Term
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Definition
Abnormally low platelet cout
Most common cause of abnormal bleeding
Platelet count < 50,000 / uL
Spontaneous bleeding into skin, mucous membranes, and brain causes intracranial hemorrhage when platelets < 10,000/uL |
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Term
| Spontaneous bleeding into skin, mucous membranes, and brain causes intracranial hemorrhage when platelets reach what level? |
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Definition
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Term
| Idiopathic Thrombocytopenic Purpa (ITP) |
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Definition
| Bleeding caused by a decreased number of platelets by an unknown cause. |
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Term
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Definition
| is unknown, with most evidence pointing to platelet antibodies. Thought to be a result of immune destruction of platelets. |
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Term
| What are the two types of ITP? |
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Definition
| Acute ITP and Chronic ITP |
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Term
| What type of ITP is found in adults? |
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Definition
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Term
| What type of ITP afects women more than men? |
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Definition
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Term
| What type of ITP presents with a history of petechiae, epistaxis (hemorrhage from the nose), abnormal bleeding, and recent viral infection? |
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Definition
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Term
| What type of ITP has a platelet count of 30,000 - 80,000? |
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Definition
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Term
| What type of ITP has a duration of months to years? |
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Definition
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Term
| What type of ITP is treated with corticosteroids or splenectomy? |
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Definition
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Term
| What type of ITP is found in children? |
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Definition
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Term
| What type of ITP occurs the same ammount in both males and females? |
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Definition
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Term
| What type of ITP has an abrupt onset? |
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Definition
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Term
| What type of ITP has 50% of cases occur after viral infection, usually in the winter or spring? |
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Definition
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Term
| What type of ITP has a platelet count of > 20,000? |
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Definition
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Term
| What type of ITP has a durration of 2-6 weeks? |
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Definition
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Term
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Definition
| Abnormally high platelet count, can cause strokes due to platelet clots. |
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Term
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Definition
| Marked and persistent elevation in platelet count and impaired platelet function. Seen in chronic myeloproliferative disorders. Has the highest platelet count, values can exceed 1 million. |
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Term
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Definition
| Platelet function is normal, although increased platelet levels may last for days to weeks. |
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Term
| What are the causes of Secondary (reactive) Thrombocytosis? |
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Definition
- Acute and chronic blood loss
- Chronic inflammatory diseases, such as RA
- Splenectomy
- Rebound thrombocytosis in recovering alcoholics or patients on chemotherapy.
- Iron deficiency anemia
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Term
| What disease causes a decrease or abnormality in factor VII:vWf (von Willebrand Factor) resulting in defect in platelet adhesion? |
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Definition
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Term
| In which disease would you find prolonged bleeding time, a platelet count that is normal - slightly elevated, PT test is normal, and APTT test may be normal? |
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Definition
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Term
| What are the two major causes of coagulation factor disorders? |
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Definition
| A defect in the synthesis of the factor (leads to decreased concentration), and synthesis of a defective factor (leads to abnormal amounts of an inactive or abnormally functioning factor). |
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Term
| What are the two treatments for Coagulation Factor Disorders? |
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Definition
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Term
| Appropriate levels of this Factor are necessary to maintain hemostasis, and cause platelets to aggregate. |
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Definition
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Term
| Whate are two hereditary deficiencies of Factor I |
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Definition
| Hypofibrinogenemia and dysfibinogenemia |
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Term
| What are four acquired deficiencies of Factor I? |
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Definition
| Impared production, excess utilization, Fibrinogen destruction (liver disease or DIC), and complication of surgery. |
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Term
| How are Factor I deficiencies treated? |
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Definition
| with cryoprecipitate and FFP |
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Term
| What is the name for the group of disorders in which a particular clotting factor is decreased. |
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Definition
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Term
| With 13 clotting factors there are a wide range of hemophilias, however, only two disorders are referred to by the name "hemophilia". What are the names of these two disorders? |
