“schizogony = merogeny” in malaria life cycle that produce Schizont that contain many merozoites

Schizogony occurs in hepatocytes in exoerythrocytic cycle in liver, and in red blood cells in erythrocytic cycle

stage that invades red blood cell in malaria

-contain ligands that attach to receptors to parasite can invade RBC

-unique surface coats

tissue liver cell

Example: liver cells invaded by sporozoite after host inoculated by mosquito, location of exoerythrocytic stage

rhoptries release l-histidine acid to create parasitophorous vacuole for merozoite to enter RBC

Example: malaria merozoite bind to RBC via ligands then rhoptries release L-histidine to create vacuole for parasite to enter

ligand is protein on merozoite that binds to glycophorin A receptor on red blood cell

Example: malaria merozoite binding to red blood cell

immature red blood cells

Example: young red blood cells invaded by malaria merozoite

– inside liver, malaria life cycle stages inside liver

Example: schizogeny (merogeny) of malaria in liver hepatocytes produce schizont

outside liver, malaria life cycle stages outside liver

example: merozoites from schizont infect RBC and start schizogeny (merogeny) to produce more merozoites

mobile zygote

Example: malaria zygote that penetrates gut wall to enter haemocoel 

body cavity of mosquito

Example: ookinete penetrates gut wall and rests in haemocoel body cavity to asexually replicate sporozoites

receptor on red blood cells that binds to ligand on P.vivax

-       Duffy+ = susceptible to P.vivax bc RBC contain receptor for ligand binding

-       Duffy- = not susceptible to P.vivax bc RBC lack receptor so that ligand of vivax can not bind and vivax cant invade RBC

receptor on red blood cell that binds with ligand on merozoite

Example: glycophorin A on RBC binds with ligand of merozoite during malaria invasion of red blood cells

bumps on RBC caused by parasite removing spectrin protein from membrane that causes fluidity

Example: bumps on RBC cells from invasion of malaria P.falciparum 

Hemozoin 

dark pigment caused by ingestion of hemoglobin (waste product)

Example: liver/spleen get dark pigment when parasite ingestion of hemoglobin