Term
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Definition
| tumor suppressor gene that promotes apoptosis in cells with DNA damage |
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Term
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Definition
| neutralizes the effects of receptor kinases |
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Term
| Feline leukemia virus is associated with (B cell / T cell) lymphopmas |
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Definition
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Term
| Feline sarcoma virus (FeSV) is.... |
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Definition
mutant form of FeLV carrying fos (a proto-oncogene)
-virus transforms rapidly |
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Term
| Why is inflammation a risk factor for neoplasms? |
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Definition
| -tissue repair = chronically replicating cells, and lots of leukocytes present which produce free radicals that are mutagenic |
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Term
| What is the difference between mutagenic & non-mutagenic carinogens? |
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Definition
mutagen: clearly generates the precursor for carcinogenesis
non-mutagenic: increase cell proliferation in some way (e.g. inflammation, cause necrosis etc) |
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Term
| Characteristics of cancer stem cells |
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Definition
-low proliferation rate
-low uptake of drugs
-can self-renew & produce daughtere cells
-express stem cell markers |
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Term
| What role does telomerase play in cancer cell survival? |
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Definition
expression of telomerase allows the cells to add back missing bits of telomeric DNA, to maintain telomere length
(short telomere = short lifespan) |
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Term
| Most cancer mortality is due to ____ |
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Definition
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Term
| Avian leukosis virus (ALV) increaes expression of ______ which leads to bursal lymphoma |
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Definition
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