• Catalizes plasminogen -> Plasmin
• Hypersensitivity
• short t_1/2
• strep AB effective against strepokinase
  

• t-PA
• Activate plasminogen
• High affinity for plasminogen---fibrin

• Serine protease inhibitor (block plasmin)

1. NO receptor
2. activate guanylate cyclase: ↑ cGMP

• Made by heart
• Bind guanylate cyclase
• ↑ cGMP

1. Activate K channel
2. K goes out, prevents Ca channel from opening
3. ↓ Ca -> ↓ smooth muscle contraction

↑ NO (↑ CO & ↑ Stroke volume)

• Na channel
• Intermediate
• ↓ phase 0 depolarization

• Na channel
• Fast, low potency
• ↓ phase 3 repolarization

• Na channel
• slow potent
• ↓ phase 0 depolarization

• βB

• K channel
• block K eflux, ↑ repolarization

PGI₂

PGE₂

PGF_2a

PGA₂