MAP

SBP + 2(DBP)

3

HR * SV

• Preload
• Afterload
• Contractility 

CO

BSA

NE

• treat
• Action
• AE

• Septic shock
• Vasoconstriction 
• Reflex ↓ HR, ↑ O₂ demand

PE

• treat
• Action
• AE

EP

• treat
• Action
• AE

•  
•  Vasoconstriction, ↑ HR
• Lactic acidosis, 

DA

• treat
• Action
• AE

•  
• Vasodilation, ↑ renal BF, ↑ HR
• ↑ afterload & preload, pulmonary congestion

Vasopressin

• treat
• Action
• AE

•  Vasopressor dose maxed out (adjunct)
•  Vasoconstriction, ↓ urine output  
• ↓ CO, 

DOB

• treat
• Action
• AE

•  Low CO, cardiogenic shock, high LVEDP
• Vasodilation, ↑ CO
• Arrhythmias, ↑ O₂ demand
  

Milrinone

• treat
• Action
• AE

•  
• Vasodilation, ↑ HR
• ↑ O2 demand, arrhythmia, thrombocytopenia

• MAP >65
• SBP >90
• CI >2.2
• SCVO₂ >70%

• T >100.9 or <96.8
• HR >90
• RR >20
• WBC >12K or <4K or >10% bands

• CI 2.2
• PCWP 18

• Dobutamine: β1, β2 agonist
• Milrinone: PDE3 inhibitor

• Fluids

• Hetastarch

α1 receptors

• Where
• Role

• Veins & Arteries
• Constriction: ↑SVR, MAP

β1 receptors

• Where
• Role

• SA node, AV node
• Contractility: ↑CO, HR

β2

• Where
• Role

• Veins & Arteries
• Vasodilation: ↓SVR

• Susceptability
• Spectrum of activity
• SE profile

• CVP >6
• CI >2.2
• MAP >65
• SCVo₂ >70%

• CI >2.2
• PCWP <18
• MAP >65
• Urine output >0.5ml/kg/hr