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LA Musculoskeletal
Exam 1 (lectures 1-6)
116
Veterinary Medicine
Graduate
10/06/2012

Additional Veterinary Medicine Flashcards

 


 

Cards

Term
What is the definition of lameness?
Definition
any alteration of the horses gait. in addition, lameness can be manifested in such ways as a change in attitude or performance
Term
What are some important points to consider when taking a history for a lameness exam?
Definition
occupation/performance level, duration, cause, change with exercise, when was the horse last shod, signs, effect of treatments, performance changes
Term
What are you looking for in the "exam from a distance"?
Definition
posture, symmetry, conformation, abnormalities
Term
What % of a horses BW is distributed to the hind and front end?
Definition
front 60%
hind 40%
Term
Where do 95% of forelimb lameness problems occur in the leg?
Definition
distal to the carpus
Term
What are some indications of posture abnormalities?
Definition
pointing forelimb
resting hindlimb
buckling at knee or fetlock
dropped shoulder
looks like the horse is trying to "get away from front end"
Term
What things are we looking for pertaining to symmetry in a lameness exam (or when would we see asymmetry)?
Definition
overall symmetry
muscle atrophy
foot size
Term
what is a static vs dymanic conformation
Definition
static: stationary exam
- look from front & side(and back)
dynamic: walk/trot
Term
how should they feet normally land when at a trot?
Definition
should land ever so slightly lateral to medial and slightly heel to toe
Term
List some differentials for abnormal swellings of the limbs
Definition
bony swelling, soft tissue swelling, synovial effusion (joint, tendon sheath)
Term
List the components to a passive physical exam
Definition
*systemic palpation
- heat, pain/sensitivity, swelling
- digital pulses, hoof
- muscle
- limb (tendons, ligaments, joints,
tendon sheaths, bones, effusions)
- range of motion (passive flexion)
- check for foot balance
*palpate back (caution: hind limb may kick if in pain)
Term
What is a Churchill hock test?
Definition
abduction of the limb indicates tarsal pain
Term
What structures are the hoof testers used for?
Definition
sole, wall, bars, frog, heel, navicular bone
Term
Describe the Active Lameness exam and its components
Definition
*walk
*observe from front, rear, side
- symmetry of gait
- stride length
- foot arc
- foot placement
*Trot straight line (2 beat)
*Observe from front, back, and side
- symmetry of gait
- stride length
- foot arc
- foot placement
*Hard (heel/bone issues) and soft (tendon/ligament issues) surface
* Longe/circle
-lameness exacerbated (due to
overloading of inside)
- on hard (foot) vs soft (tendon/
ligament) ground
- with affected limb on the inside
or outside
*inside limbs for bony changes
*outside limbs- tendon/ligament
- Bilateral?
*Under saddle
- back soreness
- reluctant to turn/bend in one
direction
- reluctant to pick up specific
lead
- attitude
- *lameness may show at gait
transitions (esp- trot -> gallop)
Term
What are the clinical signs of forelimb lameness at a trot
Definition
head nod (down on non-lame limb)when weight bearing on sound limb

head bob (up) when loading lame limb

"down on sound"

listen to hoof landing (louder on sound leg)

watch pectoral muscles
Term
What are the clinical signs of hindlimb lameness at a trot
Definition
watch a fixed point on pelvis, tuber coxae
- pelvis drops (lame side)
- pelvis hikes (sound side)
- greatest overall excursion (top
to bottom movement)-lame side
Term
Describe each level of the AAEP lameness scale (0-5)
Definition
0: lameness not perceptible under any circumstance
1: lameness difficult to observe and is not consistently apparent regardless of curcumstance
2: lameness if difficult to observe at a walk or when trotting in a straight line, but consistently apparent under certain circumstances
3: lameness is consistently apparent at a trot under all circumstances
4: lameness is obvious at a walk
5: lameness produces minimal weight bearing in motion and/or at rest or a complete inability to move
Term
describe how to perform a joint flexion test
Definition
the veterinarian holds the horses limbs (one at a time) in a flexed position and then releases the leg. as the horse trots away, the vet watches for signs of pain, weight shifting, or irregular movement

