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Only the surface protein changes. The genetic material on the inside does not change |
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Live attenuated viruses Causes subclinical response |
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Small pox Yellow Fever Chickenpox (VZV) Sabin's polio virus MMR
Herpes Zoster Intranasal influenza (flumist) Rotavirus (for infants) |
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Caution with giving live attenuated viruses to... |
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Immunocompromised individuals HIV AIDS patients with CD4 <200
or individuals who are in close contact with immunocomnpromised |
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Killed viruses vaccine
Causes humoral and cell mediated response. Cell mediated not as robust as live virus |
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Influenza Rabies Salk Polio Vaccine HAV
"RIP Always"
More commonly need more boosters |
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HBV (antigen = recombinant HBsAg) HPV (types 6,11,16,18) |
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Careful with these vaccines with patients who are allergic to egg (egg proteins) |
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All DNA viruses are double stranded EXCEPT the parvoviridae |
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All RNA use single stranded RNA EXCEPT reovirus and rotavirus |
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What on earth does + or - stranded RNA means |
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+ strand can serve as both mRNA or template for RNA transcription
- strand must be transcribed to + strand before it can get transcribed |
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