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human physiology
test 1
65
Physiology
Undergraduate 4
09/07/2009

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Term
Physiology
Definition
study of the functions of living things.
Term
what are the two approaches to explaining events that occur in the body
Definition

one: emphasizing the purpose of a body process

two: the underlying mechanism by which this process occurs.

Term
levels of organization in the body in order and give an example of each
Definition
chemical (molecule in the membrane that encloses a cell), cellular (a cell lining the stomach), tissue layers of tissue in the stomach wall), organ (the stomach), body (the digestive system)
Term
Homeostasis
Definition
maintaining the same condition
Term
what are the major organ systems (that we will cover)
Definition

Cardiovascular

Respiratory

Renal

G.I.

Term

Points to know

Cardiovascular system

Definition
circulatory system brings O and CO2 through system (density of capillaries)
Term
Respiratory system
Definition
maintain homeostatis of O and CO2 levels
Term
Renal system
Definition

most significant 1) gets rid of waste

2) conditions the body fluid ----keeping body fluid at the same constant concentration ex. sodium(osmosis is your life)

Term
billirubin
Definition
by product of hemoglobin (if you dont get rid of it can cause mental retardation ---very toxic)
Term
G.I. system
Definition
maintains good level of glucose and low levels of waste
Term
the most common atoms in the body are...
Definition
oxygen, carbon, hydrogen, and nitrogen 96%
Term
lipid bilayer is made up of
Definition
phosholipids
Term
three types of specialized cell junctions
Definition

tight junctions impermeable

gap junctions communicating

desmosomes

Term
desmosomes
Definition

adhesive junctions that do not regulate cell shape

act as "spot rivets" bt two adjacent cells

most abundant in tissue that is subject to stretching

Term
tight junctions
Definition

"staples" together cells and seals off passageways bt the cells

prevents undesirable leaks

found in epithelial tissue

Term
gap junctions
Definition

small connecting tunnels made by connexons

abundant in cardiac and smooth muscle

 

In nonmuscle tissues permits unrestricted passage of small nutrient molecules between cells
serves as a method for a direct transfer of small signaling molecules from one cell to the next
Term
connexon
Definition
a channel bt cells that allows exchange of intercellular fluid  6 form bridge....gap junction
Term
what are the two types of membrane transport
Definition
unassisted and assisted
Term
unassisted transport includes
Definition
diffusion and osmosis
Term
assisted transport
Definition

