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medchem 2
2005 test
44
Medical
Graduate
12/02/2008

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Cards

Term
insulin actions
Definition

increase glucose uptake in muscle

decrease lipolysis in adipose tissue (lipolysis induces hyperglyemia)

decrease rate of glyoconeogenesis (glucose generation)

 increase formation if triglycerides

increase glucogen synthesis (stores new glucose from food)

Term
blockage of androgen receptor in men can cause
Definition
gynecomastia
Term
the patient undergoes a dexamethasone suppression test which causes a rapid decline in cortisol concentrations. this indicates:
Definition
a pituitary lesion causing elevated ACTH secretion
Term
symptoms of menopause:
Definition

low estradiol levels

absence of the menses

high LH and FSH levels

Term
advantage of prednisone over hydrocortisone (cortisol)
Definition
less sodium retention for the same anti-inflammatory response
Term
Letrozole (INN, trade name Femara)
Definition
oral non-steroidal aromatase inhibitor adjuvantly used for treatment of hormonally-responsive breast cancer. Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme.
Term
raloxifene and tamoxifen
Definition

(SERM) estrogen antagonist in breast

estrogen agonist in bone

Term
GNRH (gonadotropin-releasing hormone) agonist effects on testosterone
Definition
transient elevation followed by prolonged suppression
Term
Which one of the following is caused by methyltestosterone (17-alkylated androgen) but not by testosterone propionate?
Definition
jaundice
Term
Which antiandrogen treatment provides the greatest risk for osteoporosis
Definition
Aberelix (GnRH receptor antagonist)
Term
Growth hormone administration to a normal 60-year old male for several months could cause
Definition
hyperglycemia
Term
Androgenic steroids may cause
Definition

stimulation of erythropoiesis

hepatic tumors

virilization of female patients

jaundice

Term
what can cause anitfertility in men?
Definition

cyproterone acetate

estradiol

flutamide

continous administration of GnRH

castration

(pulsatile admin of GnRH will not cause

Term
estrogens can be indicated for:
Definition

failure of ovarian development

menopausal symptoms

atrophic vaginitis

prevention of osteoporosis

(estrogens can cause hypertension)

Term
An orally effective synthetic estrogen that is more resistant to metabolism than estradiol
Definition
mestranol
Term
insulin causes a ________in plasma amino acids levels. (increase, decrease, or no change)
Definition
decrease
Term
iodide deficiency causes a ________in plamsa TSH levels. (increase, decrease, or no change)
Definition
increase
Term
desmopressin (ADH)causes a ________in plasma sodium levels. (increase, decrease, or no change)
Definition
decrease (watered down more)
Term
clomiphene causes a ________in plasma GnRH levels. (increase, decrease, or no change)
Definition
increase
Term
GH causes a ________in plasma free fatty acid levels. (increase, decrease, or no change)
Definition
increase (increase in lipolysis)
Term
bisphosphonates causes a ________in plasma calcium levels. (increase, decrease, or no change)
Definition
decrease
Term
vitamin D3 actions
Definition
increases plasma phosphate concentrations
Term
site that a combination contraceptive pill works
Definition
ovulation
Term
site that RU486 works
Definition
implantation
Term
site that Medroxyprogesterone acetate works at:
Definition
sperm transport
ovulation
implantation
Term
May decrease plasma insulin concentrations
Definition
metformin
Term
Dosage requirements may be increased by weight gain
Definition
metformin tolbutamide (sulfonylurea)
Term
tolbutamide (sulfonylurea) side effects:
Definition
weight gain
Term
Alleviates symptoms of hyperthyroidism without affecting hormone synthesis or secretion
Definition
propranolol
Term
aminoglutethimide
Definition
used to treat high cortisol of Cushing's syndrome
Term
spironolactone used for
Definition
secondary hyperaldosteronism
Term
rheumatoid arthritis treatment of choice
Definition
prednisone
Term
secondary adrenal insufficiency drug of choice
Definition
cortisol
Term
Ghrelin
Definition
is also produced in the hypothalamic arcuate nucleus, where it stimulates the secretion of growth hormone from the anterior pituitary gland.[2]. Receptors for ghrelin are expressed by neurons in the arcuate nucleus and the ventromedial hypothalamus. The ghrelin receptor is a G protein-coupled receptor, formerly known as the GHS receptor (growth hormone secretagogue receptor).
Term
are capable of chelating Ca++
Definition
bisphosphonates
Term
secondary hyperparythyroidism
Definition
a vitamin D disorder kidney disease
Term
chronic T4 overdose symptoms
Definition
weight loss
Term
methimazole moa:
Definition
prevents the addition of iodine to tyrosineresidues of thyroglobulin
Term
what effect does cortisol have on gluconeogenesis?
Definition
stimulates gluconeogenesis in the liver
which is glucogen production
Term
what do glucocorticoids do to leukotriene synthesis?
Definition
decrease it because it is an immune response
Term
hypopigmentation
Definition
this is nothing, addisons is HYPERpigmentation
Term
anti-androgen theraputic uses
Definition
hirsutism and virilization in women
acne and baldness in both sexes
prostatic cancer
male contraception
Term
EDTA can be used for
Definition
hypercalcemia
also used: calcitonin, and glucocorticoids
Term
insulin allergies
Definition
usually occur at the side of administration

usually decrease with time
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