Term
| What are described as complexes forming at specific sites of cell membranes |
|
Definition
|
|
Term
| 3 typical components of INTERcellular junctions are what? |
|
Definition
transmembrane ahesive protein
cytoplasmic adapter protein
cytoskeletal filament |
|
|
Term
| What INTERcellular junction arrangement is described as a patch-like junction of limited extent? |
|
Definition
|
|
Term
| What INTERcellular junction arrangement is described as a junction which encircles the entire cell? |
|
Definition
|
|
Term
| In INTERcellular junctions where is the junctional complex (terminal bar) located? |
|
Definition
| cuboidal or columnar epithelium |
|
|
Term
| In INTERceullular junctions junctional combinations where is the intercalated disc located? |
|
Definition
|
|
Term
| What is a type of communicating junction? |
|
Definition
|
|
Term
| What are some examples of a tight junction |
|
Definition
| occluding junction, zonula occludens |
|
|
Term
| What are some examples of an adhering junction (which is an adhesive junction) |
|
Definition
adherens junction
zonula adherens |
|
|
Term
| In the realm of adhesive junctions, a macula adherens is considered a ? |
|
Definition
|
|
Term
| What are two examples of cells attaching to/anchoring in the extracellular matrix? |
|
Definition
Hemidesmosome
Focal Adhesion |
|
|
Term
| What type of junction is a plaque like junction and has cell membranes of neighboring cells very close together; intercellular space only 2-3 nm |
|
Definition
| Gap-communicating junction |
|
|
Term
| Gap/communicating junction can be found in... |
|
Definition
|
|
Term
| What junction is common in epithelial cells, smooth and cardiac muscle cells, neuronal cells, and osteocytes? |
|
Definition
| Gap-communicating junction |
|
|
Term
| What is the integral membrane protein in gap/communication junctions? |
|
Definition
|
|
Term
| How many connexins form a connexon? |
|
Definition
|
|
Term
| Connexons of one cell connect to connexons in adjacent cell to form ? |
|
Definition
|
|
Term
| What can be passed through gap junctions? |
|
Definition
| Small signaling molecules and ions |
|
|
Term
| In gap junctions connected cells are ? coupled for coordinated responses to stimuli? |
|
Definition
|
|
Term
tight/occluding junctions have ? strands of adhesive transmembrane proteins.
They also have ? series of contacts to proteins of adjacent cell. |
|
Definition
|
|
Term
In what junction is the intercellular space obliterated at contact site?
This type of junction encircles what? |
|
Definition
Tight/occluding junction
entire cell |
|
|
Term
| Tight/occluding junctions are found where? |
|
Definition
| close to apical end of cuboidal or columnar epithelial cells |
|
|
Term
| Tight/occluding junction has Transmembrane proteins: members of ?family (4 pass membrane proteins); also: occludin, junctional adhesive molecule |
|
Definition
|
|
Term
| In tight/occluding junction Some cytoplasmic proteins: ?, transcription factors, cell polarity-related proteins |
|
Definition
|
|
Term
| In tight/occluding junction what filaments are associated? |
|
Definition
|
|
Term
| In tight/occluding junction Movement of ions and small molecules in intercellular space is? |
|
Definition
|
|
Term
| Tightness of occluding junction depends on? |
|
Definition
| number of junctional strands, their completeness, and type of adhesive protein |
|
|
Term
| In tight/occluding junction movment of mem. proteins is |
|
Definition
|
|
Term
| Tight/occluding junction has ... |
|
Definition
|
|
Term
| What junction? Cells held together or attached to / anchored in the extracellular matrix |
|
Definition
|
|
Term
| What junction? Intercellular space between attached cells: 20 nm wide at location of adhesive junction |
|
Definition
|
|
Term
| Adhesive junctions commonly involved in (intra) ? |
|
Definition
| ) cellular signaling (e.g. for nuclear transcription, tumor suppression, differentiation) |
|
|
Term
| In adhesive junctions Loss of contact to adjacent cells or extracellular matrix may trigger |
|
Definition
| apoptosis or result in loss of polarity |
|
|
Term
In adhesive junctions:
Cell-to-cell adhesive junctions:
Transmembrane adhesive proteins members of ? (calcium ion-dependent proteins) family
Cytoplasmic adapter proteins members of the ? family |
|
Definition
|
|
Term
In adhesive junctions:
Cell-to-ECM adhesive junctions:
Similar to cell-to-cell adhesive junctions, but:
Transmembrane proteins members of ? family (heterodimers with alpha and beta subunits |
|
Definition
|
|
Term
What is an Adhesive junction with electron-lucent intercellular space and ‘fuzzy’ plaque on cytoplasmic face
Associated with belt-like band of actin
Encircles entire cell (zonula)
Found basal to tight junction zonula in epithelial cells |
|
Definition
|
|
Term
What junction
Transmembrane adhesive proteins: E-cadherin; (nectin)
Cytoplasmic adapter proteins: - and -catenin; (p120 catenin, afadin, vinculin, -actinin)
Catenins interact with cytoplasmic domain of trans-membrane protein, cytoskeletal proteins, and other cytoplasmic proteins
Cytoskeletal element: actin filaments (continuous with apical terminal web) |
|
Definition
|
|
Term
What junction?
