Term
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Definition
HMG-CoA Reductase inhibitors
Reduce LDL levels by inc hepatic uptake of LDL/VLDL remnants
Reduce susceptibility of lipoproteins to oxidation
Given at night bc chol synth inc at night |
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Term
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Definition
| Dec chol synth => dec liver chol => inc LDL rec synth => inc chol recall to liver |
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Term
| Statin pharmacokinetics properties |
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Definition
High first pass effect
Low bioavailbility
High protein binding in plasa
Peak plasma conc 1-4 hrs
70% eliminated by liver |
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Term
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Definition
RHABDOMYOLYSIS
HEPATOTOXICITY
NEUROPATHY
GI sx, HA, rash, cramps, insomnia |
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Term
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Definition
pregnancy and nursing
hepatotoxicity |
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Term
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Definition
Inc coumadin levels
OAT2 inh (gemfibrozil) => inc statin levels |
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Term
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Definition
bind anionic bile acids in intestinal lumen
resin-bile acid complex cannot be absorbed and is excreted in stool
Lowering bile acids cx liver to convert lipids to bile acids
IC liver lipid conc dec => inc hepatic uptake of LDL
Useful only where LDL is elevated to reduce LDL 10-20%
Raises HDL only slightly
Reduces major coronary events & mortality |
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Term
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Definition
Statin w low bioavailability but effective
Taken PO w or w/o food in evening |
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Term
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Definition
statin
Taken PO w or w/o food anytime of day |
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Term
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Definition
statin
Taken w or w/o food in the evening |
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Term
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Definition
Bile acid-binding resin
Oral, taken w large amounts of fluid
Take other rxs 1 hr before or 4 hrs after, bc they might not be absorbed |
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Term
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Definition
Bile acid-binding resin
Taken w large amts of fluid
Take other rx 1 hr before or 4 hr after |
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Term
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Definition
Bile acid-binding resin
Taken PO |
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Term
| Bile acid-binding resins side effects |
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Definition
May inc TG
GI distress/constipation
Dec absorption of other rxs |
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Term
| Bile acid-binding resins contraindications |
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Definition
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Term
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Definition
blocks intestinal sbsoprtion of chil by inh of NPC1L1 transporter
Inh absorption by 55%
Reduces LDL ~18% |
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Term
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Definition
Dec VLDL synth cxs:
dec VLDL, inc HDL, dec TG
Acts via PPARa agonism and altered gene expression |
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Term
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Definition
Myalgias
Rhabdomyolysis (inc w statin)
Gallstones
Inc tranaminases
GI distress |
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Term
| Fibrate contraindications |
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Definition
| severe renal or hepatic dz |
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Term
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Definition
Inc warfarin conc
Inc clearance of cyclosporine (immunosuppressant) |
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Term
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Definition
Reduces VLDL and LDL, via inh of lypolysis in adipose tissue
Most effective agent for inc HDL
Near complete absorption, but short half life |
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Term
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Definition
flusing
itching
hyperglycemia
hyperuricemia
GI issues |
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Term
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Definition
Liver dz
Severe gout
Peptic ulcer |
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Term
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Definition
Antioxidant that inh chol oxidation
Slows atherosclerosis development |
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Term
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Definition
mild GI distrubance
prolongs QT interval |
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Term
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Definition
| First choice against familial hyperchol |
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Term
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Definition
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Term
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Definition
| safe combo for LDL lowering |
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Term
| Statin + chol abs. inh (Vytorin) |
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Definition
| safe combo for LDL lowering |
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