definition
1970s
Term
what does CT do
Definition
provides a slice or tomogram of various regions within the brain; shows excellent detail between gray and white matter
Term
what is CT
Definition
rotating x-ray
Term
what did CT teach us most about
Definition
taught us most about 3-d aspects of bone
Term
problem with CT
Definition
loads you up with radiation
Term
what does MRI stand for
Definition
magnetic resonance imaging
Term
How does MRI work
Definition
chamber with big electromagnetic field around you produced by magnetic coils. Magnetic fields are so strong that they align protons/electrons in our body. Turn it on and off for a brief second, makes the protons fall then move back up; creates an image on a printer.
Term
how ar MRI's images of the brain
Definition
makes extraordinarily detailed images of the brain
Term
is MRI safe
Definition
noninvasive and safe. Non-x-ray
Term
what is the viewpoint of MRI
Definition
slices can be taken from any plane
Term
how does MRI find pathologies
Definition
can utilize contrast mechanisms (dyes) to highlight pathologic conditions like tumors, hematomas, aneurysms
Term
is MRI good for studying normal brains or pathological issues
Definition
both
Term
what kind of information projects to the calcarine fissure?
Definition
visual
Term
how do we know that visual information projects to the calcarine fissure?
Definition
MRI
Term
do areas of the brain that are very metabolically active contain deoxyhemoglobin or oxyhemoglobin
Definition
deoxyhemoglobin
Term
why do areas that are metabolically active contain deoxyhemoglobin
Definition
they are used often
Term
how does the deoxyhemoglobin appear on MRI
Definition
deoxy has a different magenetic resonance than oxy; shows up differently on MRI
Term
what can we use to follow pathways through the brain, such as the visual pathway as it goes from the projection neuron in the retina to the nucleus in the thalamus to the calcarine fissure and primary visual cortex?
Definition
functional MRIs
Term
What is a PET scan?
Definition
another functional brain imge
Term
what does PET stand for
Definition
Positrion Emission Tomography
Term
what do you have to inject someone with for PET scans to measure brain activity?
Definition
radio-labeled glucose
Term
what are the steps in the visual pathway?
Definition
1. retinal ganglion cells; 2. optic nerve; 3. fibers cross chiasm; fibers project to lateral geniculate nucleus of the thalamus; 4. fibers continue via optic radiations to visual cortex occipital lobe; 5b. Some fibers project to superior colliculi
Term
what are the 3 main parts of the brain?
Definition
cerebrum, brainstem, cerebellum
Term
what (generally) makes up the cerebrum
Definition
cerebral hemispheres and associated lobes; diencephalon
Term
what makes up the brainstem?
Definition
midbrain, pons, medulla oblongata
Term
what is the outer part of the cerebrum?
Definition
cortex
Term
what are the 4 lobs of the cerebral cortex?
Definition
frontal, parietal, occipital, temporal
Term
what are the 3 important nuclei within the cerebral hemispheres
Definition
basal ganglia, hippocampal formation, amygdala
Term
what is enclosed by the 2 hemispheres?
Definition
lateral ventricles
Term
what does the ventricular system produce and circulate?
Definition
cerebral spinal fluid
Term
what does CSF do
Definition
like the lymph of our nervous system. protect and nourish the brain
Term
where is the 3rd ventricle?
Definition
within the diencephalon in the very center of the brain
Term
where is the 4th ventricle
Definition
located on the dorsal aspect of pons and medulla inferior to the cerebral aqueduct
Term
in what space does CSF go to surround the brain?
Definition
subarachnoid space
Term
what structure connects the right and left hemispheres
Definition
corpus callosum
Term
what are commissural fibers
Definition
axons that traverse between the 2 hemispheres thorugh the corpus callosum
Term
what are associative fibers
Definition
axons that project from lobe to lobe within the same hemisphere
Term
what are projection fibers
Definition
axons that ascend to and descend from hemispheres to other regions of the CNS
Term
what is the major connection between the 2 sides of the brain
Definition
corpus callosum
Term
how many axons course through the corpus callosum
Definition
about 200 million
Term
what is the name of the axons that course through the corpus callosum?
