Term
| acute inflammation classic signs |
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Definition
heat (vascular dilation)
Redness (vascular dilation)
Swelling (exudate)
Pain
Loss of function |
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Term
| acute inflammation consists of |
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Definition
vsodilatio
increased permeability of vessels
leukocyte margination (diapedesis)
phagocytosis |
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Term
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Definition
low protein (mostly albumin) ultrafiltrate of blood plasma
it is a fluid
results from hydrostatic alterations aross vascular wall |
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Term
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Definition
escape of fluids
proteins and cells from vascular channels leave vessels
inflammatory response |
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Term
| accumulation of a transudate (non-inflammatory) or an exudate (inflammatory) = |
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Definition
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Term
| hallmark of acute inflammation |
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Definition
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Term
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Definition
2nd week and beyond following injury
consists of...
continued recruitment of monocytes
local proliferation of macs, fibroblasts and small blood vessels
influx of lymphocytes, plasma cells and eosinophils |
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Term
| hallmark of chronic inflammation |
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Definition
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Term
| chronic infla simultaneously involves ... |
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Definition
| active inflammation, tissue destruction and tissue repair |
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Term
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Definition
release histamine when activated by initial damage to tissue site
histamine widens spaces btwn endothelial cells of capillaries making them leaky
NOT derived from basophils (even though they have similar structure and function)
NOT present in circulating blood (prominent around smaller blood vessels and epithelia exposed to ext. environment)
surface receptors for IgE |
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Term
| mast cells characterized by |
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Definition
heparin (glycoprotein - metachromatic staining)
histamine and other inflammation mediators (SRS-A) |
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Term
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Definition
50-70% of WBCs = largest percentage
attracted to pathogens and damaged cells/tissues
this activity is called chemotaxis
love opsonized pathogens
have surface receptors for IgG and complement
produce 3 different cytoplasmic granules (azurophilic, neutrophilic/specific, tertiary)
contain abundant glycogen - anaerobic
short lived (3-4 days)
form pus |
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Term
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Definition
derived from circulating monocytes
possess surface receptors for Igs and complement
can be attracted to sites of inflammation
activated macs become large and rounded = epithelioid (look like epithelial cells)
may fuse to create giant multi-nucleated cells (Langhan's cells)
professional APCs |
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Term
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Definition
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Term
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Definition
seen within connective tissues, rarely in circulation
involved in limited phagocytic activity (antigen-antibody complexes only) and in attacking parasites (only worms)
have receptors for IgE (not on neutrophils) and complement
attack larger parasites (worms) by release of granules whole, next to parasite
produce two different types of granules
1. primary nonspecific (lysosome)
2. secondary/specific (hydrolytic enzymes histaminase, major basic [alkaline] protein)
may play role in would healing (regulate ECM) |
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Term
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Definition
have receptors for IgE
fast granule release (hypersensitivity)
respond to T-lymphocyte signals --> slow granule release --> cutaneous hypersensitivity
produce cytoplasmic granules containing...
heparin
histamine
eosinophil chemotaxic factor (ECF-A) |
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Term
| wound healing (4th day and beyond) |
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Definition
repair begins early
necrotic debris phagocytosed
fibroblasts and vascular endothelial cells proliferate at site of injury (3-5 days) ---> granulation tissue |
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Term
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Definition
tissue that was targeted during inflammation
edematous
contactile (myofibroblasts)
end result = scar = fibrocytes, dense collagen/elastic fibers, ECM and few blood vessels |
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Term
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Definition
granulation tissue
primary union (clean incision)
secondary union (large tissue defect) |
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Term
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Definition
eventually granulation tissue is eliminated
tensile strength of tissue increases VERY SLOWLY, may never exceed 70-90% of its original strength
end result = scar = fibrocytes, dense collagen/elastic fibers, ECM and few blood vessels |
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Term
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Definition
| fibrocytes, dense collagen/elastic fibers, ECM and few blood vessels |
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