Term
| mesoblastic phase of hematopoiesis |
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Definition
3rd ---> 9th week of gestation
blood islands from mesoderm of yolk sac
primitive blood vessel formation
primitive erythroblasts |
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Term
| hepatic phase of hematopoiesis |
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Definition
4th week -----> birth
migration of primitive erythroblasts from yolk sac to liver
definitive erythropoiesis (spleen, liver, thymus) |
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Term
| myeloid phase of hematopoiesis |
|
Definition
4th ----> 5th month of gestation
medullary (myeloid) hematopoiesis with early skeletal development |
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Term
|
Definition
found between trabeculae of spongy bone
loose connective tissue composed of 2 compartments:
1. hematopoietic
2. vascular |
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Term
| bone marrow - hematopoietic compartment |
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Definition
has hematopoietic cords of maturing blood cells
supportive stroma (reticular cells, macs)
once matured, blood cells move from the hematopoietic cords to adjacent sinusoids (where they cross endothelial lining to reach circulation) |
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Term
| bone marrow - vascular compartment |
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Definition
consists of....
nutrient artery
arterioles
sinusoids
central longitudinal vein |
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Term
|
Definition
erythropoietin - simulates proerythroblasts; produced in kidney; renal insufficiency = anemia
granulopoietin
thrombopoietin |
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Term
|
Definition
RBC formation - 3-7 days
pronormoblast (proerythroblast)
basophilic normoblast
polychromatophilic normoblast
orthochromatic normoblast
reticulocyte
erythrocyte |
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Term
|
Definition
nucleus gradually condenses, becomes expelled
basophilic ribosomes (like bases, thus stain blue) --------> acidophilic (hemoglobin) cytoplasm
gradual decrease in cell size
nucleus expelled before becoming a reticulocyte (at orthochromatic normoblast stage) |
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Term
|
Definition
MPMMBS
Myeloblast
Promyelocyte (primary granules appear)
Myelocyte (secondary/specific granules appear)
Metamyelocyte
Banded Neutrophil
Segmented Neutrophil
**nucleus gradually condenses
**appearance of primary (azurophilic) granules
**appearance of secondary (specific) granules |
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Term
|
Definition
macrophage in the middle of maturing RBCs
eats what orthochromatin normoblast leaves behind (nucleus) |
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Term
|
Definition
first appearance of neutrophilic (secondary/specific) granules
happens at myelocyte stage |
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Term
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Definition
process of forming monocytes and lymphocytes
**no use of granules!**
nucleus gradually condenses
appearance of few primary (azurophilic granules) |
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Term
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Definition
megakaryoglasts (1 large nucleus with many nucleoli)
keeps duplicating DNA --> becomes polyploid
found adjacent to endothelium of marrow sinusoids
cytoplasmic processes extend through sinus wall to release PLATELETS |
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Term
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Definition
Neutrophils 50-70%
Basophils 0.5%
Eosinophils (1-4%)
Lymphocytes (20-40%)
Monocytes (2-8%) |
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Term
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Definition
| too many myelocytes (immature leukocytes) |
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Term
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Definition
increased # of aged cells
hypersegmented neutrophils |
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