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What is an organism’s DNA, with its arrays of genes, organized into structures? |
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What are two major processesinvolved in the genetic continuity of nucleated cells? |
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What is the genetic material making up chromosomes (unfolds and uncoils) into a diffuse network within the nucleus not undergoing division? |
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What is an outer covering that defines the cell boundary and delimits the cell from its immediate external environment? |
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What is an outer covering whose major component is a polysaccharide called cellulose in plant cells? |
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Animal cells have a covering over the plasma membrane, referred to as the? |
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Molecules that act as recognition sites that transfer specific chemical signals across the cell membrane into the cell are? |
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The presence of a nucleus and other membranous organelles is the defining characteristic of __________. |
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What is a membrane-bound structure that houses the genetic material, DNA, which is complexed with an array of acidic and basic proteins into thin fibers in eukaryotic cells? |
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What is an amorphous component where ribosomal RNA (rRNA) is synthesized and where the initial stages of ribosomal assembly occur? |
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What are portions of DNA that encode rRNA are collectively referred to as the ________. |
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Definition
nucleolus organizer region (NOR) |
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What lacks a nuclear envelope and membranous organelles? |
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What is a long, circular DNA molecule that is compacted into an unenclosed region? |
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What is the remainder of the eukaryotic cell within the plasma membrane that includes a variety of extranuclear cellular organelles? |
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What is a nonparticulate, colloidal material that surrounds and encompasses the cellular organelles? |
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What is an organelle that compartmentalizes the cytoplasm, greatly increasing the surface area available for biochemical synthesis? |
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endoplasmic reticulum (ER) |
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What are sites where genetic information contained in messenger RNA (mRNA) is translated into proteins? |
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__________ is found in most eukaryotes, including both animal and plant cells, and are the sites of the oxidative phases of cell respiration. These chemical reactions generate large amounts of the energy-rich molecule adenosine triphosphate (ATP). |
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What is found in plants, algae, and someprotozoans,and are associated with photosynthesis, the major energy-trapping process on Earth? |
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Animal cells and some plant cells also contain a pair of complex structures called ________. |
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What are cytoplasmic bodies located in a specialized region? |
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These play an important role in the movement of chromosomes as they separate during cell division. They are composed of arrays of microtubules consisting of polymers of the protein tubulin. |
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What is a constricted region, whose location establishes the general appearance of each chromosome? |
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What is the shorter arm above the centromere? |
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What is the longer arm below the centromere? |
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somatic cells derived from members of the same species contain this identical number of chromosomes. |
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When the lengths and centromere placements of all such chromosomes are examined with the exception of sex chromosomes, they exist in pairs with regard to these two properties, and the members of each pair are called |
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the physical appearance of different pairs of homologous chromosomes |
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chromosomes is equal to one-half the diploid number. |
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the genetic information contained in a haploid set of chromosomes |
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Homologous chromosomes contain identical gene sites along their lengths called |
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In a population of members of the same species,many different alternative forms of the same gene called |
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single-celled fertilized eggs in a multicellular diploid organism |
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genetic material is partitioned into daughter cells during nuclear division, |
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Karyokinesis is followed by cytoplasmic division or _________ |
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events that occur from the completion of one division until the completion of the next division |
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the initial stage of the cell cycle and the replication of the DNA of each chromosome. |
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This period, during which DNA is synthesized,occurs before the cell enters mitosis |
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Investigations of this nature demonstrate two periods during interphase when no DNA synthesis occurs, one before and one after the S phase.During both of these intervals, as well as during S, intensive metabolic activity, cell growth, and cell differentiation are evident. |
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By the end of G2, the volume of the cell has roughly doubled, DNA has been replicated, and ________ is initiated. |
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one of the early stages of this event is migration of two pairs of centrioles to opposite ends of the cell. |
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two parts of each chromosome are ______ _______ because the DNA contained in each of them is genetically identical, having formed from a single replicative event. |
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Sister chromatids are held together by a multi-subunit protein complex called |
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the period of chromosome movement |
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the chromosome configuration following migration. |
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unique protein family protects cohesin from being degraded by separase at the centromeric regions. |
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During this phase, sister chromatids of each chromosome, held together only at their centromere regions, disjoin from one another and are pulled to opposite ends of the cell. |
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migrating chromosome as anaphase proceeds |
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At its beginning of this final stage of mitosis, two complete sets of chromosomes are present, one set at each pole. The most significant event of this stage is cytokinesis, the division or partitioning of the cytoplasm. |
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Checkpoint that monitors the size the cell has achieved since its previous mitosis and also evaluates the condition of the DNA. |