flexing the joints in this manner may reveal problems that are not otherwise readily apparent
Term
Give some examples of specific flexion tests and what structures they stress
Definition
*fetlock/phalangeal
- 30sec, front: carpus straight,
back: minimal hock flexion
- stress: fetlock, pastern, coffin
joint, tendon sheath
*carpus
- 60sec, cannon parallel w/ ground
- stress: carpal joint, intercarpal
ligaments
*hind full limb
- 60-90sec, cannon parallel w/
ground
- stress: tarsal joints, proximal
suspensory ligament, stifle,
coxofemoral joint
Term
What is a negative vs positive grade on a flexion test
Definition
negative: no change from baseline
positive:
- mild- few steps worse than base
- moderate- increased lameness down,
may go back to baseline coming
back
- severe- obvious, severe lameness
Term
What is baseline lameness?
Definition
primary lameness
recognizable before flexion or manipulative tests
trotting on a firm surface in a straight line
Term
what is induced lameness?
Definition
after flexion tests or other manipulative tests
exacerbated primary lameness vs additional lameness
Term
what is coexistent lameness?
Definition
secondary/compensatory/complimentary
gait dependent
- trot: limbs land in diagonals
*if lame RH may look lame in LF
*if lame RF may look lame in LH

*many horses have more than one lame leg... is it lameness? or compensation?
Term
What diagnostic tests can be used to isolate the specific location and cause of lameness?
Definition
-diagnostic nerve or joint blocks
-nuclear scanning
-arthroscopy
-exam of blood, synovial fluid, tissue
-MRI
-Ultrasound
-Radiographs
-Thermography
Term
Describe the physiology of how a joint/nerve block works (including the ions involved)
Definition
Peripheral nerve membrane
- semipermeable
- K+(intracellular) Na+(extracellular)
Electrical impulse-> Na+ influx
- depolarization along nerve
Inhibition of Na+ influx
- prevents depolarization;
blocks conduction
Term
List 4 local anesthetics commonly used for nerve/joint blocks and their duration of actions
Definition
Procaine: 1-1.5 hr duration
Lidocaine: 1-3 hr duration
Mepivacaine: 2-3 hr duration
Bupivacaine: 3-6 hr duration
Term
List the types of nerve/joint blocks available.
Definition
*Regional
- Perineural
- local infiltration/ring
*Intrasynovial
- Intraarticular (joint)
- intra-bursal (bursa)
- intrathecal (tendon sheath)
Term
when should you check block efficacy & how should you check?
Definition
test skin sensation about 5-10 min after the block
Term
which type of block (nerve or joint) requires a sterile surgical prep, sterile equipment, and a new bottle of anesthetic?
Definition
Joint block
Term
What are some potential side effects of joint/nerve blocks?
Definition
Tissue damage (rare)
Soft Tissue Swelling
Term
What are some potential side effects of joint/nerve blocks?
Definition
Tissue damage (rare)
Soft Tissue Swelling
- Needle trauma, hematoma, cellulitis
(use a bandage to help reduce)
Synovitis
- nonseptic "flare"; septic
Toxicity
- Lidocaine (max dose in 500kg horse
= 300mL of 2% lidocaine)
Term
What to look for after a nerve/joint block
Definition
*improvement in lameness
*switch to another limb
*if no improvement
- more time
- keep working proximally
- intrasynovial blocks
- other diagnostics (ie-bone scan)
Term
What are some instances where we might see failure to respond to a block?
Definition
Chronic pain, habit, neuroanatomy (can change, esp. if previous nerve trauma), intermittent/subtle, mechanical lameness, correct limb? ->recheck, wrong drug?, missed the nerve?
Term
List the types of nerve blocks that are commonly used
Definition
Palmar/Plantar Digital Nerve Block
Abaxial Sesamoid Nerve Block
Low 4-point: front limb
Low 6-point: hind limb
Term
What are the landmarks for a palmar/plantar digital nerve block?
Definition
axial to the collateral cartilages
neurovascular bundle (VAN)
As low as possible
Term
Which is axial vs abaxial the vein or the nerve?
Definition
vein is abaxial
nerve is axial
Term
what is the most commonly used nerve block and why?
Definition
palmar/plantar digital nerve block