Definition
commissural fibres
Term
do associative fibers cross from left to right side of the brain?
Definition
no
Term
what fibers run up and down from brain to brainstem/spinal cord and vice versa?
Definition
projection fibers
Term
what is the biggest lobe in the brain?
Definition
frontal
Term
what is the primary motor cortex?
Definition
area where first neurons originate to help us move.
Term
what initiates motor commands to control voluntary muscles and movements
Definition
primary motor cortex and premotor cortex
Term
where is the primary motor cortex and premotor cortex?
Definition
frontal lobe
Term
what do upper motor neurons do?
Definition
allow voluntary movement
Term
where in relation to the primary motor cortex is the premotor cortex
Definition
premotor cortex is anterior to the primarymotor cortex
Term
where do upper motor neurons originate
Definition
primary motor cortex
Term
if you could only say one word that the frontal lobe is involved with, what would it be?
Definition
personality
Term
if you could say one phrase to describe what the frontal lobe is involved with, what would it be?
Definition
planning and executing behavior
Term
what is Broca's area?
Definition
motor speech center
Term
what lobe is Broca's area in?
Definition
frontal lobe
Term
what happens in the frontal lobe to affect personality
Definition
integration and coordination of neuronal processes that influence personality
Term
what impact does frontal lobe have on behavior
Definition
has to do with planning and executing normal behavior
Term
what are the 4 important functions/areas of the frontal lobe
Definition
personality, normal behavior, Broca's area (speech), primary motor cortex
Term
what is the primary sensory cortex?
Definition
large gyrus that receives afferent neuronal information concerning pain, touch, temperature, and proprioception
Term
what kinds of sensory information goes to the primary sensory cortex
Definition
pain, touch, temperature, and proprioception
Term
where would tickling, squeezing project to in the brain?
Definition
primary sensory cortex
Term
what lobe contains the primary sensory cortex?
Definition
parietal lobe
Term
what does the parietal lobe do other than having the primary sensory cortex
Definition
parietal lobe integrates and coordinates neuronal processes that influence our attention and perceputal awareness of our surroundings
Term
what is the language comprehension center?
Definition
Wernicke's area
Term
what lobe houses Wernicke's area?
Definition
temporal lobe
Term
where is the primary auditory and olfactory complex?
Definition
temporal lobe
Term
where is the primary visual cortex?
Definition
occipital lobe
Term
other than having the primary auditory and olfactory cortexes and Wernicke's area, what does the temporal lobe do?
Definition
integrates and coordinates neuronal processes that influence our recognition and identification of objects
Term
when you hear someone talk, where does that project?
Definition
temporal lobe
Term
when you smell something, where does that project?
Definition
temporal lobe
Term
what lobe is involved with recognition of objects, faces, common things?
Definition
temporal lobe
Term
what are association cortices?
Definition
regions of the cerebral cortex not involved with sensory or motor processing
Term
what types of processing are association cortices involved with
Definition
cognitive processes
Term
what are some examples of cognitive processes
Definition
likes, dislikes, fears, jealousies, anger, happiness: the things that make us human
Term
define language
Definition
the comprehension and communication of abstract ideas
Term
what is the name of the motor speech area
Definition
Broca's
Term
what lobe houses Broca's area
Definition
frontal lobe
Term
what parts of speech depend on Broca's area
Definition
The ability to think the right words; translating one's thoughts into speech; assembling words into meaninginful sentences
Term
which hemisphere of the brain contains Broca's area
Definition
in the left hemisphere in 90% of people
Term
what is the language comprehension center?
Definition
Wernicke's area
Term
what aspect of language depends on Wernicke's area
Definition
the ability to comprehend language
Term
where in the temporal lobe is Wernicke's area?
Definition
posterior, superior part of temporal lobe
Term
is Wernicke's usually in the left or right hemisphere?
