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Krebs Cycle
Medical School Biochemistry
21
Biochemistry
Graduate
10/14/2011

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Cards

Term
The Krebs cycle is involved in the breakdown of what metabolic fuels?
Definition
Carbohydrates, Fats (and Ketone bodies), Proteins
Term
Where in the cell does the Krebs Cycle occur?
Definition
In the mitochondria
Term
How much energy does the Krebs Cycle produce? What is the breakdown?
Definition
36-37 molecules of ATP
Term
What is the first step of the Krebs Cycle?
Definition
Oxaloacetate -> Citrate (tricarboxylic acid)

via Citrate Synthase
Term
What inhibits the enzyme Citrate synthase?
Definition
ATP
Acetyl-CoA
NADH
Citrate
Succinyl CoA
Term
What is the second step of the Krebs Cycle?
Definition
Citrate -> Isocitrate

via: aconitase
Term
What inhibits aconitase?
Definition
Fluoroacetate (rat poison, turns into fluoroacetyl CoA)
Term
What is the third step of the Krebs cycles?
Definition
Isocitrate -> alpha-ketoglutarate

via Isocitrate dehydrogenase
Term
What inhibits Isocitrate dehydrogenase?
Definition
ATP, NADH + H+
Term
What upregulates isocitrate dehydrogenase?
Definition
ADP and Calcium
Term
What is a downstream metabolic consequence of inhibiting isocitrate dehydrogenase?
Definition
Will cause a buildup of Citrate. Citrate inhibits PFK-1 in glycolysis and also stimulates Fatty Acid synthesis
Term
What is the fourth step of the Krebs Cycle?
Definition
alpha-ketoglutarate -> Succinyl coa

via alpha-ketoglutarate dehydrogenase
Term
What inhibits alpha-ketoglutarate dehydrogenase?
Definition
ATP, NADH + H+, and Succinyl CoA
Term
What upregulates alpha-ketoglutarate?
Definition
Calcium
Term
What is the fifth step of the Krebs Cycle?
Definition
Succinyl CoA -> Succinate

Succinyl CoA Synthetase
Term
Besides the Krebs cycle, when else is alpha-ketoglutarate produced?
Definition
In the transamination of glutarate
Term
what upregulates Succinyl CoA synthetase?
Definition
Calcium
Term
In what other metabolic pathways is Succinyl CoA produced?
Definition
In the metabolism of fatty acids and amino acids
Term
What is the sixth step of the Krebs Cycle?
Definition
Succinate -> Fumarate

via Succinate dehydrogenase
Term
What is the seventh step of the Krebs Cycle?
Definition
Fumurate -> Malate

via Fumarase
Term
What is the 8th Step of the Krebs Cycle?
Definition
Malate -> Oxaloacetate

via Malate dehydrogenase
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