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Definition
donates an “activated” methyl group for syntheses provides sulfur for synthesis of cysteine provides the activated amine for polyamine synthesis |
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Definition
constituent of glutathione (-Glu-Cys-Gly) precursor of taurine source of sulfate (SO42- ) for PAPS (activated sulfate |
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Definition
3’-phosphoadenosine 5’phosphosulfate Synthesis of iron-sulfur proteins Sulfation of oligosaccharides such as heparin sulfate Sulfation of hormones, including steroids, T3, T4 |
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Term
Methionine adenosyltransferase |
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Definition
catalyzes SAM production from Methionine, needs ATP, releases PPi and Pi |
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Definition
formed when a methyl group is donated to SAM |
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Definition
released from S-adenosylhomocysteine and can be remethylated to methionine, an analog of cystein with an extra CH2 in its carbon backbone |
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Definition
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Definition
methylated product of guanidinoacetate |
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Definition
the methylated product of phosphatidylethanolamine |
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Definition
methylated product of acetylserotonin |
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Term
sarcosine (N methylglycine) |
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Definition
methylated product of glycine |
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Term
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Definition
synthesis of this requires three successive methylation reactions |
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Definition
provides immediate energy in muscle, ATP can then resynthesize |
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Definition
24 hour urine concentration is a function of muscle mass, elevated plasma levels indicates impaired renal function |
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Term
arginine, glycine, and SAM |
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Definition
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Term
GAMT, AGAT, and SLC6A8 deficiency |
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Definition
the 3 cerebral creatine deficiency syndromes |
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Term
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Definition
Mental retardation and seizures Approximately 80% of individuals have a behavior disorder that can include autistic behaviors and self-mutilation Onset is between ages three months and three years. |
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Term
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Definition
oxidized dimer of homocysteine |
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Term
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Definition
used to designate a mixture of homocysteine and homocystine |
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Definition
methylation of homocysteine to form methionine requires |
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Definition
can also donate a ch3 to B12, liver and kidney, oxidation product of choline |
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Definition
intermediate in cystein synthesis pathway, fromed by condensation of homocysteine and serine, cleaved by hydrolysis |
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Definition
tripeptide synthesized by sequential addition of cysteine and then glycine to glutamate, protects from oxidation, detoxify h2o2, FA peroxides, and xenobiotis, synthesis of leukotriene C4 and contributs to amino acid absorption |
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Definition
a selenium containing enzyme which removes h2o2 and minimized oxidative damage |
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Definition
reduced GSH is regenerated from oxidized GSSG by |
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Definition
a peptidyl leudotriene which contains glutathione, formed via the lipoxygenase pathway from arachidonic acid, potent stimulant of bronchoconstriction |
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Definition
cycle that occurs in kidney and intestine, transpeptidase attaches extracellular AA to GSH to facilitate AA transfer into the cell |
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Definition
an amino sulfonic acid, sulfate instead of carboxyl, not used for protein synthesis |
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Term
oxidation, decarboxylation, oxidation |
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Definition
reactions to produce taurine from cysteine |
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Term
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Definition
although adults form both glycine and taurine conjugates for bile salts, neonates only use |
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Definition
abundant intracellularly in retina and leukocytes, brain and retinal development, osmoregulation, modulation of Ca processes, and membrane stabilization May regulate the expression of genes required for glucose-stimulated insulin secretion May enhance peripheral insulin sensitivity May decrease atherosclerosis |
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Term
oxidative stress or iron overload |
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Definition
taurine may protect against |
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Definition
have a lower store or taurine, inefficient reabsorption of taurine, low activity of cystathionase |
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