Definition
in the left hemisphere in 90% of people
Term
what is the arcuate fasciculus?
Definition
axonal pathway that connect the speech comprehension area (Wernicke's) to the speech production area (Broca's)
Term
what kind of axon fibers are in the arcuate fasciculus?
Definition
associative fibers
Term
define aphasia
Definition
loss or impairment of language function as a result of brain damage
Term
what are the 3 most common aphasias
Definition
Broca's aphasia, Wernicke's aphasia, global aphasia
Term
what causes the different aphasias
Definition
lesions to the specific regions of the brain
Term
what is another term for Broca's aphasa
Definition
expressive aphasia
Term
what causes Broca's aphasia
Definition
lesion/stroke to Broca's area of the frontal lobe
Term
what are the Brodmann's areas of Broca's area?
Definition
44, 45
Term
what does Broca's aphasia often go along with?
Definition
hemiplegia caused by damage to adjacent motor cortex
Term
can someone with Broca's aphasia comprehend spoken language normally?
Definition
yes
Term
what is the result of Broca's aphasia
Definition
Can't express what they want to say. Fluency is impaired. Difficulty naming simple objects. Ability to repeat simple phrases is impaired.
Term
are patients with Broca's aphasia aware of their deficit?
Definition
yes. It's frustrating
Term
if someone with broca's aphasia sees a quarter on the table, what happens?
Definition
they know what it is, but it's hard for them to put syllables together. They can't say the name. It's frustrating.
Term
does domeone with Broca's aphasia have difficulty with writing
Definition
yes; they might write the 2nd syllable before the 1st syllable
Term
how does Broca's aphasia affect deaf people?
Definition
they have difficulty signing
Term
what is the Brodmann's area of the primary motor cortex?
Definition
4
Term
what are Brodmann's areas
Definition
histologically and functionally similar areas of the brain
Term
what is another term for Wernicke's aphasia
Definition
receptive aphasia
Term
What Brodmann's area is Wernicke's area?
Definition
22
Term
is hemiplegia associated with Wernicke's aphasia?
Definition
no
Term
describe what happens to someone with Wernicke's aphasia
Definition
speak with normal grammar, syntax, rate, intonation, and stress, but their language content is correct. Speech is fluent but comprehension is impaired. Nonsensical words are often used and speech may be circumlocatory (wordy but meaningless.)
Term
are patients with Wernicke's aphasia aware of their deficit?
Definition
they are unconcerned or unaware
Term
what other problem sometimes happens along with Wernicke's aphasai because of its proximity in the brain
Definition
auditory problems
Term
what causes global aphasia
Definition
large lesions affect both Broca's and Wernicke's along with the interconnecting arcuate fasciculus
Term
what is impared in global aphasia?
Definition
comprehension, fluency, and repetition
Term
Can Broca's and Wernicke's aphasias ever be improved?
Definition
yes, after swelling goes down and with speech therapy
Term
what is the basal ganglia
Definition
important nuclei deep within the cerebral hemispheres that modulate motor control
Term
what are the 3 major nuclei of the basal ganglia?
Definition
caudate, putamen, globus pallidus
Term
what do the basal ganglia do?
Definition
supervise motor movements of the eyes, trunks, and limbs (posture and voluntary movements) by regulating upper motor neurons
Term
what do the basal ganglia supervise?
Definition
motor control
Term
what is the shape of the caudate?
Definition
C-shaped
Term
what courses between the caudate and the putamen nuclei?
Definition
internal capsule
Term
what is the internal capsule
Definition
axonal pathway between spinal cord and brain
Term
what types of fibers are the axons that go through the internal capsule?
Definition
projection: they go from brain to spinal cord and from spinal cord to brain
Term
what are 2 diseases of the basal ganglia?
Definition
huntington's, parkinson's
Term
what happens with huntington's disease?
Definition
involuntary movements due to atrophy of the caudate and putamen nuclei. The loss of the supervision of motor control means you can't stop moving
Term
how do you get huntington's disease
Definition
autosomal inherited disease
Term
is huntington's disease fatal?