Contribution to adhesive force between one cell and another
Support to apical domain of epithelial cell
Intracellular signaling |
|
Definition
|
|
Term
What junction?
Disk-shaped adhesive junction (macula)
Electron-dense cytoplasmic attachment plaque |
|
Definition
|
|
Term
What junction?
Intercellular space (ca. 30 nm; somewhat wider than in ZA) filled with highly-ordered proteins
Found basal to zonula adherens in epithelial cells in band encircling cell as well as scattered over lateral cell surface
Common in many tissue types |
|
Definition
|
|
Term
| What has Transmembrane adhesive proteins (cadherins): desmoglein, desmocollin |
|
Definition
|
|
Term
| Interaction of cadherins from adjacent cells results in? |
|
Definition
| electron-dense line in intercellular space |
|
|
Term
What has Cytoplasmic adapter proteins (catenins): desmoplakin, plakoglobin, plakophilin
Cytoskeletal element: intermediate filaments (anchoring in catenin plaque); type depends on tissue type |
|
Definition
|
|
Term
What?
Attachment site for strong cytoskeletal components (intermediate filaments)
Provides firm adhesion among cells |
|
Definition
|
|
Term
What does this?
Sheet-like arrangement of extracellular matrix proteins ( ca. 20-100 nm wide)
Binds epithelium to underlying connective tissue
Also found around muscle cells and nerve fibers |
|
Definition
| Basal lamina/basement membrane |
|
|
Term
What does this?
Provides metabolic support
Filters material (barrier function)
Controls epithelial growth and differentiation; prevents downward epithelial growth |
|
Definition
| Basal lamina/ basement membrane |
|
|
Term
The components of the basal lamina/basement membrane are:
Heparan sulfate (glycosamino-glycan)
Collagen type IV
Fibronectin
Laminin
and what 3 things? |
|
Definition
Entactin
Collagen type 3
Collagen type 7 (anchoring fibrils) |
|
|
Term
| what are the layers of the basal lamina/basement membrane (visible only in TEM)??? |
|
Definition
Lamina lucida
Lamina densa
Lamina fibroreticularis |
|
|
Term
What is this?
Plaque-like adhesive junction morphologically similar to a half-desmosome
Forms at the basal side of certain epithelial cells in zone of contact with basal lamina |
|
Definition
|
|
Term
| What are the TME and CSE for Focal Adhesion? |
|
Definition
|
|
Term
| What are the TME and CSE for Focal Adhesion? |
|
Definition
|
|
Term
| What are the TME and CSE for Hemidesmosome? |
|
Definition
TME: integrin
CSE: intermediate filament |
|
|
Term
What is this?
Transmembrane adhesive proteins: integrin (64)
Integrins bind to basal lamina glycoprotein laminin
Cytoplasmic adapter proteins: bulbous pemphigoid antigen 230 (BP230); plectin |
|
Definition
|
|
Term
What is this?
Cytoplasmic proteins form dense plaque
Cytoskeletal element: intermediate filaments (anchoring in plaque) |
|
Definition
|
|
Term
What is this?
Provides tight anchoring of epithelial cell to basal lamina and underlying connective tissue |
|
Definition
|
|
Term
What is this?
Dynamic assembly of many (>50) different proteins
Provides linkage of cell to extracellular matrix
Important for intracellular signaling |
|
Definition
|
|
Term
What is this?
Transmembrane adhesive protein: integrin heterodimers
Cytoplasmic adapter proteins: -actinin, vinculin, talin
Cytoskeletal element: actin filaments
Integrins bind to ECM proteins fibronectin, laminin, collagen |
|
Definition
|
|
Term
| Genetic abnormalities or autoimmune responses of / to transmembrane and cytoplasmic junctional proteins can affect what 3 things? |
|
Definition
function
differentiation
development of cells |
|
|
Term
What is linked to:
: deafness, cataracts, Charcot-Marie-Tooth demyelinating disease, oculodentaldigital dysplasia |
|
Definition
|
|
Term
| What is : linked to mutations of genes for desmosomal, hemidesmosomal, and intermediate filament proteins |
|
Definition
|
|
Term
| What is linked to the auotimmune disease affecting oral mucosa due to production of antibodies to cadherins in desmosomes? |
|
Definition
|
|
