Term
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Definition
Myeloblast
(Earliest stage RBC. Found in myeloblastic leukemia.)
4:1 N-C
Can see 2 nucleoli |
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Term
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Definition
Promyelocyte (Larger than myelocyte. Coarse granules)
3:1 N-C |
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Term
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Definition
Myelocyte (Round or oval. May see goli body which is white clearing outside of nucleus)
2:1 N-C |
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Term
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Definition
Metamyelocyte (Kidney bean shaped nucleus)
1.5:1 N-C |
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Term
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Definition
Neutrophilic band (C-shaped)
0-5% in peripheral blood |
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Term
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Definition
| Neutrophil (Segmented nucleus) Most common wbc in peripheral blood (50-70%) |
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Term
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Definition
| Lymphocyte (Dark nucleus) 20-40% of cells in the peripheral |
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Term
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Definition
| Reactive lymphocyte (Has irregularly shaped huge cytoplasm. Darker than monocyte. Irregular elongated and occasionally round nucleus) Seen commonly in viral infections and organ transplantation |
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Term
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Definition
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Term
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Definition
Monocyte (Round, horshoe or kidney shaped nucleus. Lacy chromatin compared to dense reactive lymph chromatin. Fine granules in cytoplasm giving the appearance of ground glass)
3-11% of peripheral blood cells |
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Term
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Definition
Eosinophil (Red cytoplasm) 0-5% of peripheral blood
Seen in allergic and parasitic reactions |
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Term
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Definition
| Basophil (Purple/dark blue lumps in a circular shape) 0-1% of peripheral blood |
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Term
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Definition
| Toxic Granulation (Dark granules in cytoplasm of WBC) Seen in patients with bacterial infections, sepsis |
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Term
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Definition
Dohle Bodies (Small RNA clump in the cytoplasm of a granulocyte. Often seen with toxic granulation)
Associated with bacterial infection, pregnancy and sepsis |
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Term
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Definition
Reticulocyte (Immature RBC. May have polychromasia or blue RNA clumps)
Released into the peripheral blood in diseases in which the mature rbc count is low. Seen in haemolytic anemia. |
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Term
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Definition
Nucleated red blood cell (Look similar to lymphocyte)
May be seen in thalassemias, uremia, sepsis, liver diease, sickle cell, post splenectomy and hemolytic anemia |
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Term
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Definition
Basophilic stippling (RNA deposits in the cell cytoplasm)
Associated with lead poisoning, thalassemia |
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Term
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Definition
Siderotic granules (Iron deposits in a cluster in the rbc cytoplasm)
Associated with splenectomy, hemolytic anemia and sideroblastic anemia |
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Term
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Definition
Howell-Jolly Bodies (DNA spot in the rbc cytoplasm)
Associated with splenectomy, hemolytic anemia and megaloblastic anemia |
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Term
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Definition
Cabot rings (Remnants of mitotic spindle in the cytoplasm. Look like rings)
Associated with myelodysplatic syndrome and megaloblastic anemia |
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Term
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Definition
Microcytes (Small rbcs)
Associated with iron deficiency, thalassemias, b12 deficiency |
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Term
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Definition
Macrocytes (Large rbcs)
Associated with newborns, liver diease, chronic alcoholism, vitamin b12 deficiency, folate deficiency and myelodysplastic |
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Term
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Definition
Hypochromia (RBC lacking hemoglobin)
Associated with |
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Term
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Definition
| Polychromia (RBC's that retained some RNA and appear grayish blue) |
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Term
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Definition
Echinocyte (Spikey rbc's)
Associated with uremia and pyruvate kinase deficiency |
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Term
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Definition
Spherocyte (Round with no central pallor zone)
Associated with hereditary spherocytosis, some hemolytic anemias and transfused cells |
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Term
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Definition
Schistocyte (Fragmented rbc's)
Associated with microangiopathic hemolytic anemia |
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Term
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Definition
Codocyte (Cell shaped like a target)
Associated with hemoglobinopathies, thalassemia, iron deficiency anemia and splenectomy |
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Term
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Definition