because it is most distal so we usu start with this one
Term
What structures are blocked by the palmar/plantar digital nerve block?
Definition
navicular bone, navicular bursa, DDFT, Heel, Sole and Frog, DIPJ (partially)
Term
What nerves are blocked with an abaxial sesamoid nerve block?
Definition
Palmar digital nerves and dorsal branches
Term
What are the landmarks for an abaxial sesamoid nerve block?
Definition
palmar aspect of fetlock
abaxial to sesamoid bones
axial to artery and vein
Term
What structures are blocked by an abaxial sesamoid nerve block?
Definition
foot
pastern joint
distal sesamoidean ligaments

(esentially everything below the fetlock)
Term
Which nerves are blocked with a low 4-point: front limb block?
Definition
Medial & lateral palmar nerves
Medial & lateral palmar metacarpal nerves

*2cc/each spot
Term
What are the landmarks for a low 4-point: front limb block?
Definition
at distal aspect of splint (palmar metacarpal nerve)

b/w DDFT and suspensory ligament (palmar nerve)

**careful of tendon sheath/joint**
Term
Which structures are blocked by the low 4-point: frontlimb block?
Definition
below the fetlock
Term
What nerves are blocked by the low 6-point : hind limb block?
Definition
- medial & lateral plantar nerves
- medial & lateral plantar metatarsal nerves
- dorsal metatarsal nerves (add SQ dorsal ring at level of button of splint)
Term
What structures are blocked by the low 6-point: himd limb block?
Definition
foot, pastern joint, distal sesamoid ligaments, below fetlock
Term
List the types of joint blocks that are commonly used
Definition
Coffin Joint block
Fetlock joint block
Carpal block
Tibiotarsal/Tarsocrural joint block
Distal intertarsal joint block
Tarsometatarsal joint block
Term
Where do the needle pokes go for a coffin joint block and what structures are blocked?
Definition
Pokes: Dorsal pouch (through CDE tendon -midline), Palmar pouch (lateral approach)

structures: DIPJ, Navicular bursa, +/- DDFT insertion, +/- hoof capsule
Term
Where do the needle pokes go for a fetlock joint block?
Definition
Palmar pouch (proximal, distal)
Dorsal
Collateral sesamoidean ligament
Term
What joints are blocked with a carpal block?

What type of approach to the joint is used?
Definition
Radiocarpal or antebracheocarpal

Intercarpal or middle carpal

*10cc 's total

Approach: dorsal (simpler) OR lateral (preferred; protects cartilage, dont need limb held)
Term
What approaches are used for a Tibiotarsal/tarsocrural (hock)joint block?
Definition
Dorsal approach (medial or lateral)
Plantar approach (VS tarsal sheath)
- easiest joint to block; but not
blocked often (usu. dont have
problems here)
Term
What approach is used for an intertarsal joint block?

Which tendon is a useful landmark?
Definition
Approach medially*
- tarsal bones:central; 1st/2nd; 3rd
Tendon landmark: Cunean tendon (right above where we block)
Term
What approach and landmarks are used for the tarsometatarsal joint block?
Definition
approach: caudolaterally
landmarks: above head of lateral splint
bone

*blocked often*
Term
What is the function of a joint?
Definition
energy efficient, pain free movement, transport load, support musculoskeletal system
Term
What are the components of a joint
Definition
Vascular supply, ligaments, innervation, joint capsule, synovial fluid, articular cartilage, (bone)
Term
What is a joint capsule? What is it composed of?
Definition
thick fibrous portion lined by subsynovium and synovial membrane; low cellularity

composed primarily of collagen,proteoglycan, noncollagenous proteins, water
Term
why does the synovium have villi?

