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Lab Med T3 - Cardiology
pa school
57
Health Care
Graduate
07/27/2010

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Term
fasting total cholesterol level indicative of hyperlipidemia:
Definition
chol >/= 240
Term
lipoprotein: delivers tiglycerides from liver to fat cells
Definition
VLDL
Term
lipoprotein: delivers cholesterol from liver to fat cells
Definition
LDL
Term
lipoproteins with the largest size and lowest densities
Definition
chilomicrons
Term
3 factors that can damage the endothelial lining of the vessles
Definition
1. HTN
2. Smoking
3. glycation
Term
cholesterol desireable range
Definition
140-199
Term
borderline high cholesterol
Definition
200-239
Term
are cholesterol levels affected by diurnal variation?
Definition
No
Term
are there significant changes in cholesterol levels after meals?
Definition
no
Term
three interfering factors of cholesterol levels
Definition
1. pregnancy
2. recent wt loss
3. intense exercise
Term
low levels of cholesterol may indicate: (5)
Definition
1. hyperthyroidism
2. malnutrition
3. severe liver dz
4. cancer
5. chronic anemia
Term
triglyceride normal range for both men and women:
Definition
men: 40-160
women: 35-135
Term
triglyceride levels greater than ___ are at risk of developing pancreatitis
Definition
>1000
Term
at what triglyceride levels do eruptive cutaneous xanthomas develop
Definition
>2000
Term
concentrations of triglycerides do not return to normal until ___ hrs after a meal
Definition
9-12hrs
Term
testing is used to monitor tx once a pt is dx w hyperliipdemia
Definition
LDL
Term
is fasting required for analysis of LDL
Definition
yes
Term
formula for LDL
Definition
total cholesterol - HDL - (Trig/5) = LDL
Term
triglyceride level has to be under ___ in order for LDL formula to work
Definition
<400
Term
normal range for LDL
Definition
100-129 = normal, high risk = >160
Term
high risk of CAD at HDL levels of:
Definition
<36
Term
what is a desireable ratio of total cholesterol:HDL
Definition
desireable <5, optimal ration 3.5
Term
single best test to predict CAD risk
Definition
HDL
Term
recommended goals of therapy are based on ___ measurements
Definition
LDL
Term
goal for therapy of a person w/o CAD and <2RF
Definition
<160
Term
goal for therapy of a pt w/o CAD and >2RF
Definition
<130LDL
Term
goal for therapy of pt w CAD
Definition
<100LDL
Term
when do you treat a pt w/o CAD and who has <2RF
Definition
treat at LDL >190
Term
when do you treat a pt w/o CAD and has >2RF
Definition
treat at LDL of >160
Term
at what level LDL do you treat a pt with CAD?
Definition
LDL >130
Term
6 RF for atherosclerosis:
Definition
1. Age (>45men/>55women)
2. FHx CAD
3. smokers
4. HTN
5. DM
6. HDL <40
Term
pt w the highest risk of CAD has the following triad:
Definition
1. >LDL
2. 3. >Trig
Term
leading cause of CHF
Definition
AMI
Term
in CHF the CBC is used to check for:
Definition
hemoconcentration
Term
serum K+ of >___ is contraindication for ACE inhibitors
Definition
>5.5
Term
useful for the dx of CHF & to grade the severity of CHF
Definition
BNP
Term
first cardiac marker to rise in blood after AMI
Definition
myoglobin
Term
myoglobin is detectable within ___hrs of chest pain
Definition
2-4hrs
Term
myoglobin levels peak at
Definition
8-12hrs
Term
myoglobin levels return to normal at
Definition
24-30hrs
Term
CPK & CKMB peaks __hrs after CP
Definition
24hrs
Term
what are the tissues that contain high levels of AST
Definition
1. heart
2. liver
3. SKmm
4. kidney
5. pancreas
Term
AST levels peak at ___hrs and return to normal in __d
Definition
peak at 24hrs and return to normal at 3-4d
Term
tissues that contain high levels of LDH
Definition
1. kidney
2. heart
3. sk mm
4. brain
5. liver
6. lungs
Term
LDH rises in ___hrs, peaks at __d and returns to normal at __d
Definition
rises within 24-48hrs, peaks at 2-3d and returns to normal at 10-14d
Term
which isoenzymes of LDH are present in cardiac tissue?
Definition
LDH1 & LDH2
Term
what is an LDH "flip"
Definition
LDH1 is higher than LDH2 indicating MI
Term
more sensative and specific marker for cardiac injury; usefull in the early detection of AMI
Definition
Troponin
Term
Troponin rises within __hrs and remains elevated for __d
Definition
rises within 3-4hrs and remains elevated for 10-14d
Term
K+ <___ causes ventricular fib
Definition
<2.5
Term
K+ >___ causes myocardial irritability
Definition
7.0
Term
_____ levels are the most useful in the differential dx of HTN
Definition
renin
Term
decreased renin levels are found in
Definition
primary aldosteronism (nfb on renin)
Term
increased levels of renin are found in [
Definition
secondary aldosteronism w malignant HTN and renovascular HTN
Term
ADO titers peak at ___wks post infections
Definition
4-6wks
Term
useful for monitoring a rheumatic fever therapy
Definition
CRP
Term
along with cholesterol:HDL, is used to predict healthy pts risk of CVD
Definition
Cardio CRP
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