Shared Flashcard Set

Details

Immuno B1 L2
n/a
61
Other
Professional
01/10/2010

Additional Other Flashcards

 


 

Cards

Term
a _ stem cell gives rise to immune system cells. it first gives rise to 2 other cells
Definition
pluripotent

common lymphoid progenitor
myeloid progenitor
Term
NK cells share their lineage most closely with what other cell of immune system?
Definition
T cells
Term
common lymphoid progenitor --> ?
Definition
NK
T cells
B cells
Term
common myeloid progenitor --> (6)
Definition
megakaryocyte
RBC
monocyte
eosinophil
basophil
neutrophil
Term
hallmark of HIV infection is decrease in what kind of cells?
Definition
CD4+ T cells
Term
reticuloendothelial system 3 roles
Definition
-phagocytosis
-cytokine production to recruit other inflammatory cells
-peptide antigen presentation
Term
RES includes (5)
Definition
monocytes
macrophages
dendritic cells
Langerhans cells
glial cells
Term
dendritic vs. langerhans cells
--found where?
Definition
lymph nodes
skin
Term
mast cells are the _ counterparts of _
Definition
tissue
basophils
Term
3 phagocytic cells
Definition
monocytes
macrophages
neutrophils
Term
the first cells recruited to inflammatory sites
Definition
neutrophils
Term
3 notable phagocytes
Definition
neutrophils
monocytes
macrophages
Term
_ are phagocytes that are big on chemotaxis
Definition
neutrophils
Term
"professional" antigen presenting cells (3)
Definition
macrophages
dendritic cells
B cells
Term
defense against parasites is by (3)
Definition
eosinophils
basophils
mast cells
Term
eosinophils defend against parasites and participate in _ _ reactions
Definition
cytotoxic hypersensitivity
Term
neutrophils do or don't do antigen presentation?
Definition
don't
Term
basophils/mast cells have receptors for _ antibodies
Definition
IgE
Term
basophils/mast cells have granules that contain (2)
Definition
heparin
histamine
Term
basophils / mast cells degranulate when...
Definition
cell-bound IgE antibodies are cross-linked by antigens
Term
macrophages are differentiated _
Definition
monocytes
Term
_ provide a link between innate and adaptive immunity
Definition
dendritic cells
Term
dendritic cells present antigen to both
Definition
T helper
T cytotoxic cells
Term
B cell class switching from Ig _ to ... is thought to require what cells' assistance?
Definition
IgM --> IgG, IgA, or IgE
T helper cells
Term
every mature T cell expresses the _ molecule, (which is associated with the TCR)
Definition
CD3
Term
~ are the primary regulators of T cell- and B cell- mediated responses
Definition
T helper cells
Term
T helper cells help (2)
Definition
B lymphocytes to become antibody-producing cells

effector T cells in cell-mediated immunity
Term
T helper cells express CD _
Definition
CD4
Term
T helper cells recognize foreign antigen complexed with ~
Definition
MHC Class II
Term
T helper 1 cells aid in ...
T helper 2 cells aid in ...
Definition
regulation of cellular immunity
B cell production of certain classes of antibodies
Term
T cytotoxic cells are cytotoxic against (2)
Definition
tumor cells
cells infected with intracellular pathogens
Term
cytotoxic T cells usu express CD
Definition
8
Term
T cytotoxic cells destroy infected cells in an antigen-specific manner that is dependent upon the expression of ~ molecules on ~ cells
Definition
MHC class I
antigen-presenting
Term
T suppressor cells suppress
Definition
T and B cell responses
Term
T suppressor cells express _ molecules
Definition
CD8
Term
NKT cells are actually _ cells that share properties of both
Definition
T
Term
NKT cells recognize an antigen presenting molecule _ that binds to ...
Definition
CD1d
self- and foreign
lipids and glycolipids
Term
NK cells nonspecifically kill (2)
Definition
tumor cells
virus-infected cells
Term
NK cells are able to kill _ in the absence of _ _ receptors
Definition
self
antigen-specific
Term
_ cells are especially effective against viral infected cells
Definition
NK
Term
NK cells secrete _ _ which is an effective immunoregulator
Definition
interferon gamma
Term
NK cells can kill via ~ using their _ receptors
Definition
ADCC
Fc receptors
Term
antigen presenting cells are found primarily in (4)
Definition
skin, lymph nodes, spleen, thymus
Term
two cells in brain that can do phagocytosis
Definition
astrocytes
microglia
Term
10 antigen presenting cells
Definition
monocytes
macrophages
langerhans cells
dendritic cells
B cells
T cells
astrocytes
thyroid follicular cells
endothelium
fibroblasts
Term
antigen-driven proliferation and differentiation take place in _ lymphoid organs
Definition
secondary
Term
B and T cells differentiate from stem cells in _ lymphoid organs
Definition
Term
T lymphocytes learn to recognize self antigens as self where?
Definition
thymus
Term
only _ % of maturing T lymphocytes survive and leave the thymus
Definition
5-10%
Term
B cells differentiate in the fetal _
Definition
liver
Term
B cells differentiate in the adult _
Definition
bone marrow
Term
major secondary lymphoid organs; (2)
others include (7)
Definition
spleen
lymph nodes

tonsils
appendix
Peyer's patches
MALT
BALT
GALT
bone marrow
Term
lymph nodes have a _ cell cortex and a _ cell paracortex as well as a central medulla
Definition
B cell cortex
T cell paracortex
Term
lymphoid tissue of spleen is in the _ pulp
Definition
white
Term
white pulp of spleen is arranged around a _ _ as a _
Definition
central arteriole
periarteriolar lymphoid sheath PALS
Term
within the PALS (specifically, within its _ _) are (2) which present antigen
Definition
dendritic reticular cells
phagocytic macrophages
Term
monocytes are circulating _ precursor
Definition
macrophage
Term
_ cells are responsible for initiation of adaptive responses
Definition
dendritic
Term
rank from most to least numerous in blood -- monocyte, basophil, neutrophil, eosinophil
Definition
neutrophil
monocyte
eosinophil
basophil
Term
...are responsible for adaptive cell-mediated immunity
Definition
NKT cells
T cells
Term
B cells process and present _ antigens
Definition
protein
Supporting users have an ad free experience!