What structure is adhered to the outer portion of the synovium?
Definition
- increased surface area

- joint capsule
Term
Describe the layers of the synovium.
Definition
Intima: epithelial-like layer of attached CT cells (more cellular; *1-3 layers thick)

Subintima: layer of loose irregular CT (more CT); b/w intima and joint capsule; gives pliability and elasticity
Term
Which layer of the synovium is in contact with synovial fluid and acts as a synovial/blood barrier?
Definition
Intimal layer**
Term
What cells comprise the intimal layer? and what are their functions?
Definition
*Type A synoviocytes: macrophage derived; phagocytic; digst debris w/in the joint

*Type B synoviocytes: fibroblast derived; produce hyaluronan (HA) and lubricin to keep the joint lubricated
Term
What comprises the sub-intima? how is the sub-intima important to the joint?
Definition
blood vessels, fat, nerves, fibroblasts, ECM

important for joint movement
Term
What is the function of the synovial membrane?
Definition
-low friction lining for the joint during movements (well-lubricated)
-formation of synovial fluid
-regulation of matrix turnover in synovium and cartilage (via synovial fluid)
-blood synovial barrier
-negative intro-articular pressure= joint stability
Term
What component of a joint has NO bloodsupply? why is this a problem?
Definition
Cartilage**

problem for healing; but vessels cant survive the compression of the cartilage
Term
Where do nerve fibers of the joint terminate?

Which structure in the joint is NOT innervated?
Definition
Terminate in: joint capsule, ligaments and menisci

Cartilage is NOT innervated (cant feel pain if cartilage is injured so injury will continue to happen)
Term
How do we know joint cartilage is injured if there is no innervation?
Definition
damaged cartilage-> build up of synovial fluid-> distended joint capsule-> pain
Term
Which is more damaging to a joint: joint instability or biochemical damage?
Definition
Joint instability
Term
How does the articular cartilage recieve nutrition if there is no blood supply?
Definition
Synovial fluid!
- an ultrafiltrate of plasma to which
HA and other factors are added
locally by synoviocytes (clear and
viscous, low protein, few cells)
Term
*What is the function of synovial fluid?
Definition
*nourishment of articular cartilage (and "trash can")
Role in joint stability: adhesive seal
Lubrication:
Hyaluronate**-lubrication of
synovium-on-synovium and
synovium-on-cartilage
Lubricin- binds cartilage at
surface and decreases friction
Term
Articular (hyaline) cartilage is composed of what 3 substances?
Definition
water, chondrocytes, ECM (traps water)
Term
What is the function of the chondrocytes in the articular cartilage?
Definition
**Chondrocytes:
- sparse
- synthesixes and regulates
composition of ECM
- recieves nutrients via diffusion
from synovial fluid
Term
What is the ECM composed of?
Definition
collagen*
proteoglycan*
glycoproteins
protease inhibitors, lysozyme,
fibronectin, chondronectin,
mineral, lipid
Term
What kind of collagen makes up the articular cartilage?
Definition
***cartilage
- type II
- alpha chain polypeptides
-3 alpha chains->triple helix
-helices-> fibril
Term
What is the primaryprotein core of proteoglycans foind within the articular cartilage?

what attaches to this core?
Definition
Aggrecan*
- one or more glycosaminoglycans is
attatched to the core
-chondroitin sulfate, keraten
sulfate, dermatan sulfate
Term
What is the structure/function of proteoglycans?
Definition
- attach to HA backbone via link protein to form large MW complexes

- high densty negative charges from the GAGs keeps the molecules separated and traps water

- osmotic properties provide resistance to compression
Term
Describe the physical and mechanical properties of articular cartilage
Definition
-Decrease frictional forces during joint movement
-Load distribution during weight bearing
-loads shared by various components
- *Tensile forces resisted by
osmotic pressure provided by
proteoglycans*
- Compressive forces resisted by
osmotic pressure provided by
proteoglycans**
- proteoglycans provide
viscoelastic properties and
collagen provides stiffness
by counteracting the swelling
pressure**
Term
Which is more likely assoc with a biomechanical issue vs a biochemical issue...

