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Fundamentals of Adrenergics
Receptor types and affinites for catecholamines and their tissue distribution
10
Pharmacology
Professional
08/29/2011

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Cards

Term
α-adrenergic receptor affinities for catecholamines
Definition
Epi > or ~ = NE > ISO
Term
β1-adrenergic receptor affinity for catecholamines
Definition
Iso > Epi = NE
Term
β2 adrenergic receptor affinity for catecholamines
Definition
Iso ≥ Epi >> NE
Term
Heart adrenergic receptors and action
Definition

β1 receptors

- increases heart rate (SA node)

- increases conduction rate and shorter functional refractory period (AV node)

- increases contractility (ventricles)

Term
Adrenergic receptors of blood vessel smooth muscle
Definition

To skinα → contraction of smooth muscle

 

To skeletal muscleα and β1 → contraction and relaxation

respectively

Term
Bronchial smooth muscle receptors
Definition
β2 → dilation of bronchi
Term
GI smooth muscle adrenergic receptors
Definition

To stomach - β → decreased motility

 

To intestines - α & β → decreased motility

Term
GI sphincter adrenergic receptors
Definition

To stomach - α → contracts

 

To intestines - α → contracts

Term
Urinary bladder adrenergic receptors
Definition

Detrussor muscle:  β → relaxation and filling of bladder

 

Trigone and sphincter:  α → contract

Term
Eye muscle adrenergic receptors
Definition

Radial m.      α → contract

 

 

Ciliary m.      β → relax

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