Term
|
Definition
many possible causes
prerenal, renal, postrenal
prerenal proteinuria caused by hemoglobinuria or Bence-Jones proteinuria
renal proteinuria not always caused by pathologic changes in kidneys |
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Term
|
Definition
due to strenuous exercise and fever
altered renal physiology but no renal lesions |
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Term
|
Definition
due to structural/functional lesions of kidneys
in glomerulus, tubules, interstitium |
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Term
| Most Common Glomerular Diseases in Dogs and Cats |
|
Definition
renal amyloidosis
glomerulonephritis |
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Term
| Glomerular Disease Clinical Findings |
|
Definition
can occur at any age
most common in middle-aged or older dogs
less common in cats
often secondary to another disease
familial disease often manifests at early age
breeds with familial glomerular disease |
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Term
| History with Glomerular Disease |
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Definition
clinical signs vary depending on severity and presence/absence of renal failure
many are asymptomatic
may exhibit signs specific to underlying disease
nonspecific signs of weight loss and lethargy
sign consistent with chronic renal failure/uremia like PU/PD, anorexia, vomiting, malodorous breath
may present with signs of acute renal failure
with severe protein loss can see ascites/edema, thromboemobolism (dyspnea, loss of limb function)
can see signs of hypertension |
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Term
| Physical Findings with Glomerular Disease |
|
Definition
unremarkable
nonspecific signs of systemic illness
poor body condition/poor hair coat
oral ulcerations/pale mucous membranes, dehydration
may have subcutaneous edema/ascites
may have dyspnea or decreased peripheral pulse
overt systemic illness
small or large kidneys |
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Term
| Clinical Pathology/Imaging |
|
Definition
protienuria with no inflammation/hematuria in sample
glomerular tubular imbalance
renal azotemia with intact concentrating ability
may have isosthenuria
hyaline casts
hypoprooteinemia/hypoalbuminemia
azotemia, hyperphosphatemia, metabolic acidosis
nonregenerative anemia |
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Term
|
Definition
proteinuria
hypoalbuminemia
hypercholesterolemia
accumulation of transudates interstitially
urinary protein loss caused by glomerular disease
presence of nephrotic syndrome signifies poorer prognosis in dogs with nonazotemic glomerular disease |
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