Term
|
Definition
1. transport
2. protection
3. regulation |
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Term
|
Definition
-liquid component of blood in which cells are suspended (55% total blood vol)
-contains albumin, globulins, fibrinogen, thrombin , transferrin, and other blood proteins
-prepared by centrifuging fresh tube of blood |
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Term
|
Definition
| blood plasma without fibrinogen or clotting factors |
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Term
|
Definition
~45%
volume of packed red blood cells |
|
|
Term
1, Leukocytosis
2. Leukocytopenia |
|
Definition
1. high WBC count
2. low WBC count |
|
|
Term
1. Thrombocytosis
2. Thrombocytopenia |
|
Definition
1. high platelet count
2. low platelet count |
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|
Term
|
Definition
|
|
Term
|
Definition
1. Fibrinogen reacts with thrombin to form fibrin
2. platelets adhere to fibrin to form clot |
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|
Term
| Characteristics of erythrocytes |
|
Definition
1. anucleated
2. biconcave disc containing hemoglobin
3. function in O2 transport
4. ~8 um in diameter |
|
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Term
|
Definition
1. genetic mutation that causes hemoglobin to be formed incorrectly (b-chain)
2. valine substituted for glutamic acid
3. sickle cell
4. cannot transport O2 well |
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Term
| Characteristics of Neutrophils |
|
Definition
1. most numerous leukocyte (50-70%)
2. very light staining granules
3. lobed nucleus
4. phagocytose bacteria
5. chemotaxis to site of infection
6. 9-14 um in diameter
7. in females, can see "drumstick" on nucleus-inactivated X chromosome |
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|
Term
| Characteristics of eosinophils |
|
Definition
1. 13 um in diameter
2. ~3% of leukocytes
3. large granules, acidophilic and look pink
4. inflammatory rxn against parasites and agents that provoke allergic rxn, activates histamine
5. lobed nucleus
6. produce growth factors |
|
|
Term
| Characteristics of Basophils |
|
Definition
1. ~8-14 um in diameter
2. allergic rxns, release histamine and heparin
3. represent less than 1% of leukocytes
4. granules are large, stain deep blue, can mask nucleus |
|
|
Term
| Characteristics of monocytes |
|
Definition
1. largest leukocyte ~9-18um
2. kidney shaped (U) nucleus
3. Become macrophages
4. phagocytose bacteria and viruses
5. ~5-9% of all leukocytes |
|
|
Term
| Characteristics of lymphocytes |
|
Definition
1. very large round nucleus (stains dark purple)
2. much smaller than granulocytes
3. ~6 to 12 um
4. T-lymphocytes (cellular immunity)
5. B-lymphocytes (humoral immunity, antibodies) |
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Term
| Characteristics of platelets |
|
Definition
1. cell fragment from megakaryocytes
2. important for blood clotting
3. circulate for 1 week and destroyed in spleen/liver
4. thrombocytopenia--bleeding
5. thrombocytosis--thrombosis |
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Term
|
Definition
1. found in spongy bone in space between endosteum and vascular endothelium
2. yellow marrow is not hemopoietically active
3. red marrow is
4. sinusoids are capillaries of bone marrow |
|
|
Term
| Hematopoiesis-common lineage |
|
Definition
1. hematopoietic stem cell
2. multipotenial stem cell
3. common myeloid and lymphoid precursors |
|
|
Term
1. pluripotent vs.
2. multipotent |
|
Definition
1. can develop into all cells
2. only give rise to cells w/in an organ |
|
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Term
|
Definition
1. loosely-organized grouping of cells located in central soft tissue portion of bones
2. principal site for blood cell formation
3. all blood cells except T-cells (thymus) develop on bone marrow before being released to bloodstream |
|
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Term
|
Definition
| site to obtain bone marrow in most patients |
|
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Term
|
Definition
1. proerythroblast
2. basophilic erythroblast
3. polychromatophilic erythroblast (most abundant)
4. orthchromatic normoblast
5. polychromatic erythrocyte
6. mature erythrocyte |
|
|
Term
|
Definition
1. myeloblast
2. promyelocyte
3. myelocyte
4. metamyelocte
5. band cell
6. neutrophil |
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