Term
Calculate the M:E Ratio from the following BM differential count of 500 cells:
Myeloblasts - 10
Promyelocytes - 20
Myelocytes - 105
Metamyelocytes - 180
Segs - 80
Rubriblasts - 0
Prorubricytes - 10
Rubricytes - 25
Metarubricytes - 25
Plasma Cells - 5
Lymphocytes - 35
Monocytes - 5 |
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Definition
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Term
Is the below M:E Ratio Normal?
BM differential count of 500 cells:
Myeloblasts - 10
Promyelocytes - 20
Myelocytes - 105
Metamyelocytes - 180
Segs - 80
Rubriblasts - 0
Prorubricytes - 10
Rubricytes - 25
Metarubricytes - 25
Plasma Cells - 5
Lymphocytes - 35
Monocytes - 5 |
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Definition
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Term
| What is a normal M:E Ratio? |
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Definition
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Term
| When a M:E Ratio is NOT Normal, what is the term that is used to describe this marrow? |
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Definition
| Myeloid Hyperplasia or Erythroid Hypoplasia |
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Term
| On a BM tap that yields a dry specimen, Wright stain smears could be prepared from: |
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Definition
| Touch prep slide from trephine biopsy |
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Term
When examining the BM smear on Low magnification 10X objective (initial scan), the tech is examining for ALL of the following EXCEPT:
A. BM Cellularity
B. # & Distribution of Megakaryocytes
C. Nonyhematopoietic tumor cells infiltrating BM
D. Details of nuclear & cytoplasmic maturation process |
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Definition
| D. Details of nuclear & cytoplasmic maturation process |
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Term
| In the estimation of BM Cellularity, the cellularity is reflected in the ratio of Nucleated hematopoietic cells to: |
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Definition
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Term
| The cells found in LARGEST Concentration in a Normal adult BM are: |
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Definition
| Granulopoietic and Erythropoietic Precursors |
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Term
| The name of the LARGEST Cell in the normal marrow that Produces Platelets is: |
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Definition
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Term
| When observing a BM Smear, the technologist observes that only fat and connective tissue are formed. This is found in individuals with: |
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Definition
| Aplastic anemia or chemotherapy |
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Term
| The major iron storage compound is: |
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Definition
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Term
Match the BM findings with the listed anemias:
Aplastic Anemia |
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Definition
| Fat to cell ration of 90:10 |
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Term
Match the BM findings with the listed anemias:
Hemolytic Anemia |
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Definition
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Term
Match the BM findings with the listed anemias:
Megaloblastic Anemia |
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Definition
| Large, basophilic RBC precursors with asynchrony, karyorrhexis and "moth eaten" nuclei |
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Term
Match the BM findings with the listed anemias:
Sideroblastic Anemia |
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Definition
| Increased ringed sideroblasts |
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Term
Match the BM findings with the listed anemias:
Iron Deficiency Anemia |
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Definition
| Small, pale RBC precursors with jagged cytoplasm, absent Iron |
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Term
Match the following disorders with their descriptions:
CLL |
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Definition
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Term
Match the following disorders with their descriptions:
Multiple Myeloma |
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Definition
| 80% Immature and multi-nucleated plasma cells |
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Term
Match the following disorders with their descriptions:
CML |
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Definition
M:E ratio of 20:1
Immature granulocytes
Increased Eos & Basos |
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Term
Match the following disorders with their descriptions:
ALL |
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Definition
>30 blasts
+PAS
Other Stains Negative |
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Term
Match the following disorders with their descriptions:
M1 AML |
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Definition
| >30 blasts with Auer Rods |
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Term
Match the following disorders with their descriptions:
M4 AML |
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Definition
>30 blasts
+ Specific esterase
+ Non-specific esterase |
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Term
Match the following disorders with their descriptions:
Metastatic tumor |
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Definition
| Large cells in tight clumps with INCREASED NC ratio and Giant Nucleoli |
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Term
Match the following disorders with their descriptions:
Lipid storage disorders (Niemann-Pick or Gaucher's) |
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Definition
| Increased histiocytes with ingested fat |
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Term
Match the hematology stains with their use:
Demonstrate ringed sideroblasts |
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Definition
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Term
Match the hematology stains with their use:
Stain for trephine biopsy or clot section |
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Definition
| H&E or other histologic stain |
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Term
Match the hematology stains with their use:
Positive (+) in Sezary Cells |
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Definition
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Term
Match the hematology stains with their use:
Routine BM Aspirate Smears |
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Definition
Wright Stain
Prussian Blue |
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Term
Match the hematology stains with their use:
Used to diagnose Myelofibrosis |
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Definition
| Reticulin or silver stain |
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Term
Match the hematology stains with their use:
Positive in M6 & M7 Leukemia |
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Definition
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Term
Match the hematology stains with their use:
Positive in Hairy Cell Leukemia |
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Definition
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Term
Match the hematology stains with their use:
Stains Iron Blue |
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Definition
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Term
| Which bones in an adult contain active bone marrow tissue? |
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Definition
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Term
| What are examples of Flat bones where active bone marrow tissue can be found? |
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Definition
| Skull, Ribs, Vertebrae, & Hip |
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Term
| The TdT stain is POSITIVE in: |
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Definition
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Term
| Why do patients with Polycythemia vera and other myeloproliferative disorders have reduced marrow iron stores? |
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Definition
| They have HIGH Cell Turnover including RBCs. INCREASED production of RBCs INCREASES the need for Iron & Iron Stores are REDUCED. |
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Term
| Why do patients with thalassemia have INCREASED Iron Stores? |
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Definition
| Thalassemia patients require continual blood transfusions. The body holds on to this extra iron and stores it. Also, ferritin is an acute phase reactant & when increased from inflammation, interferes with Iron metabolism thus allowing for Increased Iron stores but inadequate Iron available for normal RBC production. |
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Term
| If an immature lymphoid cell has a surface immunoglobulin, it is a ______. |
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Definition
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Term
| Why do patients with chronic disease have INCREASED Iron Stores? |
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Definition
| Activated macrophages in chronic disease hold on to iron, preventing the stored iron from getting to the bone marrow for RBC production. Also, ferritin is an acute phase reactant & when increased from inflammation, interferes with Iron metabolism thus allowing for Increased Iron stores but inadequate Iron available for normal RBC production. |
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