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The disease caused by the HIV virus
Acquired immune deficiency syndrome |
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The two viruses that cause AIDS
Human Immunodeficiency Virus
1 is prevalent in the US and 2 is prevalent in Africa |
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| The gene that makes the matrix and capsid proteins for HIV |
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| The gene that produces RTase, protease, and integrase for HIV |
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| The genes that produce the surface glycoproteins gp120, gp41 for HIV |
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Produced by the gag gene for HIV
structural proteins linking the viral envelope with the virus core |
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Made by the gag protein for HIV
Protein that makes up the capsid of the virus |
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Enzyme maded by pol for HIV
Enzyme that assists in reverse transcription |
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Produced by pol for HIV
enzyme produced by a retrovirus (including HIV) that enables its genetic material to be integrated into the DNA of the infected cell |
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Produced by pol for HIV
enzyme that conducts proteolysis, that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids together in the polypeptide chain |
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| Where HIV binds to on a TH cell |
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| Where HIV virus can bind to on TH cells as a co-receptor |
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| A CCR5 inhibitor used to prevent HIV from binding to TH cells |
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| Mutation in CCR5 renders an insensitivity to HIV (Northern European and Austrailian) |
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| Acute Retrovirus Syndrome |
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A mild infection about 1 to 6 weeks after infection of HIV
Muscle aches, enlarged lymph nodes, rash, malaise
Could be mistaken for mono
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| An indirect ELISA that detects antibodies against HIV to test for HIV |
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| A positive ELISA test for HIV is then screened by this to look for HIV proteins in the patient's serum |
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| Infections that can be fatal for AIDS patients |
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| A latent fection in blood vessel cells induced by HIV-1 to cause blood vessel proliferation (tumors) |
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Caused by an atypical fungus and is common in animals and children
Damages the alveoli
One of the secondary infections of AIDS |
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A protozoan disease
The protozoan reproduces in cats, feces gets inhaled or ingested, sporozoites hatch, encysts tissues, cat eats cysts to complete life cycle
A secondary infection of AIDS |
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A herpes virus
Most people get infected (as kids), virus persists (latent)
This infection reactivates in immunocompromised, damages cells in CNS (including retina --> blindness) and liver |
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This secondary infection is due to a weaker mycobacterial species than a normal infection
Often the terminal disease of AIDS |
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A fungal infection on the mucus membrane of the mouth
Also known as Thrush
A secondary infection of AIDS |
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One of the types of chemotherapy for AIDS patients
It is a combination of two RT inhibitors
Highly active anti-retroviral therapy |
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| A drug that inhibits reverse transcriptase in the HIV virus to prevent reverse transcription |
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| An RT inhibitor that is a nucleoside analog so it competes with other factors that try to promote reverse transcriptase |
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An RT inhibitor that is a non-nucleoside analog
It allosterically inhibits RTase (doesn't compete with other things) |
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Inhibits the processing of the poly protein
Can dramatically lower HIV titer, but the provirus is still there so the virus can begin replicating again |
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| A type of chemotherapy for AIDS patients that has two NRTIs and one NNRTI in one pill |
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| It is the prefered host for recombinant vaccines like the ones attempted for AIDS |
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