Definition
yes
Term
what happens in parkinson's disease
Definition
loss of dopamine neurons that innervate the caudate and putamen causes too much supervision of motor control. Become locked in, can't move.
Term
what is another name for basal ganglia
Definition
striatum
Term
what are some symptoms of parkinson's
Definition
resting tremor (pill rolling hand movements), bradykinesia, rigidity, difficulty with balance
Term
what is bradykinesia
Definition
slowness of movement
Term
in what lobe are the hippocampus and amygdala?
Definition
temporal lobe
Term
what is the major function of the hippocampus
Definition
learning and memory
Term
what do the amygdala and hypothalamus help coordinate
Definition
emotional behavior
Term
what is the deepest region of the brain
Definition
diencephalon
Term
what are the 4 parts of the diencephalon
Definition
thalamus, hypothalamus, epithalamus, subthalamus
Term
what is the thalamus/what does it do?
Definition
major relay center: processes sensory information and regulates motor control
Term
what is the hypothalamus/what does it di?
Definition
key control center for the autonomic nervous system: regulates reproductive and homeostasis functions (hunger, body temperature, water balance)
Term
what is the epithalamus/what does it do?
Definition
pineal gland. Circadian rhythm, light/dark cycles
Term
what is the subthalamus involved in?
Definition
motor control
Term
what does the diencephalon surround
Definition
3rd ventricle
Term
what part of brain does sensory information enter before going to other parts of the brain?
Definition
thalamus
Term
what part of the brain does motor information go to before leaving the brain?
Definition
thalamus
Term
what gland is hypothalamus connected to?
Definition
pituitary
Term
how are the thalamus and the cerebral cortex linked?
Definition
closely linked both anatomically and functionally via projection fibers
Term
what is the shaple of the thalamus
Definition
egg-shaped/buffalo-shaped/somewhat C shaped
Term
is the thalamus white or gray matter?
Definition
gray
Term
what does the thalamus surround?
Definition
3rd ventricle
Term
what is in the anterior, medial, and lateral parts of the thalamus?
Definition
numerous nuclei that relay sensory information to other brain regions
Term
what is in the posterior aspect of the thalamus?
Definition
medial and lateral geniculate bodies
Term
what is another term for the posterior portion of the thalamus
Definition
pulvinate
Term
to what parts of the thalamus does a lot of the sensory information of our body go?
Definition
ventral posteromedial and ventral posterolateral nuclei
Term
what does the cerebral aqueduct go through to get from the 3rd to 4th ventricle?
Definition
midbrain
Term
what cranial nerves originate in the midbrain?
Definition
3, 4
Term
where are the cerebral peduncles?
Definition
lateral sides of the midbrain
Term
what are the cerebral peduncles?
Definition
axon fiber tracts that go from cortex to spinal cord
Term
where are the superior and inferior colliculi
Definition
midbrain
Term
what kind of stimuli do the superior and inferior colliculi respond to?
Definition
visual and auditory stimuli
Term
where is the substantia nigra?
Definition
midbrain
Term
what does the substantia nigra do?
Definition
produces dopamine
Term
what is dopamine important for
Definition
motor control
Term
where is the oculomotor complex?
Definition
midbrain
Term
what makes up the oculomotor complex
Definition
oculomotor nuclei and Edinger Westphal nuclei
Term
what are the names of the cranial nerves that originate in the midbrain?
Definition
oculomotor, trochlear
Term
what is the red nucleus?
Definition
rubrospinal tract origination (an upper motor neuron tract)
Term
where is the red nucleus?
Definition
midbrain
Term
what is the tectum?
Definition
the roof of the midbrain
Term
what kind of fibers are in the cerebral peduncles?
Definition
projection fibers
Term
what do the cerebral peduncles continue as into the brain?
Definition
internal capsule
Term
what is the tegmentum
Definition
floor of the midbrain
Term
what are the colliculi collectively referred to as?