carrier mediated

facilitated

active

Term
osmosis
Definition
net diffusion of water down its own concentration gradient
Term
membranes are ______ to water but ______ to solute
Definition
permeable...impermeable
Term
isotonic conditions
Definition
no net movement of water no change in cell volume
Term
hypotonic conditions
Definition
water diffuses into cells...they swell
Term
hypertonic conditions
Definition
water diffuses out of cell...they shrink
Term
symport
Definition
an integral membrane protein that simultaneously transports two substances across membrane in the same direction
Term
antiport
Definition
an integral membrane protein that simultaneously transports two substances in the opposite directions
Term
the Na K pump is what kind of transport
Definition
active....uses energy to drive the Na uphill out of the cell
Term
Primary Active Transport in a Na K pump
Definition
establishes Na concentration gradient from lumen to cell which drives Secondary Active Transport
Term
Secondary Active Transport in Na K pump
Definition
create glucose concentration gradient from cell to blood which is used for facilitated diffusion
Term
what substances are involved in diffusion through the lipid bilayer what energy requirements and what is the limit
Definition
nonpolar molecules of any size...passive transport (molecules move from high to low concentration) and will cease when there is equilibrium
Term
what substances are involved in diffusion through protein channels what energy requirements and what is the limit
Definition
specific small molecules (K+ Ca 2+ Cl-) passive high to low concentration by attraction of ion to opp charge will cease when there is equilibrium
Term
what substances are involved in diffusion by osmosis what energy requirements and what is the limit
Definition
water only passive from high to low concentration goes until the concentration diff is abolished or until stopped by opposing hydrostatic pressure or until cell is destroyed
Term
what substances are involved in facilitated diffusion  what energy requirements and what is the limit
Definition
specific polar molecules which carriers are available passive from high to low goes until transport max carrier can become saturated
Term
what substances are involved in primary active transport what energy requirements and what is the limit
Definition
specific cations carriers are available ...active ions move against gradient low to high (requires ATP) goes til the transport max carrier can become saturated
Term
what substances are involved in secondary active transport (symport or antiport) what energy requirements and what is the limit
Definition
specific polar molecules and ions coupled transport carriers are available...active against gradient driven directly by ion gradient (Na+) goes til transport max coupled transport carrier can become saturated
Term
membrane potential
Definition
the voltage difference between the inside and the outside of the cell
Term
Na+ is in high concentration on the _____ of the cell and K+ is in high concentration on the ____ of the cell
Definition
outside...inside
Term
the concentration of Na+ is _____ mM extracellularly and ____mM intracellularly the relativie permeability is _____mM
Definition
150....15....1
Term
the concentration of K+ is _____ mM extracellularly and ____mM intracellularly the relativie permeability is _____mM
Definition
5....150...25-30
Term
the concentration of A- is _____ mM extracellularly and ____mM intracellularly the relativie permeability is _____mM
Definition
0...65...0
Term
resting membrane potential
Definition
-70 mV
Term
Acetylcholine
Definition
A white crystalline derivative of choline, CHNO, that is released at the ends of nerve fibers in the somatic and parasympathetic nervous systems and is involved in the transmission of nerve impulses in the body.
Term
Norepinephrine
Definition
catecholamine with dual roles as a hormone and a neurotransmitter
Term
Epinephrine
Definition
(adrenaline)is a hormone and neurotransmitter[1] that participates in the "fight or flight" response of the sympathetic nervous system.[2] It
Term
Serotonin
Definition
80 to 90 percent of the human body's total serotonin is located in the enterochromaffin cells in the gut, where it is used to regulate intestinal movements.
Term
histamine
Definition
is a biogenic amine involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.[1] Histamine triggers the inflammatory response.
Term
Glycine
Definition
is the organic compound with the formula NH2CH2COOH. With only a hydrogen atom as its side chain, glycine is the smallest of the 20 amino acids commonly found in proteins. Glycine is unique among the proteinogenic amino acids in that it is not chiral.
Term
Glutamate
Definition
It is a non-essential amino acid. The carboxylate anions and salts of glutamic acid are known as glutamates.
Term
aspartate
Definition
The carboxylate anion of aspartic acid is known as aspartate.
Term
aspartate
Definition
The carboxylate anion of aspartic acid is known as aspartate.
Term
Gamma- aminobutyric acid
Definition
is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays an important role in regulating neuronal excitability throughout the nervous system
Term
what are the four types of chemical messengers
Definition

paracrines

neurotransmitters

hormones

neurohormones

Term
paracrines
Definition

local chemical messengers

exert effect only on neighboring cells in immediate environment of secretion site

Term
neurotransmitters
Definition

short range chemical messengers

diffuse across narrow space to act locally on adjoining target cell

Term
hormones
Definition

long range messengers

secreted into blood by endocrine glands in response to appropriate signal

exert effect on target cells some distance away from release site

Term
neurohormones
Definition

hormones released into blood by neurosecretory neurons

distributed through blood to distant target cells

Term
signal transduction
Definition
process by which incoming signals are conveyed to target cells interior
Term
binding of extracellular messenger to matching receptor brings about desired intracellular response by either
Definition

opening or closing channels

activating second messenger systems

Term
endocrinology
Definition
study of homeostatic activities accomplished by hormones
Term
two distinct groups of hormones based on their solubility properties
Definition

hydrophilic hormones---highly water soluble low lipid solubility

 

Lipophilic hormones---high lipid solubility poorly soluble in water

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