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Myocardial Histology&Physiolog
Lecture # 4(1st semester)
47
Health Care
Professional
03/12/2008

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Term
The outermost muscle layer that surrounds the heart
Definition
Epicardium
Term
Name the middle muscular layer of the heart
Definition
Myocardium
Term
Name the inner layer of the Heart
Definition
Endocardium
Term
What is the Myocardium composed of?
Definition
Unbundled contractile muscle fibers
Term
An electrical charge caused by the condition of ions across a membrane is termed
Definition
Action Potential
Term
What nervous system is responsible for stimulation of the myocardial tissue?
Definition
Sympathetic Nervous System
Term
The myocardium is composed of two proteins filaments named:
Definition
Myosin and Actin
Term
True or False
Cross-bridges stick out from actin filaments to interact with myosin filaments so the contraction will take effect
Definition
False
The Cross-Bridges stick out from myosin filaments to interact with actin during contraction
Term
The segment of a myofibril that extend from one Z line to the next is called:
Definition
Sarcomere
Term
What are the structures that connect the muscle fibers?
Definition
Intercalated Disks
Term
What are the structures found inside the Intercalated Disks?
Definition
Gap Junctions and Desmosomes
Term
Name the small channels or connections between cells that are filled with cytoplasma and facilitate the rapid spread of action potential so the cells work in unison as one
Definition
Gap Junctions
Term
Name the plasma membrane that surrounds the muscle fibers
Definition
Sarcolemma
Term
Name the small connections between the cells that act like cement and hold the cells together
Definition
Desmosomes
Term
The lines that separate one sarcomere from the next are called:
Definition
Z-Lines
Term
Name the darker area within the sarcomere that contains mostly thick filaments, but also has overlapping thin filaments
Definition
A-Band
Term
A narrow zone in the middle of the A-Band that contains thick(myosin) filaments only, is called:

Definition
H-Zone
Term
A lighter area that surrounds the Z-Lines is called
Definition
I-Band
Term
Invaginations or tunnel like infoldings of the sarcolemma that penetrate the muscle fibers are called
Definition
Transverse tubule
Term
Organelle that is the powerhouse of the cell, which is seen more in the heart muscle than in the skeletal muscle fibers
Definition
Mitochondria
Term
What does Mithocondria generate?
Definition
It generates  ATP, used to fuel fiber contraction
Term
Name the cell component that acts as a storage house for cytoplasm and Ca++, surrounding each myofibril and releasing Ca++  for myocardium contraction
Definition
Sarcoplasmic Reticulum
Term
What removes the Ca++ from the cytoplasm after contraction occurs, so that the muscles can relax?
Definition
Calcium Active Transport Pump
Term
Where are Calcium Active Transport Pumps stored?
Definition
In the Sarcoplasmic Reticulum
Term
What is the cell component that contains DNA and controls cell activities?
Definition
Nucleus
Term
Which three ions are involved in Action Potential?
Definition

              Na+             

K+

    Ca++

Term
Which of the three ions is responsible for firing the myocardium?

a)Sodium (Na+)

    b)Potassium (K+)

    c)Calcium (Ca++)

Definition
Sodium
Term
Which ion is responsible for contracting the myocardium?
Definition
Calcium
Term
Which ion is responsible for relaxing the myocardium?
Definition
Potassium (K+)
Term
Name the phase that is caused by the Na+ ions rapidly flowing into myocytes through fast-gated Na+ channels
Definition
Rapid Depolarization (Phase 1)
Term
What is the resting potential of the muscle fibers before contraction occurs?
Definition

-90 mV

 The voltage changes from -90mV to +30mV forming Rapid Depolarization(Phase 1)

Term
Name the phase in which Ca++ slowly moves into the cell through slow Ca++ channels, initiating cardiac muscle contraction
Definition
Plateau Phase (Phase 2)
Term
For how long does Depolarization (contraction) occur?
Definition
1/3 of the cardiac cycle
Term
Name the phase in which K+ flows out of the cell and the cardiac muscle begins to relax?
Definition
Relaxation Phase or Repolarization Phase (Phase 3)
Term
For how long does Repolarization (relaxation) occurs?
Definition
2/3 of the cardiac cycle
Term
Name the phase in which Na+ moves out of the cell and K+ moves in so that the membrane potential can be readied for another excitation

 

Definition
Resting Phase (Phase 4)
Term
If a cell were stimulated during this time frame, it would not be excitable. What is the name of this period and during what phase does  it occur?

Definition
It is called "Absolute Refractory Period" or "Effective Refractory Period", and it occurs from onset of Phase 1 until the middle of Phase 3

[image]

Term

What is the duration time of "Absolute Refractory Period"?

 

Definition
It lasts approximately as long as the muscle action potential, which is about 250milliseconds (0.25 sec)
Term
Name the period in which the myocardium can be excited again so another action potential can occur, and when does this period occur?
Definition
It occurs during resting time (Phase 4), and it's called "Relative Refractory Period"
Term
What is the total time of contraction and relaxation of the muscle?
Definition
300 milliseconds or 0.3 sec (Phase 1, 2, and 3, but not Phase 4, which is the resting time)
Term
The sarcomere shortens due to action of the actin filaments sliding over the myosin filaments. This will result in muscle contraction, and the theory is called:

[image]

Definition
Sliding Filament Theory
Term
What are the two proteins that are part of the thin filaments-actin?
Definition

-Tropomyosin

-Troponin

Term
What must be present and bind to the troponin to cause the movement of tropomyosin, so myosin and actin can interact together to produce contraction of the muscle?
Definition
Calcium
Term
What is required to release the myosin's head from the actin filament?
Definition
The breakdown of ATP to ADP
Term
What protein covers the active sites of actin?
Definition
Tropomyosin
Term
What cases the tropomyosin to uncover the actins' active site allowing myosin to interact with actin?
Definition
Troponin protein
Term
Name the theory which states that myosin must act with actin in order to have muscle fiber shortening
Definition
Sliding Filament Theory
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