Definition
corpora quadrigemina
Term
what types of projection fibers go through the internal capsule/
Definition
ascending fibers come up to sensory cortex; descending fibers go to the spinal cord and brainstem
Term
where do ascending fibers going through internal capsule go to?
Definition
primary sensory cortex in the postcentral gyrus
Term
what are 2 other names for the descending motor fibers that go through the internal capsule to the spinal cord and brainstem?
Definition
corticospinal tracts; upper motor neurons
Term
what does the internal capsule go between
Definition
caudate and putamen AND basal ganglia and thalamus
Term
what cranial nerves originate in the pons?
Definition
5, 6, 7, part of 8
Term
what are the names of the cranial nerves that originate in the pons?
Definition
trigeminal, abducens, facial, vestibular
Term
what types of fibers go through the pons?
Definition
projection (ascending and descending)
Term
what cranial nerves originate in the medulla oblongata?
Definition
part of 5,part of 8, 9, 10, 12
Term
what are the names of the cranial nerves that originate in the medulla oblongata?
Definition
trigeminal, vestibular, glossopharyngeal, vagus, hypoglossal
Term
what part of the vagus nerve originates in the medulla?
Definition
dorsal motor nuclei of vagus
Term
what part of the trigeminal nerve originates in the medulla?
Definition
spinal nucleus
Term
where are the solitary nuclei?
Definition
medulla oblongata
Term
where are the pyramides?
Definition
medulla oblongata
Term
what are the pyramids
Definition
motor projection fibers = upper motor neurons = corticospinal tracts
Term
where are the olives
Definition
medulla oblongata
Term
what are the olives
Definition
important relay nuclei that project to the cerebellum
Term
what is the cerebellum important for?
Definition
coordination: helps to organize our movements
Term
how many hemispheres in the cerebellum?
Definition
2
Term
what connects the hemispheres of the cerebellum?
Definition
vermis
Term
essential function of thte cerebellum
Definition
coordination of all voluntary muscle activity
Term
what else does the cerebellum do
Definition
harmonize muscle tone and maintain normal body posture and equilibrium; filters errors in motor movements/uncoordinated movements
Term
what are the 4 major nuclei within the cerebellum
Definition
fastigial nucleus; interposed nuclei (2); dentate nucleus
Term
what do the deep nuclei of the cerebellum do?
Definition
integrate information within the cerebellum and project UMNs throughout the cortex and brainstem to help harmonize and coordinate motor movements
Term
If I damage the left side of my brain, what side of my body is affected?
Definition
right
Term
if I damage the left side of my cerebellum what side of my body is affected?
Definition
left
Term
lesions on one side of the cerebellum affect what side of the body?
Definition
ipsilateral
Term
what are the symptoms of cerebellar disease?
Definition
hypotonia, action tremor, ataxia
Term
what is hypotonia
Definition
loss of normal muscle tone
Term
what are action tremors
Definition
tremors with fine movements
Term
what is ataxia
Definition
clumsy or uncoordinated gait alterations
Term
what comes up through the solitary nucleus?
Definition
lots of GVA neurons
Term
in what general region of the brain are most cranial nerve nuclei found?
Definition
brainstem
Term
for what is the brainstem a thruway?
Definition
ascending sensory and descending motor tracts
Term
describe vascularity of brainstem
Definition
many important things in a small volume area; restricted vascular supply
Term
are motor nuclei medial or lateral in the brainstem
Definition
medial
Term
are sensory cranial nerve nuclei medial or lateral in the brainstem?
Definition
lateral
Term
if I get a stroke in the medial side of my brainstem, what cranial nerves do I lose
Definition
motor
Term
what do internal carotid arteries give rise to in the brain?
Definition
middle and anterior cerebral arteries
Term
what do the verebral arteries become in the brain?
Definition
first they form the basilar artery. Basilar artery becomes the posterior cerebral arteries
Term
how are the major arteries of the brain connected
Definition
by communicating vessels
Term
what does the anterior cerebral artery vascularize?
