Term
The Krebs cycle is involved in the breakdown of what metabolic fuels? |
|
Definition
Carbohydrates, Fats (and Ketone bodies), Proteins |
|
|
Term
Where in the cell does the Krebs Cycle occur? |
|
Definition
|
|
Term
How much energy does the Krebs Cycle produce? What is the breakdown? |
|
Definition
|
|
Term
What is the first step of the Krebs Cycle? |
|
Definition
Oxaloacetate -> Citrate (tricarboxylic acid)
via Citrate Synthase |
|
|
Term
What inhibits the enzyme Citrate synthase? |
|
Definition
ATP Acetyl-CoA NADH Citrate Succinyl CoA |
|
|
Term
What is the second step of the Krebs Cycle? |
|
Definition
Citrate -> Isocitrate
via: aconitase |
|
|
Term
|
Definition
Fluoroacetate (rat poison, turns into fluoroacetyl CoA) |
|
|
Term
What is the third step of the Krebs cycles? |
|
Definition
Isocitrate -> alpha-ketoglutarate
via Isocitrate dehydrogenase |
|
|
Term
What inhibits Isocitrate dehydrogenase? |
|
Definition
|
|
Term
What upregulates isocitrate dehydrogenase? |
|
Definition
|
|
Term
What is a downstream metabolic consequence of inhibiting isocitrate dehydrogenase? |
|
Definition
Will cause a buildup of Citrate. Citrate inhibits PFK-1 in glycolysis and also stimulates Fatty Acid synthesis |
|
|
Term
What is the fourth step of the Krebs Cycle? |
|
Definition
alpha-ketoglutarate -> Succinyl coa
via alpha-ketoglutarate dehydrogenase |
|
|
Term
What inhibits alpha-ketoglutarate dehydrogenase? |
|
Definition
ATP, NADH + H+, and Succinyl CoA |
|
|
Term
What upregulates alpha-ketoglutarate? |
|
Definition
|
|
Term
What is the fifth step of the Krebs Cycle? |
|
Definition
Succinyl CoA -> Succinate
Succinyl CoA Synthetase |
|
|
Term
Besides the Krebs cycle, when else is alpha-ketoglutarate produced? |
|
Definition
In the transamination of glutarate |
|
|
Term
what upregulates Succinyl CoA synthetase? |
|
Definition
|
|
Term
In what other metabolic pathways is Succinyl CoA produced? |
|
Definition
In the metabolism of fatty acids and amino acids |
|
|
Term
What is the sixth step of the Krebs Cycle? |
|
Definition
Succinate -> Fumarate
via Succinate dehydrogenase |
|
|
Term
What is the seventh step of the Krebs Cycle? |
|
Definition
Fumurate -> Malate
via Fumarase |
|
|
Term
What is the 8th Step of the Krebs Cycle? |
|
Definition
Malate -> Oxaloacetate
via Malate dehydrogenase |
|
|