Term
| What are the two types of MAOs? |
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Definition
MAOA primarily metabolized norepinephrine, serotonin and epinephrine.
Dopamine and tyramine are metabolized by both MAOA and MAOB. |
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Term
| What are the five most common adverse effects of MAOIs? |
|
Definition
Orthostatic hypotension
Insomnia
Weight gain
Edema
Sexual dysfunction |
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Term
| How can MAOI-induced paresthesias be treated? |
|
Definition
| Pyridoxine supplementation of 50-150mg PO per day. |
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Term
| What are the two absolute CI and three relative CI to MAOI treatment? |
|
Definition
Absolute: thyrotoxicosis, pheochromocytoma
Relative: renal disease, cardiovascular disease, hyperthyroidism |
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Term
| How should a MAOI-induced hypertensive crisis be treated? |
|
Definition
| α-adrenergic antagonists (e.g. phentolamine or chlorpromazine) |
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Term
| How does MAOI overdose present? |
|
Definition
| 1-6 hour asymptomatic period followed by agitation that progresses to coma with ↑T°, ↑BP, ↑P, ↑RR, dilated pupils and hyperactive deep tendon reflexes. |
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Term
| What are the 8 absolutley CI drugs in a patient taking MAOIs? |
|
Definition
Antiasthmatics
Antihypertensives
Buspirone
Levodopa
Opioids
Sympathomimetics
SSRIs
L-tryptophan |
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