Drepanocyte (Sickle-shaped cell)
Associated with sickle cell diseases and sometimes hemoglobin SC |
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Term
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Definition
Elliptocyte/Ovalcyte (Cigar shaped and oval shaped rbc's)
Associated with hereditary elliptocytosis or ovalocytosis, thalassemia major, iron deficiency |
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Term
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Definition
Dacryocyte (Tear drop shaped rbc's)
Associated with thalassemia and vitamin B12 deficiency and iron deficiency |
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Term
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Definition
Stomatocytes (Rbc's with slitlike areas of central pallor
Associated with hereditary stomatocytosis and liver disease |
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Term
| Iron deficiency anemia (WBC) |
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Definition
| WBC count is normal with normal range of Segs and lymphs. Normal monocytes |
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Term
| Iron deficiency anemia (RBC) |
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Definition
Hypochromia (2-4+)
Elliptocytes
Schistocytes
Dacrocytes
Microcytosis (2-3+) |
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Term
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Definition
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Term
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Definition
Normal neutrophils
Normal lymphs
Bands increased |
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Term
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Definition
Microcytosis
Hypochromia
Basophilic stippling |
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Term
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Definition
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Term
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Definition
Normal segs
Normal lymphs
Normal monocytes
Reactive lymphs |
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Term
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Definition
Hypochromia (1-3+)
Mircocytosis (2+)
Target cells
Schistocytes
Elliptocytes
Dacrocytes
Basophilic stippling
polychromasia |
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Term
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Definition
| Iron, ferritin levels, CBC |
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Term
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Definition
Normal segs
Normal lymphs
Normal monocytes |
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Term
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Definition
Microcytosis
Elliptocytes
Codocytes
Nucleated red blood cells |
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Term
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Definition
| Iron, Ferritin levels, CBC |
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Term
| Hereditary Spherocytosis (WBC) |
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Definition
Normal neutrophils
Normal lymphs
Normal monocytes |
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Term
| Hereditary Spherocytosis (RBC) |
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Definition
Spherocytes
Polychromasia
Nucleated red blood cells |
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Term
| Hereditary Spherocytosis tests |
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Definition
| Reticulocyte count, physical examination, CBC |
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Term
| Hereditary Elliptocytosis/Ovalocytosis (WBC) |
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Definition
Normal segs
Normal lymphs
Normal monos |
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Term
| Hereditary Elliptocytosis/Ovalocytosis (RBC) |
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Definition
Elliptocytes
Schistocytes
Normochromic
Normocytic |
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Term
| Hereditary Elliptocytosis/Ovalocytosis tests |
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Definition
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Term
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Definition
Increased lymphs
Normal segs
Increased monos
Increased platelets |
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Term
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Definition
Target cells
Elliptocytes
Siderocytes
Howell-Jolly Bodies, Heinz Bodies |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Hypochromia
Echinocytes
Dacryocytes
Cabot rings
Plasmodium falciparum |
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Term
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Definition
| Indirect Fluorescent Antibody Test, Microscopy test |
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Term
| Vitamin B12 Deficiency (WBC) |
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Definition
Increased lymphs
Normal monos
Monocytes
Hypersegmented segs |
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Term
| Vitamin B12 Deficiency (RBC) |
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Definition
Macrocytes (3+)
Elliptocytes (1+)
Microcytes
Dacryocytes
Stomatocytes
Echinocytes
Hypochromia |
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Term
| Vitamin B12 Deficiency tests |
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Definition
| Water-sucrose test, Ham test |
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Term
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Definition
Normal segs
Normal lymphs
Normal monos |
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Term
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Definition
Target cells
Spherocytes
Hypochromia
Microcytes
Macrocytes |
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Term
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Definition
| Urine tests, Serum potassium, blood tests |
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Term
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Definition
Normal lymphs
Normal segs
Normal monos |
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Term
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Definition
Megaloblasts
Drepanocytes
Macrocytes
Target cells
Sphereocytes |
