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Kinetics Final
Kinetics
22
Other
Not Applicable
05/15/2013
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Term

Digoxin

  • Weight
  • Monitor
 Definition
  • IBW
  • Troughs (6-8h)
Term

Digoxin

  • Bioavailability (F)
 Definition
  • Tablet: 0.7
  • Elixer: 0.8
Term

Digoxin

  • Loading dose when
 Definition
  • Non-HF: 50% load, 25% (2X each 6-8h)
  • HF: No loading dose 
Term

Heparin

target PTT

 Definition
  • 46-70
Term

Heparin

  • Loading
 Definition
  • 80 units/kg/h (max 5K) IV
Term

Heparin

  • Maintanance
 Definition
  • 18 units/kg/hr (IV/SQ)
Term

VD

  • Serum
  • ECF
  • Adipose tissue
 Definition
  • 5%
  • 25%
  • 65%
Term
When to use IBW
 Definition
  • VD ~ 0.05 l/Kg
  • Digoxin
Term
When to use Adjusted BW
 Definition
  • VD = 0.25L/kg-0.65L/Kg
Term
When to use Actual BW
 Definition
  • VD > 0.65L/Kg
Term

Define

  • MIC
  • MBC

 

 Definition
  • Inhibit visual growth at 24h
  • Kill 99.9% at 24h (3log10)
Term
Antibiotic efficacy factor
 Definition

Breakpoint

    MIC
Term

Time dependent 

  • Antibiotics
  • Measurement
 Definition
  • Beta Lactams
  • T>MIC 
Term

Concentration dependent

  • Antibiotics
  • Measurement
 Definition
  • Aminoglycosides, Daptomycin, FQ
  • Peak/MIC
Term

Vancomycin

  • VD
  • Which weight?
 Definition
  • 0.7 L/kg
  • Actual
Term
Linear drugs show ___ clearance
 Definition
Long-linear
Term

Estimating Vancomycin frequency

  • Usual Crcl
  • Usual frequency
 Definition
  • 120 ml/min
  • Q12h
Term

Lithium

  • Clearance 
 Definition
  • 25% of CrCl
Term

Lithium

  • Test dose
  • When to measure
 Definition
  • 600mg
  • 24h
Term

Define

  • Vmax
  • Km
 Definition
  • Max rate of elimination
  • 1/2 Vmax
Term

Phenytoin

  • % free
  • S
 Definition
  • 10% free
  • Phenytoin Sodium Capsule S = 0.92
  • 50mg/min
Term

Phenytoin

  • Vmax
  • Km
 Definition
  • 7mg/Kg/day
  • 4mg/L
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