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checkpoint where DNA is monitored prior to the start of mitosis. |
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checkpoint where the successful formation of the spindle fiber system and the attachment of spindle fibers to the kinetochores associated with the centromeres are monitored. |
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M checkpoint (Spindle Assembly checkpoint) |
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first division in meiosis I (because the number of centromeres, each representing one chromosome, is reduced by one-half).2n to n |
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second division during meiosis II (because the number of centromeres remains equal); sister chromatids separated into daughter cells |
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First, as in mitosis, chromatin present in interphase thickens and coils into visible chromosomes. And each chromosome is a double structure, held together by the molecular complex called cohesin. Second, unlike mitosis, members of each homologous pair of chromosomes pair up, undergoing synapsis. Third, crossing over occurs between chromatids of synapsed homologs. |
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homologous chromosomes form pairs; that is, they synapse (or undergo) _________. |
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During the leptotene stage, the interphase chromatin material begins to condense, and the chromosomes, though still extended, become visible; where chromosome fibers begin to condense |
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The chromosomes continue to shorten and thicken during the zygotene stage;where each homologous chromosome pair is joined together by a synaptonemal protein complex. The process is called synapsis and the synapsed chromosomes are called bivalent or tetrads (four chromatids) |
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In the transition from the zygotene to the pachytene stage, the chromosomes continue to coil and shorten, and further development of the synaptonemal complex occurs between the two members of each bivalent.This leads to synapsis, a more intimate pairing; where DNA exchanges occur between non-sister chromatids. A cross-shaped structure called a chiasma (chiasmata plural) forms at the point of exchange. |
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During the ensuing diplotene stage, it is even more apparent that each tetrad consists of two pairs of sister chromatids. Within each tetrad, each pair of sister chromatids begins to separate; where the synaptonemal complex begins to disappear but chiasmata is still visible;where the synaptonemal complex begins to disappear but chiasmata is still visible |
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The final stage of prophase I chromosomes pull farther apart, but nonsister chromatids remain loosely associated at the chiasmata. As separation proceeds, the chiasmata move toward the ends of the tetrad; Chromosomes are maximally condensed and chiasmata migrate toward the ends of the chromosome. Homologous pairs begin to pull away from each other so chiasmata are clearly seen. Nucleoli and nuclear membrane disappear and spindle apparatus begin to form. |
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the chromosomes have maximally shortened and thickened. The terminal chiasmata of each tetrad are visible and appear to be the major factor holding the nonsister chromatids together;Bivalents (tetrads) are oriented on the equatorial plane. |
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Cohesin is degraded between sister chromatids,except at the centromere region, which, as in mitosis, is protectedby a shugoshin complex. Then, one-half of each tetrad(a dyad) is pulled toward each pole of the dividing cell;Chiasmata dissolve, centormeres do not separate so whole chromosomes (2 sister chromatids) move to opposite poles of the cell. This reduces the chromosome number from 2n to n. |
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reveals a nuclear membrane forming around the dyads; is completed when the nuclear membrane reforms around the chromosomes at either end of the cell. |
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is essential if each gamete or spore is to receive only one chromatid from each original tetrad. |
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each dyad is composed of one pair of sister chromatids attached by the common centromeric region;Spindle apparatus reforms and chromosomes re-condense |
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the centromeres are positioned on the equatorial plate,the shugoshin complex is degraded, and the centromeres separate; Chromosomes line up along the equatorial plane. |
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reveals one member of each pair of homologous chromosomes present at each pole. Each chromosome is now a monad; Nuclear membranes reform around chromosomes at opposite poles. |
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In ____________, the formation of ova (sing. ovum), or eggs, occurs in the ovaries, the female reproductive organs |
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M phase is itself composed of two tightly coupled processes:________, in which the cell's chromosomes are divided between the two daughter cells, and ___________, in which the cell's cytoplasm physically divides |
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Cells that have temporarily or reversibly stopped dividing are said to have entered a state of _________ called G0 phase |
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cells that have permanently stopped dividing due to age or accumulated DNA damage are said to be |
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The first phase within interphase is called __ ; during this phase the biosynthetic activities of the cell, which had been considerably slowed down during M phase, resume at a high rate; Required for cell growth and preparation of DNA synthesis |
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phase starts when DNA synthesis commences, when it is complete, all of the chromosomes have been replicated; synthesis and replication of genome |
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is required for cell growth and cell division into two daughter cells. |
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phase is needed or cell growth and preparation of mitosis |
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phase in which cells segregate duplicated chromosomes |
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Upon perturbation of DNA replication by drugs that interfere with DNA synthesis,cells activate ______ that arrests cell cycle at G2/M transition until DNA replication is complete |
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Definition
DNA replication checkpoint |
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arrests cell cycle at M phase until all chromosomes are aligned on spindle. |
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detects abnormality in the cytoskeleton and arrests cell cycle at G2/M transition. |
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division of a haploid (n) or diploid (2n) cell into two duplicate daughter cells;the division of a nucleus (karyokinesis) into two duplicate nuclei, each with identical sets of chromosomes.(duplication) |
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special kind of cell division in which the chromosome number is reduced in half. This is how the chromosome number in a life cycle changes from diploid (2n) to haploid (n). (reduction) |
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Cytoplasmic division initiated by the assembly of contractile elements at the equatorial plate in animal cells |
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Centromeres split and separated chromosomes are pulled to opposite poles of the cell. |
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