Term
| Describe efficacy and potency on dose-effect curves? |
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Definition
Left shift: increases potency
Upward Shift: increases efficacy |
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Term
| Difference between Physiological and Pharmacological Antagonists |
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Definition
Physio: Counter effect by different mechanism
Pharmaco: Counter effect by blocking same mechanism |
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Term
| Mechanisms of non-competitive antagonists |
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Definition
Irreversibly bing receptor site
Bind Allosterically |
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Term
| How do competitive and noncompetive antagonists affect effacacy and potentcy |
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Definition
Competitive: Potency decreases
Non-competitive: Efficacy Decreases |
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Term
| What are partial and inverse agonists |
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Definition
Inverse: Down regulates constituatively active receptors
Partial: Exhibit effect to a lesser degree that the physiological ligands decreasing effects, but maintaining some activity |
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Term
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Definition
| Enzymatic processes are saturated before the receptors are |
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Term
| What is the Margin of Safety and the Therapedic Index |
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Definition
Margin of Safety: LD1/ED99
Therapeudic Index: TD50/ED50 |
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