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Histology Terminology
Cell Structure and Cell Junctions
39
Biology
Post-Graduate
08/12/2010

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Term
Histology
Definition
The study of normal structure
Term
Prokaryote
Definition
Cell WITHOUT defined nucleus and WITHOUT nuclear membrane
Term
Nuclear envelope/membrane
Definition
Encloses the nucleus/genetic material, regulates import/export via nuclear pores
Term
Messenger RNA
Definition
Complementary to DNA (via transcription)
Binds to ribosomes which read it (via translation) to produce proteins
Term
Plasma membrane/plasmalemma
Definition
Separate cell's contents from the external environment
dynamic interface between external/internal
Lipid bilayer
Term
Lipid bilayer
Definition
2 layers of lipid molecules with hydrophillic heads facing external and internal environment and hydrophobic tails facing in toward the core of the bilayer
Term
Integral proteins
Definition
Protein that is permanently attached to bilayer - anchored to bilayer
Span bilayer
Term
Peripheral proteins
Definition
Adhere only temporarily to membrane, do not penetrate hydrophobic core
Term
Endoplasmic Reticulum
Definition
Modification and folding of proteins synthesized on ribosomes, synthesis of some lipids
Term
Golgi apparatus
Definition
Final assembly and glycosylation of proteins and dispatch to their ultimate destination
Term
Cytosol
Definition
the liquid portion of the cell that is not within organelles
Term
Cytoskeleton
Definition
scaffolding/skeleton within the cell
Term
Microtubule
Definition
component of cytoskeleton - involved in mitosis, cytokinesis, and vesicular transport
Term
Intermediate filaments
Definition
'intermediate' because their average diameter was between those of narrower microfilaments (actin) and wider myosin filaments
Term
Microfilaments
Definition
thinnest filaments of the cytoskeleton found in the cytoplasm
Term
Glycocalyx
Definition
carbohydrate-enriched coating that covers the outside of many eukaryotic cells and prokaryotic cells, particularly bacteria.

When on eukaryotic cells the glycocalyx can be a factor used for the recognition of the cell
Term
Glycolipid
Definition
lipids with a carbohydrate attached. Their role is to provide energy and also serve as markers for cellular recognition.
Term
Glycoprotein
Definition
proteins that contain oligosaccharide chains (glycans) covalently attached to polypeptide side-chains
important integral membrane proteins, where they play a role in cell-cell interaction
Term
Histopathology
Definition
study of the change in structure because of disease
Term
Nucleus
Definition
Eukaryotic Cell - contains genetic information
Term
Nucleoplasm
Definition
protoplasm in nucleus - like cytoplasm in the cell
Term
Ribosome
Definition
organelle that makes proteins
Term
Eukayote
Definition
defined nucleus that contains genetic material
Term
Nucleolus
Definition
rRNA is transcibed and assembled here
Term
DNA
Definition
genetic blueprint -found in nucleus
Term
Cytoplasm
Definition
the part of the cell enclosed by the cell membrane EXCLUDING the nucleus
Term
Rough ER
Definition
ER with ribosomes attached
Term
Smooth ER
Definition
Without ribosomes, synthesis lipids and steroids
Term
Secretory granule
Definition
Secretory vesicles become increasingly condensed as they migrate though the cytoplasm to form SECRETORY GRANULES which are then liberated at the cell surface by exocytosis
Term
Mitochondria
Definition
Energy production in the form of ATP
Term
Differentiated Cells
Definition
A cell that has assumed a specialized function
Term
Stem Cells
Definition
Relatively undifferentiated cells that are able to divide and replace the differentiated cell population as required
Term
Endocytosis
Definition
The collective process of a cell taking up particulate matter and large macromolecules
--many different types of endocytosis
Term
Receptor-mediated endocytosis
Definition
Used extensively for the uptake of specific molecules that bind to cell surface receptors
Term
Phagocytosis
Definition
is the cellular process of phagocytes and protists engulfing solid particles by the cell membrane to form an internal phagosome (vacuole)
Term
Cell cycle
Definition
Interphase, Mitotic phase: Prophase, Metaphase, Anaphase, Telophase
Term
Tight Junction
Definition
block the passage of molecules between adjacent cells – cannot penetrate between the lining of cells
Term
Zonula adheren/ Desmosomes
Definition
give the epithelium strength by linking the cytoskeletons of adjacent cells
Term
Gap Junctions
Definition
provide a conduit for the passage of small molecules directly between adjacent cells – allows signaling by the passage of small molecules between adjacent cells to coordinate and synchronies functions of the epithelium
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