Definition
anterior aspect of the brain along the midline
Term
what does the middle cerebral artery vascularize?
Definition
lateral sides of the brain
Term
what does the posterior cerebral artery vascularize?
Definition
the posterior/inferior aspect of the brain and midbrain
Term
what does the anterior cerebral artery course along to supply the midline regions of the brain?
Definition
corpus callosum
Term
what vascularizes the internal capsule and basal ganglia?
Definition
lenticulostriatal branches from the middle cerebral artery
Term
what are ganglia?
Definition
local accumulations of nerve cell bodies found within the peripheral nervous system
Term
what are nuclei
Definition
collections of nerve cells found within the central nervous system. Nuclei are anatomically discrete and have similar connections and functions
Term
what type of nerve cell bodies reside in the dorsal root ganglia?
Definition
sensory
Term
what type of nerve cell bodies reside in the sympathetic chain?
Definition
sympathetic
Term
what is a nerve?
Definition
collection of peripheral axons enveloped by schwann cells that are bundled together and travel a common route. Nerves are found in the PNS.
Term
what are tracts?
Definition
axons enveloped by oligodendrocytes and bundled together in the CNS
Term
what is gray matter?
Definition
an accumulation of cell bodies found within the CNS
Term
what is white matter?
Definition
axon tracts in the CNS
Term
why is white matter white?
Definition
axon tracts are myelinated
Term
are nuclei white or gray?
Definition
gray
Term
are fasciculas white or gray?
Definition
white
Term
is the cortex white or gray?
Definition
gray
Term
are nerves white or gray?
Definition
white
Term
are axon tracts white or gray?
Definition
white
Term
what happens at the dorsal horn of the spinal cord?
Definition
dorsal horn receives sensory/afferent information that enters the spinal cord via the dorsal roots of spinal nerves
Term
what things are at the ventral horn of the spinal cord?
Definition
cell bodies of lower motor neurons
Term
where do the LMN axons from ventral horn go?
Definition
out the ventral root to striated muscle
Term
what are the parts of the gray matter in the spinal cord
Definition
dorsal horn, ventral horn, lateral horn
Term
what parts of the spinal cord have lateral horns?
Definition
thoracic regions: T1-L2
Term
what happens in the lateral horn?
Definition
preganglionic visceral motor neurons project to sympathetic ganglia
Term
what is the white matter of the spinal cord divided into?
Definition
4 columns: dorsal, lateral, ventral-lateral, ventral
Term
what are the dorsal columns
Definition
carry ascending sensory information from somatic receptors (touch, pressure)
Term
what kinds of information travels in the dorsal columns?
Definition
ascending sensory: touch, pressure
Term
purpose of lateral columns
Definition
conveys descending motor axons/UMNs that travel from the cerebral cortex to the spinal cord
Term
what is another name for Upper Motor Neurons
Definition
corticospinal tracts
Term
function of ventral-lateral columns
Definition
carry ascending sensiory information concerning pain and temperature
Term
function of ventral columns
Definition
also convey descending motor information from the cortex (UMNs)
Term
where does mechanical sensory information travel to go up to the brain
Definition
dorsal columns
Term
where do upper motor neurons travel in the spinal cord
Definition
lateral columns and ventral columns
Term
where do pain and temperature travel as they go up into your brain
Definition
ventral-lateral columns
Term
are dorsal horns sensory or motor?
Definition
sensory
Term
are ventral horns sensory or motor
Definition
motor
Term
what is the spinal cord commissure
Definition
connection between the gray matter across the middle of the spinal cord
Term
what vascularizes the spinal cord?
Definition
branches of the vertebral artery: anterior spinal artery and posterior spinal artery
Term
what vascularizes the anterior 2/3 of the spinal cord
Definition
anterior spinal artery
Term
what vascularizes the dorsal columns of the spinal cord?
Definition
posterior spinal arteries
Term
what would be lost if a posterior spinal artery is occluded?
Definition
mechanical sensory
Term
what would be lost if an anterior spinal artery is occluded?
Definition
pain, motor
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