Term
| targets for treating seizures-4 |
|
Definition
block glutamate
strengthen GABA
blokc NA
bloack THALMIC Ca |
|
|
Term
if the drug targets Na channels what is it doing to them?
is this the majority or minority of drugs? |
|
Definition
prolonging the inactivaiton
majority |
|
|
Term
| what is the MOA of carbamezapine |
|
Definition
|
|
Term
| what is the MOA of pheytoin |
|
Definition
|
|
Term
| what is hte MOA of topirmate |
|
Definition
|
|
Term
| wht is the MOa of valproate |
|
Definition
|
|
Term
| what is the MOA of zonisamide |
|
Definition
|
|
Term
| what is the MOA of lamotrigine |
|
Definition
|
|
Term
| drugs targeting Ca channels are mostly used for what type of seizure? |
|
Definition
|
|
Term
| why are thalmic Ca channels targets? |
|
Definition
| bc they are involved in cortical discharge which pertains to absence seizures |
|
|
Term
| what are the two ways of increasing GABA |
|
Definition
presynatic- activate receptor (increases Cl)
postsynaptic- blokc reuptake transportes (GAT-1) |
|
|
Term
| how do the AEDs decrease glutamate? -2 |
|
Definition
block NMDA
block AMPA recepotrs |
|
|
Term
| what are the classicla AEDS-4 |
|
Definition
valproic acid
phenytoin
carbamazapine
ethosuximate |
|
|
Term
| what perrson do you not give AEDS to? |
|
Definition
|
|
Term
| what are the common side effects of classical AEDS: 5 |
|
Definition
sleepy, ataxia, dizzy
hypersensitive (skin rxn or hematotox
teratogenicity |
|
|
Term
| what is the least sedative classical AED |
|
Definition
|
|
Term
| what are hte pharmokinetic properrties of classical AEDS |
|
Definition
long half life
CYP 450
poor compliance due to multiple doses |
|
|
Term
what classical AEDS:
induce CYP 450?
which inhibit? |
|
Definition
phenoarbital, phenytoin, cabamezapine
valproic acid |
|
|
Term
| what is the generic of Dilantin |
|
Definition
|
|
Term
| wht is the MOA of phenytoin |
|
Definition
| slows Na recovery from inactivaiton |
|
|
Term
| what type of seizures do you use phenytoin for? -2 |
|
Definition
|
|
Term
| what is the prodrug of phenytoin used in emergencies as injectable? |
|
Definition
|
|
Term
| half life of phenytoin depends on? |
|
Definition
| concentration (higher dose=longer half life) |
|
|
Term
| how does drug conc. and dose of phenytoin correlate? |
|
Definition
| the increase in dose doesnt equal a saw amount of drug conc increase |
|
|
Term
|
Definition
|
|
Term
| what is the MOA of carbamezapine |
|
Definition
| slows Na recovery from inactivaiton |
|
|
Term
| what is the main drug for partial and tonic-clonic seizures |
|
Definition
|
|
Term
| which drug's chronic therapy decreases it half life? |
|
Definition
|
|
Term
which drug also has an active metabolite?
