Term
Lymphoma associated with activation of
C-myc |
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Definition
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Term
Most common form of non-Hodgkin lymphoma
neoplastic proliferation of large B cells that grows in sheets |
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Definition
| Diffuse large B-cell lymphoma |
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Term
t(14;18)
Neoplastic proliferation of small B cells |
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Definition
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Term
Neoplastic proliferation of mature CD4 Tcells
Associated with HTLV-1 |
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Definition
Adult T-Cell Lymphoma
Punched out lytic lesions on bone
with RASH |
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Term
M spike on serum protein electrophoresis
Rouleaux formation of RBC |
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Definition
Multiple myeloma
M spike due to extra gamma globulins present because of increased Ig production
Rouleaux formation where RBC stack like chips due to decreased charge between RBCs |
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Term
| Large B cells with multilobed nuclei and prominent nucleoli |
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Definition
Hodgkin's lymphoma
"owl eyed nuclei" |
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Term
t(9;22)
Increased basophilia |
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Definition
Chronic myelogenous leukemia
BCR-ABL (Philadelphia chr)
Can proceed to acute blast crisis (AML/ALL) |
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Term
Blurry vision
Increased risk for venous thrombosis
Flushed face
Itchyness after bath |
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Definition
Polycythemia vera
Due to hyperviscocity of blood
Associated with JAK2 kinase mutation
Tx: phlebotomy |
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Term
Proliferation of platelets
JAK2 kinase mutation
No significant hyperuricemia/gout |
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Definition
Essential thrombocytosis
Symptoms of bleeding/thrombosis |
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Term
Megakaryocytes produce excess platelet derived growth factor (PDGR) causing marrow fibrosis
Tear Drop Cells |
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Definition
Myelofibrosis
Causes extramedullary hematopoiesis |
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Term
Birbeck granules on EM.
Defective disorder of a dendritic cell type from monocyte lineage |
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Definition
Langerhans cell histiocytoses
dendritic cells of the skin! |
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Term
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Definition
Burkitt's Lymphoma
C-myc oncogene activation |
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Term
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Definition
Follicular lymphomas
bcl-2 over-activation
(bcl-2 normally prevents apoptosis by stabilizing the mitochondrial membrane from releasing cytochrome c)
Most indolent lymphoma (regression and reoccurence) |
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Term
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Definition
M3 type of AML (auer rods)
Auer rods stain peroxidase positive
Responsive to all trans retinoic acid |
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Term
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Definition
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Term
t(11;14)
Painless lymphadenopathy |
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Definition
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Term
| Drug used to boost granulocyte production during times of leukopenia |
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Definition
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Term
| White blood cell tumor associated with eosinphilia |
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Definition
Hodgkin's Lymphoma
Reed sternberg cells secrete inflammatory cytokines to recruit cells, including IL-5 |
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Term
| Bacterial infection that produces lymphocytosis promoting factor |
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Definition
Bordetella Pertussis
Prevents lymphocytes from leaving blood to enter lymph node |
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Term
Lymphocitis leukocytosis with reactive CD8 T cells
Causes generalized lymphadenopathy due to T cell hyperplasia in paracortex of lymph nodes
Splenomegaly due to T cell hyperplasia in periarterial lymphatic sheath |
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Definition
Infectious Mononucleosis:
Epstein Barr Virus
Also CMV sometimes... |
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Term
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Definition
Risk of splenic rupture
Avoid contact sports/activities for 1 year |
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Term
| Acute lymphoblastic leukemia (ALL) hallmark marker for identification |
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Definition
| TdT, a DNA polymerase only present in immature lymphoblasts |
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Term
| Most commonly arises in children, associated with Down Syndrome (>5 years old) |
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Definition
| Acute Lymphoblastic Leukemia (ALL) |
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Term
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Definition
B-cell Acute Lymphoblastic Leukemia (B-ALL)
