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Molecular Biology Chapter 21
Stem Cells, Cell Asymmetry, and Cell Death
20
Biology
Graduate
12/04/2012

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Term
Daughter cells that form as a result of asymmetric cell division may differ in
Definition
size, shape and protein composition
Term
In mammalian development, which of the following is in the correct chronological order of events?
Definition
zygote, 4-cell, compacted morula, blastocyst
Term
in the mouse embryo, pluripotent stem cells are found in the
Definition
inner cell mass.
Term
Which of the following genes are expressed exclusively in cultured pluripotent embryonic stem cells?
Definition
a and c (Nanog and Oct4)
Term
Fully differentiated mouse fibroblasts can be reprogrammed or induced to form pluripotent stem cells when transfected with retroviral vectors expressing
Definition
KLF4, c- MYC and SOX2
Term
Dolly, the famous sheep, was cloned using
Definition
somatic cell nuclear transfer.
Term
In the Drosophila ovary, which of the following proteins is secreted from the cap cell and is responsible for creating and maintaining the niche for germ-line stem cells?
Definition
Hedgehog
Term
Which of the following is false regarding the stem cells located in the epithelium lining of the small intestine?
Definition
Lgr5 encodes the R-spondin protein.
Term
Which of the following is located in the cell lineage that gives rise to T cells?
Definition
pluripotent hematopoetic stem cell
Term
Floral meristems give rise to
Definition
Petals and Stamen
Term
The mating projection or Shmoo in budding yeast cells relies on having
Definition
Cdc42 recruited and localized to the region near the highest concentration of mating pheromone, formin proteins to nucleate the assembly of actin filaments, myosin V to move secretory vesicles to the plus (+) end of the microfilaments
Term
Even before the first cell division, the one-cell C. elegans zygote has an asymmetric distribution of
Definition
Par2 in the cortex of the posterior half of the cell.
Term
In C. elegans, which of the following is located in the lineage that gives rise to germ cells?
Definition
P1, P2 and P3
Term
The apical-basolateral polarity of epithelial cells depends on which one of the following?
Definition
the interaction between nectin and and JAM-A
Term
Which is the correct combination of proteins in polarized cells involved in planar-cell polarity?
Definition
Flamingo-Strabismus on one side and Dishevelled-Frizzled on the other
Term
Which of the following is a feature that defines a cell dying in response to tissue damage (necrosis)?
Definition
none of the above
Term
Which of the following genes encodes a caspase in C. elegans?
Definition
ced-3
Term
Which of the following apoptotic proteins is homologous to human Bcl-2?
Definition
CED-9
Term
Which of the following forms a dimer that gets displaced from the surface of the mitochondria by EGL-1?
Definition
CED-4
Term
Which of the following triggers apoptosis?
Definition
Fas Ligand and TNF-Beta
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