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Neurobio
Development of the nervous system and neural tube defects
26
Medical
Post-Graduate
10/08/2008

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Cards

Term
At beginning of 3rd week teh developing embry exists as two layers ________
Definition
Epiblast and hypoblast
Term

Gastrulation begins_____

Definition
Formation of the primitive streak that appears on the surface of the epiblast
Term
Invagination
Definition

The process whereby cells of the epiblast migrate toward the primitive streak, detach from teh epiblast and slip beneath it

Term
Invaginating cells of the epiblast create
Definition
Endoderm and mesoderm
Term
Non-invaginating cells (remaining cells of epiblast) become
Definition
Ectoderm
Term
notochord
Definition

Endoderm cells in the midline of the embryo proliferate and detach from teh endoderm to form a solid cord of cells - notochord 

 

basis for axial skeleton

Term
What is the initial event in the process of neurulation
Definition
notochord induction of overlying ectoderm to thicken and form neural plate. Cells of neural plate make up neuroectoderm whose induction represents the inital process of neurulation
Term
Neurulation
Definition
Process by which a portion of the embryonic ectoderm folds up to form a neural tube
Term
Neural plate formation is induced by________
Definition
primitive node
Term

Neuroectoderm

Definition
ectodermal cells that differentiate into  a thick plate of pseudostratified, columnar neuroepthelial cells as a result of neural induction.
Term
Neural plate folds to form the neural tube at the ___ week for development
Definition
Fourth
Term
Neural folds consist of
Definition
neuroepithelium and adjacent surface ectoderm
Term
neural groove
Definition
groove surrounded by the neural plates
Term
neural tube
Definition
the neural tube deepsn and the neural folds approach each other and begin to fuse.
Term
Neural tube formation begins on day......
Definition
22 in teh regions of the future occipital and cervial spinal cord and proceeds rostrally and caudally
Term
Anterior Cranial Neuropore
Definition
Cranial opening => closes about day 24-25
Term
Posterior (caudal) Neuropore
Definition
caudal opening closes about day 26-27
Term
As the neural tube closes, cellular rearrangement results in the formation
Definition

Roof Plate of the Neural tube

Surface ectoderm

Term
Secondary Neurulation
Definition

The process by which the neural tube in the tail bud is formed. This becomes the sacral adn coccygeal portiosn of hte spinal cord. It involves the condensatiosn of tail bud cells into  medullary cord.

The medullary cord undergoes cavitation to form a lumen which quickly merges with the neural canal of the more cranial neural tube .

Process completed at 8 weeks of development

Term

Spinal Cord

Definition
closed tubular structure with a narrow caudal portion- prdt of closure of neuropores and complete of neurulation.
Term

Brain Vesicles

Definition
the broader cephalic portion of the closed neural tube characterized by a number of dialations
Term
Nerual Crest
Definition
groups of cells from teh top of each neural fold that dissasociate and form a variety of cell types including the ganglia of spinal nerves, postganglionic autonomic neruons and Schwann cells fo the PNS.
Term
Neural Tube defects (NTD)
Definition
when neurulation fails to occur normally.
Term
NTDs arise at weeks ______ of gestation
Definition

3 to 4

Term
craniorachischisis
Definition
dysraphishm - entire lenght of the nural tube opens onto the surface of the head and back.
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