what metabolizes it? |
|
Definition
|
|
Term
what drug induces CYP2C
CY3A
and UGT? |
|
Definition
|
|
Term
| overdos eof this med increases seizures |
|
Definition
|
|
Term
| acute tox of carbamezapine effects-3 |
|
Definition
| coma, convulsion, resp depression |
|
|
Term
| chronic therapy of carbamezapine effects-3 |
|
Definition
| drowsy, ataxia, blurry vision |
|
|
Term
| what is the generic of Zarontin |
|
Definition
|
|
Term
| what is the MOA of ethosuximide |
|
Definition
| blocks T type Ca channels in thalamus |
|
|
Term
| what is the first line drug fro absence seizures |
|
Definition
|
|
Term
| what are the main ADRs of ethosuximide-2 |
|
Definition
|
|
Term
| what is the gneeric of Depakene |
|
Definition
|
|
Term
| what is the MOA of valproic acid-3 |
|
Definition
block NA
block Ca
enhances GABA |
|
|
Term
| what seizures are valproic used for? -2 |
|
Definition
| parital and general (even absence and myoclonic) |
|
|
Term
| this drug inhibits drugs degraded by 2C9 and UGT |
|
Definition
|
|
Term
ADE of valproic acid-2
-what is its minimal side effect compared to toher classicals? |
|
Definition
GI symptoms and weight gain (a lot of it)
sedation |
|
|
Term
|
Definition
|
|
Term
|
Definition
| allosteric modulator of GABA receptor |
|
|
Term
| what is drug of choice for neonatal seizures |
|
Definition
|
|
Term
| what seizures are phenoarbital used for-2 |
|
Definition
|
|
Term
| what are the benzodiazepines-4 |
|
Definition
lorazepam
diazepapm
clonazepam
clorazepate |
|
|
Term
| what benzodiazepines are used for status epilepticus?-2 |
|
Definition
|
|
Term
| what benzodiapenines are used for long term treatment of seizures?-2 |
|
Definition
|
|
Term
| what are the MOA of benzodiazepines |
|
Definition
| allosteric modulator of GABA receptor |
|
|
Term
| what is the generic of ativan |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| what is the generic of trileptal |
|
Definition
|
|
Term
what is the MOA of oxcabazepine?
this drug can be used for ppl who didnt respond to? |
|
Definition
blocks Na channels
carbamezapine |
|
|
Term
|
Definition
|
|
Term
| what drugs does oxacarbmezapine decrease the conc of?-2 |
|
Definition
levonorgestrel
ethinyl estradiol |
|
|
Term
| what is the generic of felbatol |
|
Definition
|
|
Term
| what is the MOA of felbamate? -2 |
|
Definition
| NMDA blocker and weak GABA modulator |
|
|
Term
| what drug's use is limited by aplastic anemia and hepatox? |
|
Definition
|
|
Term
| what is the generric og neurotonin? |
|
Definition
|
|
Term
|
Definition
| not well understood -promotes GABA release |
|
|
Term
| What is gabaepentin very useful for-3 |
|
Definition
| neuropathy, migraine, spasticity |
|
|
Term
| what ADE has no metabolism? |
|
Definition
|
|
Term
| what AED doenst have any interacitons with other AEDs |
|
Definition
|
|
Term
| what is the generic of lyrica? |
|
Definition
|
|
Term
| what is the MOA of pregabalin? |
|
Definition
| not well understood- decreases glutamate |
|
|
Term
| what is pregabalin useful for? -2 |
|
Definition
| neuropathic pain, anxiety disorder |
|
|
Term
|
Definition
|
|
Term
| what is the MOA of lamotrgine? |
|
Definition
| slow recoery of NA from inactivaiton |
|
|
Term
| which drug is metab by liver, but isnt interaciton with the CYPs? |
|
Definition
|
|
Term
| what is the generric of Topamax? |
|
Definition
|
|
Term
| what is the MOA of toprimate? -3 |
|
Definition
antag AMPA/klainate
blocks NA
activates K+ |
|
|
Term
| this is an ADE with topirmate if too fastly titrated? |
|
Definition
|
|
Term
| which drug is a preggo category D? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| inhibit GABA reuptake transporter (GAT 1) |
|
|
Term
|
Definition
|
|
Term
MOA of levecetricetam
wht does this mean? |
|
Definition
unknown
limited evidence of AED properties |
|
|
Term
|
Definition
|
|
Term
| what is the MOA of zonisamide |
|
Definition
| blocks Na and Ca channels |
|
|
Term
| zonisamide is approved for what seizures? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what are the effects of lacosamide besides AED? |
|
Definition
|
|
Term
| what is the MOA of lacosamide? |
|
Definition
| helps with Na inactivation |
|
|
Term
|
Definition
|
|
Term
|
Definition
| NA inactivation (voltage gated) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| irrevserible inhibtor of GABA transaminase (enzyme for degredation) |
|
|
Term
| which drug has a lot of vision loss ADEs |
|
Definition
|
|
Term
old vs new AEDS:
effectivenss?
side effects?
PK? |
|
Definition
about same
less ADEs (esp sedation)
better PK profiles |
|
|
