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Molecular and Cellular radiation
Terms and/or Concepts
20
Health Care
Intermediate
08/28/2020

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Term
Apoptosis
Definition
A non-mitotic, or non-division, form of cell death that occurs when cells die without attempting division during the interphase portion of the cell life cycle is termed apoptosis
Term
Cell survival curve
Definition
A classic method of displaying the sensitivity of a particular type of cell to radiation
Term
Chromosome breakage
Definition
Double-strand break in the same rung of the DNA ladder-like structure
Term
Direct action
Definition
Biologic damage occurring as a result of ionization of atoms on essential molecules produced by straight interaction with the incident radiation.
Term
Free radicals
Definition
Low-LET radiation interacting with biologic tissue,causing damage to a cell primarily through an indirect action that involves the production of molecules
Term
Indirect action
Definition
Multistage process that first involves the production of free radicals that are created by the interaction of the radiation with water (H2O) molecules.
Term
Law of BergoniƩ and Tribondeau.
Definition
Radio-sensitivity function of the metabolic state of the cell receiving the exposure.
Term
Linear energy transfer (LET)
Definition
The average energy deposited per unit length of track
Term
Mutation
Definition
Loss or change of a base in the DNA chain represents a mutation
Term
Oxygen enhancement ratio (OER)
Definition
Ratio of the radiation dose required to cause a particular biologic response of cells or organisms in an oxygen-deprived environment to the radiation dose required to cause an identical response under normal oxygenated conditions.
Term
Point lesion
Definition
Type of injury to DNA
Term
Radiation weighting factor (WR)
Definition
Used to calculate the equivalent dose (EqD) to determine the ability of a dose of any kind of ionizing radiation to cause biologic damage.
Term
Relative biologic effectiveness (RBE)
Definition
Describes the relative capabilities of radiation with differing LETs to produce a particular biologic reaction.
Term
Target theory
Definition
Concept of radiation damage resulting from discrete and random events
Term
Covalent Cross-Links
Definition
Chemical unions created between atoms by the single sharing of one or more pairs of electrons
Term
Mitotic Death
Definition
Mitotic, or genetic, death occurs when a cell dies after one or more divisions
Term
Mitotic Delay
Definition
The failure of the cell to start dividing on time.
Term
Epithelial Tissue
Definition
The tissue that lines and covers body tissue
Term
Nervous Tissue
Definition
Conductive tissues that are found in the brain and spinal cord
Term
Muscle Tissue
Definition
Highly specialized tissues that contains fibers that affect movement of an organ or part of the body
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