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Definition
| Hemophilia A, and Hemophilia B |
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Term
| True or False? Both hemophilias are sex-linked recessive disorders. |
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Definition
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Term
| This Factor deficiency is a deficiency or dysfunction of procoagulant portion (VIII:C) of the factor VIII molecule. |
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Definition
| Factor VIII deficiency (Hemophilia A) |
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Term
| This Factor deficiency is inherited as a sex-linked, recessive trait with bleeding that occurs in the gastrointestinal tract, renal tract, nose, joints, muscles, and after dental extraction. |
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Definition
| Factor VIII deficiency (Hemophilia A) |
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Term
| The most frequent cause of death for patients with Factor VIII deficiency (Hemophilia A) is ______________. |
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Definition
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Term
| Severe hemophilia has less than ____% factor VIII:C activity. |
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Definition
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Term
| Moderate hemophilia has ___ to ___ % factor VIII:C activity. |
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Definition
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Term
| In Hemophilia A, what are the test results for platelet cout, bleeding time, PT, and APTT? |
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Definition
Platelet count - Normal
Bleeding Time - Normal
PT - Normal
APTT - Prolonged |
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Term
| What is the treatment for Hemophilia B, Factor IX deficiency? |
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Definition
| FFP, Factor IX complex, Factor IX concentrates. |
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Term
| What are two other names for Factor IX deficiency? |
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Definition
| Hemophilia B, and Christmas Disease |
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Term
| In Hemophilia B, what are the test results for platelet count, bleeding time, PT, and APTT? |
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Definition
Platelet count - Normal
Bleeding Time - Normal
PT - Normal
APTT - Prolonged |
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Term
| This factor deficiency is a congenital deficiency. Patients show a varying degree of bleeding and bruising. Acquired deficiencies associated with DIC, Liver Disease, and Acute Lukemia. Treated with FFP. |
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Definition
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Term
| This Factor Deficiency is an acquired deficiency stemming from Liver disease, vitamin K deficiency, coumadin. Rare. Symptoms are similar to Hemophilia. Has prolonged PT & APTT. |
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Definition
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Term
| This factor deficiency is a congenital deficiency with less severe bleeding than hemophilia A and spontaneous hemorrhage is rare. Has Normal PT with prolonged APTT. |
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Definition
| Factor XI D Deficiency (Hemophilia C-Rosenthal Syndrome) |
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Term
| This factor deficiency has the following symptoms; Hemorrhage following surgery or trauma, intravascular bleeding, easy bruising, and possible bleeding into the central nervous system. Screening test using urea (all other routine coagulation lab testing is normal) |
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Definition
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Term
| Lab Results for Factor 1 Deficiency |
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Definition
PT|APTT|Thrombin Time|Bleeding Time
PPP- |
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Term
| Lab results for Factor VIII Deficiency (Hemophilia A) |
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Definition
PT|APTT|Thrombin Time|Bleeding Time
NPNN |
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Term
| Lab results for Factor IX Deficiency (Hemophilia B) |
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Definition
PT|APTT|Thrombin Time|Bleeding Time
NPNN |
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Term
| Lab results for Factor V Deficiency |
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Definition
PT|APTT|Thrombin Time|Bleeding Time
PPN- |
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Term
| Lab results for Factor X Deficiency |
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Definition
PT|APTT|Thrombin Time|Bleeding Time
PPN- |
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Term
| Lab results for Factor XI D Deficiency |
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Definition
PT|APTT|Thrombin Time|Bleeding Time
NPN- |
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Term
| This is the most frequently occuring inhibitor, it interferes with the phospholipids portion of the complex which converts prothrombin to thrombin. |
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Definition
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Term
| This inhibitor can be found in 10% of Systemic Lupus Erythematosus patients, patients with autoimmune disorders, drug therapy or viral infections, and in some normal healthy patients. |
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Definition
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Term
| What are the lab results for Lupus Inhibitor? |
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Definition
PT - Slightly prolonged or normal
APTT - Prolonged |
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Term
| This disease is treated by administering vitamin K or antifibinolytic agents, transfusion of FFP |
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Definition
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Term
| This disease causes a variety of hemostatic defects, multiple Factor abnormalities (Increased VIII), abnormal fibinolysis, and platelet disorders. |
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Definition
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Term
| This fibinolytic system disorder is charachterized by purpa, generalized bleeding, and shock. |
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Definition
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Term
| These are described as large platelets that are larger in size than a normal RBC. |
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Definition
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