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Term
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Definition
| Water-sucrose test, Ham test |
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Term
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Definition
Hypersegmented neutrophils
Oval macrocytes
Associated with vitamin B12 deficiency, folate deficiency and myelodysplatic syndrome |
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Term
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Definition
Hyposegmented neutrophils (look like peanuts)
Associated with malignancy |
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Term
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Definition
| Thrombocytopenia with large platelts and large basophilic inclusions resembling Dohle bodies in granulocytes and monocytes with the absence of toxic granulation |
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Term
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Definition
| Granulocytes will have large gray-blue granules in the cytoplasm. Lymhs, monos and eos will have large red-purple granules |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Hemoglobin SC (Has crystals that look like schistocytes) |
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Term
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Definition
| CBC, Peripheral blood smear, hemoglobin electophoresis and blood hemoglobin |
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Term
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Definition
| Osmotic fragility, serum iron test |
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Term
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Definition
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Term
| AML1 (AML without maturation) |
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Definition
Mostly myeloblasts
Auer rods |
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Term
| AML 2 (AML with maturation) |
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Definition
Myeloblasts
Promyelocytes
Myelocytes
Metamyelocytes
Auer Rods |
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Term
| AML 3 (APL) (Acute promyelocytic leukemia) |
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Definition
Myeloblasts
Hypergranulated promyelocytes
Schistocytes
Bundles of Auer rods (faggot cells) |
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Term
| AML 4 (AMML) (Acute myelomonocytic leukemia) |
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Definition
Myeloblasts
Promyelocytes
Monoblasts
Promonocytes
Monocytes |
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Term
| AML 5 (Acute monoblastic and monocytic leukemia) |
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Definition
Mainly monoblasts and promonocytes
Moncytes
Myeloblasts
Promyelocytes |
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Term
| AML 6a (Erythroid/myeloid) (Acute erythroid leukemia) |
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Definition
Mainly myeloblasts and erythroid precursors
Oval macrocytes
Microcytes
Basophilic stippling |
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Term
| AML 6b (Pure erythroid leukemia) (Acute erythroid leukemia) |
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Definition
Mainly erythroid precursors
Oval macrocytes
basophilic stippling |
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Term
| AML 7 (Acute megakaryocytic leukemia) |
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Definition
Mainly megakaryoblasts
Atypical platelets
Hypogranular neutrophils |
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Term
| CML (Chronic myelogenous leukemia) |
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Definition
Mainly myelocytes and neutrophils
Myeloblasts (<5%)
Promyelocytes
Metamyelocytes
Bands
Monocytes
Basophil
Eosinophil
Echinocytes |
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Term
| Tests associated with AML 1 |
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Definition
Myeloperoxidase- Pos
Sudan Black B- Pos
Nonspecific esterase- Neg |
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Term
| Tests associated with AML 2 |
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Definition
Myeloperoxidase- Pos
Sudan Black B- Pos |
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Term
| Tests associated with AML 3 (APL) |
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Definition
Myeloperoxidase- Strongly Pos
Sudan Black B- Strongly Pos |
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Term
| Tests associated with AML 4 (AMML) |
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Definition
Myeloperoxidase- Pos
Specific Esterase- Napthol-AS-D chloroacetate esterase Pos in granulocytic cells and weak in monocytic cells |
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Term
| Tests associated with AML 5 |
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Definition
Myeloperoxidase- Neg
Nonspecific esterase- Pos |
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Term
| Tests associated with AML 6a |
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Definition
Myeloperoxidase- Pos
Sudan Black B- Pos
Periodic Acid-Schiff- Block Positivity in erythroblasts
Iron stain: Positive or Negative for Ringed Sideroblasts |
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Term
| Tests associated with AML 6b |
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Definition
Myeloperoxidase- Pos
Sudan Black B- Pos
Periodic Acid-Schiff- Block Positivity in erythroblasts
Iron stain: Positive or Negative for Ringed Sideroblasts
Nonspecific esterase: Pos or Neg |
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Term
| Tests associated with AML 7 |
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Definition
Myeloperoxidase: Neg
Sudan Black B: Neg
Nonspecific esterse: focal positivity
Specific esterase: Neg
Periodic Acid-Schiff: Pos or Neg |
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Term
| Tests associated with CML |
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Definition
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Term
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Definition
Increased neutrophils with few metamyelocytes and rare myelocytes
Promyelocytes and myeloblasts extremely rare
Eosinophils possible
Basophils possible |
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