Term
| How long does it take heparin antibodies to clear from the system? |
|
Definition
| 180 days. Try to re-introduce heparin at this point |
|
|
Term
|
Definition
|
|
Term
| Alternative anticoagulants in case of HIT? |
|
Definition
Direct thrombin inhibitors- argatroban or bivalrudin
If CrCl > 30, consider injectable fondeparinux |
|
|
Term
| Which factor Xa inhibitor should be taken w/ meals? |
|
Definition
|
|
Term
| Which DOAC can cause gastritis because of its tartaric acid coating? |
|
Definition
|
|
Term
| Which DOAC has the lowest bleeding risk? |
|
Definition
|
|
Term
| Which DOAC is preferred in obese and underweight patients? |
|
Definition
|
|
Term
| Black box warning for anticoagulants? |
|
Definition
| Should not be given concomitantly w/ puncture procedure |
|
|
Term
| Which are termed "white clots" and why? |
|
Definition
Arterial clots- high flow requires very sticky platelets to form a clot
Atherosclerotic plaque rupture --> exposed vessel collagen --> platelet cascade
Tx w/ antiplatelets |
|
|
Term
| Which are termed "red clots" and why? |
|
Definition
Venous clots- blood pools --> fibrin cross-linkages --> red blood cells trapped
Tx w/ anticoagulants |
|
|
Term
| Clinically significant aggregation factors released by platelet degranulation? |
|
Definition
Adenosine diphosphate (ADP)
Thromboxane A2 |
|
|
Term
| Which antiplatelet agent is most associated w/ dyspnea? |
|
Definition
|
|
Term
| Antiplatelet agents in order of risk of bleeding? |
|
Definition
| Fibrinolytics >> GpIIb/IIIa inhibitors >> P2Y12 inhibitors |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Kcentra, phytonadione (vit K) |
|
|
Term
| Antidote for factor Xa inhibitors? |
|
Definition
|
|
Term
| Which anticoag drug can trigger a porcine hypersensitivity rxn? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Which antiplatelet med is derived from rattlesnake venom? |
|
Definition
Eptifibatide- gpIIa/IIIb receptor antagonist
Reversible peptide-derived small-molecular inhibitor |
|
|
Term
| Which antiplatelet drug class is derived from recombinant bacterial DNA? |
|
Definition
| Fibrinolytics (drugs ending in -plase) |
|
|
Term
| Which antiplatelet drug class is contraindicated in any patient w/ prior intracranial bleeding or stroke? |
|
Definition
|
|
Term
| Which antiplatelet drug requires genetic testing for CYP2C19 resistance? |
|
Definition
|
|