abnormal stresses, normal cartilage
normal stresses, abnormal cartilage
Definition
biomech: abnormal stress, normal cart.
biochem: normal stress, abnormal cart.
Term
List important inflammatory mediators
Definition
**Proteases: enzymes that break down proteins/peptides by catalyzing the hydrolysis of peptide bonds (examples: Metallo, srine, cysteine)

-cytokines, prostaglandins, O2 derived free radicals, growth factors
Term
**What are Matrix metalloproteinases (MMPs)?
Definition
- inflammatory mediators
-enzymes that degrade the ECM of articular cartilage
- released in latent form requiring activation
-categorized according to the part of the ECM that is degraded (substrate)
Term
List some examples of matrix metalloproteinases and what their action is
Definition
**Collagenase:
MMP-1,-8(sepsis),-13(key)*
- cleaves collagen triple helices**

Gelatinase: degrades denatured (unwinding)type II collagen
Stromelysin: degrades proteoglycans
Term
What are TIMPs?
Definition
tissue inhibitors of metalloproteases
- TIMP 1-4
- bind one-to-one complex inhibiting
MMP action
Term
What are aggrecanases?
Definition
**cleave aggrecan

- ADAMTS
- inhibited by TIMP-3
Term
What do MMPs and aggrecanases (ADAMTS) have in common?
Definition
they are both inflammatory mediators that break down collagen
Term
List the two important inflammatory cytokines**
Definition
Interleukin-1 and Tumor Necrosis Factor
Term
What is TNFa responsible for?
Definition
-influx of leukocytes
-secretion of chemokines
-induction chondrocyte apoptosis
-stimulates production of MMPs by chondrocytes and synoviocytes
-inhibits proteoglycan synthesis
-increased adhesion molecules
Term
List some important anti-inflammatory cytokines
Definition
IL-4,IL-10 :both decrease IL-1,TNF,MMPs

IL-1 receptor antagonist (IL-1a)
Term
What is the most commonly involved prostaglandin and what is its role?
Definition
*PGE2
- causes proteoglycan depletion from ECM**; enhances pain perception**
- production stimulated by IL-1
Term
What produces O2 derived free radicals and what is the role of free radicals?
Definition
produced by neutrophils and macrophages

**can occur as result of ischemia/ reperfusion injury**

Cleaves proteoglycan, collagen, and HA
Term
What are the consequences of imflammatory mediator actions on ECM?***
Definition
-initial biochemical damage to cartilage w/out gross abnormalities
- accelerated degradation of
collagen and proteoglycan
- inability of chondrocytes to
synth. collagen & proteoglycan
-Weakened cartilage less resistant to loading and sheer stress
-Gross cartilage lesions develop unless inciting cause corrected and inflam process controlled
-wear particles from damaged cartilage can initiate further mediator production by synovium
-spontaneous repair of cartilage lesions in incomplete or not at all
Term
Do cytokines and degradative enzymes lead to increased catabolism or anabolism of the joint?
Definition
catabolism