with t(9;22), has poorer prognosis |
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Term
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Definition
T-cell Acute Lymphoblastic Leukemia/Lymphoma (T-ALL)
Can be lymphoma because it can go into lymph nodes |
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Term
| Myeloblasts usually characterized by positive staining for |
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Definition
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Term
Treatment is with all-trans-retinoic acid (ATRA)
Auer Rods |
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Definition
Acute Myeloid leukemia:
Acute Promyelocytic Leukemia (APL) |
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Term
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Definition
Acute Myeloid leukemia:
Acute Promyelocytic Leukemia
A translocation of the retinoid acid receptor on chromosome 17 |
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Term
| Proliferation of monoblasts, usually in the gums |
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Definition
Acute Myeloid leukemia:
Acute Monocytic leukemia |
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Term
Proliferation of platelet precursor cells
Lacks MPO
Common in Downs Syndrome (<5 years old) |
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Definition
Acute Myeloid leukemia:
Acute megaloblastic leukemia |
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Term
Proliferation of naive B cells with CD5 and CD20
Smudge cells seen on blood smear
Often asymptomatic |
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Definition
| Chronic Lymphocytic leukemia/small lymphocytic lymphoma |
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Term
Hypoagammaglobulinemia
Autoimmune hemolytic anemia
Transforms to large B cell lymphoma |
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Definition
Chronic Lymphocytic Leukemia
Infection most common cause of death due to no Ig production |
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Term
| Neoplastic B cells with filamentous thin projections |
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Definition
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Term
Cells positive for tartrate-resistant acid phosphatase (TRAP)
Cells within red pulp, and bone marrow is fibrosed (dry tap) |
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Definition
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Term
Punched out lytic lesions on bone
with RASH |
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Definition
Adult T-cell leukemia/lymphoma
Associated with HTLV-1
(human t lymphotrophic virus 1) |
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Term
Proliferation of mature CD4 Tcells
Pautrier microabscesses (neoplastic cells in epidermis) |
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Definition
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Term
| Lymphocyes seen with cerebriform nuclei (looks like brain lobules) called Sezary cells |
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Definition
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Term
BCR-ABL
Can proceed to acute blast crisis (AML/ALL) |
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Definition
Chronic Myelogenous Leukemia (CML)
Philadelphia chromosome
t(9;22)
Basophilia |
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Term
| First line treatment of t(9;22) CML |
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Definition
Imatinib
Blocks tyrosine kinase activity |
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Term
| Distinguishing Polycythemia vera vs reactive polycythemia (ie. due to hypoxia) |
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Definition
PV: has normal EPO and normal SaO2
Reactive Polycthemia: Elevated EPO and low SaO2. May also be from renal cell carcinoma with ectopic EPO production
Treatment for PV: phlebotomy |
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Term
Bcl-2 involved with this lymphoma
Most indolent lymphoma (regression and reoccurence) |
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Definition
Follicular lymphoma
t(14;18)
Bcl-2 stabilizes mitochondria, doesn't allow apoptosis |
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Term
| How to distinguish Follicular lymphoma from reactive follicular hyperplasia (infection) |
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Definition
Disruption of normal lymph node architecture
Lack of tingible body macrophages in germinal centers
Bcl-2 expression
Monoclonality of Follicular lymphoma |
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Term
Types of Burkitt Lymphoma
t(8;14) |
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Definition
Endemic - african form get lymphoma in jaw
Sporadic - involves the abdomen |
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Term
Most common type of Hodgkin lymphoma.
Prognostic factors are... |
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Definition
Nodular sclerosis
enlarging vervical or mediastinal lymph node in a young adult female
Better prognosis with high lymphocyte count |
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Term
Hypercalcemia
Bone pain
Lytic bone lesions
Bence jones proteins
AL amyloid |
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Definition
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Term
Birbeck (tennis racket) granules on microscopy
proliferation of specialized dendritic cells |
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Definition
Langerhans cell histiocytosis:
Letterer-siwe disease (malignant, kids younger than 2)
Eosinophilic granuloma (bone fractures)
hand-schuller-christian disease (malignant, kids older than 3) |
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