Term
| Carney complex? Farm Animal? |
|
Definition
LAMB
L - lentigines
AM - atrial myxoma
B - blue nevi |
|
|
Term
| What do atrial myxoma cells stain for? |
|
Definition
| CD34, CD31, Variable S-100, calretinin in 75-100% of cases |
|
|
Term
| Cardiac myxomas - Location? Exception? |
|
Definition
| most occur in the left atrium near the fossa ovalis, except for myxomas in familial syndromes which occur predominantly in the right atrium. |
|
|
Term
| Do myxomas in Carney complex have a sex predominance? |
|
Definition
|
|
Term
| Why can a myxoma be confused for metastatic adenocarcinoma? |
|
Definition
| Myxomas can contain heterologous elements and glands (2%) |
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|
Term
Idiopathic giant cell myocarditis
1) Associated with?
2) Young or Old?
3) Mean time from onset of symptoms to diagnosis?
4)Prognosis?
5) Characteristic histology?
6) Treatment? |
|
Definition
1) Autoimmune disorders
2) young
3) 5 months
4) Rapidly fatal
5) MNGC's without granulomas and diffuse geographic necrosis with mixed inflammatory infiltrate
6) Transplant - BUT it can recur in transplanted heart. |
|
|
Term
| Most common mutation in HCM affects what gene? |
|
Definition
| beta-myosin heavy chain gene |
|
|
Term
|
Definition
- Collections of plump macrophages with surrounding lymphocytes and plasma cells
-Acute rheumatic heart disease |
|
|
Term
| What are the four types of amyloidosis and which two types most commonly affect the heart? What are the extracellular proteins involved in those two? |
|
Definition
1) Primary ~ plasma cell dyscrasias**
a) Monoclonal light chains
2) Secondary ~ inflammatory conditions
3) Hereditary
4) Age-related*
a) systemic senile - TTR
b) localized senile - ANP |
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