*result= impaired joint function
Term
What are some Developmental joint diseases
Definition
-Osteochondrosis dessicans
-Subchondral cystic lesions
-delayed ossification
Term
What is osteochondrosis?**
Definition
failure of endochondreal ossification results in thickened cartilage (failure of cartilage to turn into bone)
Term
What is Osteochondrosis dissecans (OCD)
Definition
thickened cartilage cracks and creates a cartilage/bone flap (often a result of trauma)
- trauma tore into cartilage and bone
Term
T/F: OC may result in OCD
Definition
true
Term
T/F: OCD always results from OC
Definition
false
Term
What is the signalment and clinical signs of developmental orthopedic disease?
Definition
Signalment: young animal
Clinical signs: joint effusion, mild to moderate lameness (1-2/5)
Term
What are some modes of sustaining infection in joint sepsis?
Definition
-direct penetration of joint
-extension of infection from adjacent tissues (ie. physis)
-hematogenous
Term
What is the signalment and clinical signs assoc. w/ joint sepsis
Definition
signalment: any age
Clinical signs: extreme pain (non-weight bearing), heat and swelling around joint and severe effusion of joint, depressed, off feed, febrile (not common in LA-> if an adult is febrile look for other causes)
Term
**What is the definition of osteoarthritis (OA)?
Definition
OA is a group of disorders characterized by a common end stage
- progressive deterioration of the articular cartilage
- accompanied changes in the bone and soft tissues of the joint
Term
List the **clinical signs associated with osteoarthritis
Definition
joint pain/lameness, limited range of motion, joint effusion, variable degrees of local inflammation
Term
Describe the pathologic signs and results of osteoarthritis.**
Definition
-irregularly distributed partial or full thickness cartilage loss
- loss of shiny, smooth surface;
grooves or wear lines
-Increased subchondral bone density
-Osteophyte formation
-Variable synovial inflammation
Term
What general things do you need to consider for treatment of joint disease
Definition
- use of animal
- age
- size
- disposition
- economics
- owner compliance
Term
WHat is the most important form of trx?
Definition
rest!
Term
Describe why rest is an important trx in joint disease.
Definition
reduces acute inflammation which reduces production of cytokines and MMPs

even a few days is often helpful (sometimes need a few weeks)
Term
What is/are the goal(s) of surgery for the trx of joint disease
Definition
Remove inciting cause when possible (minimize biomechanical issue)
- osteochondral fragment removal
Debridement of surface defect
Term
What are some surgical procedures that may be preformed in joint disease trx?
Definition
-internal fixation and joint reconstruction
-lavage and decontamination
-soft tissue debulking and debridement
-arthrodesis (if gross instability)
Term
What types of physical therapy may be used for joint disease trx?
Definition
- hydrotherapy
- ice
- swimming
- acupuncture/chiropractics
- "soft" laser therapy
- Galvanic or faradic electrical stimulation
-therapeutic ultrasound
-counterirritants
-radiation
-extracorporeal shock wave
-massage
-superficial heat
Term
How might nutrition be used in the trx of joint disease
Definition
-balanced diet
- supplement if necessary (be careful;
not needed w/ a balanced diet)
- weight control
- modulation of immune response and inflammation via fatty acids
Term
What drugs may be used to trx joint disease
Definition
NSAIDs
Corticosteroids
Hyaluronan
Adequan(polysulfated glycosaminoglycan)
Tetracyclines
IRAP(IL-1 receptor antagonist protein)
Neutraceuticals
Term
What is the mechanism of NSAIDs
Definition
**inhibits COX to reduce prostaglandin production
Term
***Describe corticosteroid use to trx joint disease
Definition
-intra-articular most common
(Methylprednisolone acetate;
Triamcinalone acetonide)
-Potent inhibitors of joint inflam.
-Reduce GAG synthesis
-May be chondroprotective
- sustains chondrocyte metabolic
activity and inhibits degradative
enzymes
-Detrimental effects largely overstated
Term
What is the mechanism of corticosteroids as they relate to blocking inflammation
Definition
block Phosphlipase A2 conversion of phospholids to arachodonic acid
Term
What drug will inhibit MMPs
Definition
Tetracyclines
Term
List some diseases of the distal limb
Definition
-angular limb deformities*
-physitis
-splints
-splint bone fractures
Term
List the causes of angular limb deformities
Definition
-asynchronus physeal growth
-ligamentous laxity
-tarsal/carpal cuboidal bone collapse
-carpal/tarsal bone fractures
Term
How would you Dx angular limb deformities?
Definition
determine cause of deformity
- visual assessment
- palpation for laxity
lameness
Hx-prematurity or trauma
radiography
Term
List some angular limb deformities
Definition
carpus- valgas (outward angulation)
fetlock- varus (inward angulation)
tarsus- valgas

-any combo of the above
-shound NOT be lame (if lameness is present look for other causes)
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